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Research Square

ISSN 2693-5015

183 papers in the library · 84 citations · publishing 2020-2026

Papers

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A Dynamical Systems Framework for Mapping Consciousness Models to Neuroelectromagnetic Field Dynamics

Research Square July 10, 2026

Abstract Contemporary consciousness science lacks a shared mathematical language for comparing theories that propose different relationships among biophysical processes, neuroelectric field dynamics, cognition, and subjective experience. Motivated by the problem of how experience relates to physical processes, we introduce a multidimensional framework in which conscious states are represented...

DOI: 10.21203/rs.3.rs-10120829/v1 (opens in new tab)

Esketamine for treatment-resistant depression: Comparing two maintenance schedules in an observational real-world study

Research Square July 9, 2026 Samuel Westenhöfer, Yamina Ehrt, Barbora Provaznikova et al.

Abstract Background : Treatment-resistant depression (TRD) is associated with substantial clinical and socioeconomic burden. Intranasal esketamine has shown efficacy for TRD in clinical trials and real-world studies. However, evidence on optimal maintenance scheduling is limited. We therefore investigated whether two maintenance schedules differing in their inter-dose intervals were associated...

DOI: 10.21203/rs.3.rs-10250654/v1 (opens in new tab)

Ketamine harm reduction: Collaborative development of a prevention ecosystem using data from the northwest of England

Research Square July 7, 2026 Rabya Mughal, Elaine Ryan-McNeill, Barbara Mezes et al.

Abstract Background Despite legitimate, evidence-based use in clinical settings, an increase in ketamine misuse has in recent years resulted in substantial adverse effects on young populations across the UK. Urological symptoms and psychological effects are among the most common side effects, often irreversible and taking place within months of regular ketamine use. The Northwest UK includes...

DOI: 10.21203/rs.3.rs-9826857/v1 (opens in new tab)

Sexual identity as a moderator of associations between lifetime MDMA/ecstasy or psilocybin use and mental health outcomes: An exploratory analysis of a nationally representative sample using NSDUH 2015–2019

Research Square July 2, 2026 Maya Seale

Sexual identity as a moderator of associations between lifetime MDMA/ecstasy or psilocybin use and mental health outcomes: An exploratory analysis of a nationally representative sample using NSDUH 2015–2019

DOI: 10.21203/rs.3.rs-10208910/v1 (opens in new tab)

Sex-Specific Effects of Psilocybin Versus Escitalopram on Anxiety and Anhedonia: A Bayesian Reanalysis of Antidepressant Treatment Outcomes

Research Square June 19, 2026 Aline Frick, Grace Blest‐hopley, Manesh Grin et al.

Abstract Rationale: Major depressive disorder (MDD) shows marked sex differences in prevalence, symptomatology, and treatment response. However, women remain underrepresented in many clinical trials, and sex-specific treatment outcomes are rarely examined. Objectives This study reanalyzed data from a randomized controlled trial comparing psilocybin and escitalopram for MDD to evaluate sex...

DOI: 10.21203/rs.3.rs-9880403/v1 (opens in new tab) Psilocybin Major depressive disorder Anxiety disorder Serotonergic +10

Indication-stratified mortality risk of ibogaine treatment under contemporary safety protocols: a multisite analysis of 19,071 patients and updated systematic review of fatalities

Research Square June 17, 2026 Martijn Arns, Kenneth Shinozuka, Joseph P Barsuglia

Abstract Ibogaine has shown early therapeutic promise for substance use disorders (SUD) and post-traumatic stress disorder in veterans, but concerns about treatment-associated cardiac arrhythmia and death have constrained clinical development. Whether this risk is uniform across indications or concentrated in specific populations is unknown. We conducted a retrospective multisite study of...

DOI: 10.21203/rs.3.rs-9966269/v1 (opens in new tab) Full text (opens in new tab) Opioid use disorder Detoxification alternative medicine Poison control Mortality rate +6

Burnout Symptom Outcomes During At-Home Ketamine-Assisted Therapy: A Real-World Retrospective Analysis of 395 Adults

Research Square June 16, 2026 Jack Swain, Davis Carter, Leonardo Vando et al.

Abstract Background Occupational burnout, recognized in ICD-11 as an occupational phenomenon, is a syndrome of chronic workplace stress comprising emotional exhaustion, cynicism (the analogue of the depersonalization dimension on the MBI-Human Services Survey form), and reduced professional efficacy on the Maslach Burnout Inventory-General Survey (MBI-GS). Burnout is common among US working...

DOI: 10.21203/rs.3.rs-10020276/v1 (opens in new tab)