Psychedelics as prophylactic neuroprotectants.
Science (New York, N.Y.) September 3, 2026 Maria Maiarù
A compound found in certain mushrooms prevents nerve damage during chemotherapy.
Maria Maiarù
4 papers in the library · 15 citations · publishing 2024-2026
Papers
Psilocybin ameliorates neuropathic pain-like behaviour in mice and facilitates gabapentin-mediated analgesia.
Communications Biology April 24, 2026 Tatum Askey, Daniel Allen-Ross, Daniil Luzyanin et al.
Chronic pain states remain challenging to control with current drug therapies. Here, we demonstrate that a single dose of psilocybin produces a sustained anti-nociceptive effect in chronic neuropathic pain models in male and female mice, mediated primarily by 5-HT2A receptors. Critically, psilocybin significantly potentiates the analgesic efficacy of gabapentin, a standard-of-care treatment,...
Psilocybin as a novel treatment for chronic pain
British Journal of Pharmacology November 29, 2024 Tate Askey, Reena Lasrado, Maria Maiarù et al. 13 citations
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain. This review primarily explores the utility of preclinical animal models in investigating the potential of psilocybin as an...
Psilocybin ameliorates neuropathic pain-like behaviour in mice and facilitates the gabapentin-mediated analgesia
Research Square September 19, 2024 Maria Maiarù, Tatum Askey, Daniel Allen-Ross et al. 2 citations
Abstract Chronic pain states are challenging to control with current drug therapies. Here, we demonstrate that a single dose of psilocybin can produce a sustained anti-nociceptive effect in a mouse model of chronic neuropathic pain. Beyond this, the single dose of psilocybin caused a dramatic increase in the anti-nociceptive potential of gabapentin, a widely used treatment for neuropathic pain,...