Abstract Alcohol use disorder is a major global health problem, and current treatments often fail to produce lasting reductions in harmful drinking1,2. Psychedelic-assisted therapies may promote durable behavioural change by enhancing brain plasticity during emotionally meaningful experiences, but progress has been limited by a lack of experimental models that capture these context-dependent...
Research SquareMarch 10, 2026Giammarco di Gregorio, Sophia Basset, Harjot Manmohan et al.
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Abstract Depression and anxiety affect one in five adults, with age affecting prevalence. While clinical trials suggest classic psychedelics (e.g., psilocybin, LSD) and non-classic psychedelics (e.g., MDMA, ketamine) may alleviate these symptoms, it remains unclear how these relationships function in naturalistic settings or how they vary across the lifespan. We conducted a cross-sectional...
Research SquareMarch 8, 2026Sachin Shah, Hamilton Morrin
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Abstract Background: This case describes a substance-induced manic episode with psychotic features in which interaction with an AI (artificial intelligence) chatbot appeared to corroborate and reinforce the patient’s delusional thought content and to contradict medical advice. Excerpts from the patient’s interactions with the AI chatbot provide novel clinical insight into this phenomenon, which...
Research SquareMarch 5, 2026Jiao Liu, Wen-Jing Liu, Yue Qiu et al.
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Abstract Objectives Mindfulness-based exercise has been shown to enhance affective responses to exercise, yet the momentary psychological mechanisms underlying these effects remain poorly understood. The present study examined how mindfulness during exercise shapes affective experience by focusing on dynamic, momentary psychological processes across a four-week intervention. Methods Physically...
Research SquareMarch 5, 2026Kyoungmin Noh, Nicholas Baumgartner, Manuela Cortes Ospina et al.
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Abstract a. Objective b. To determine the relationship between facet-level trait mindfulness (TM) and inhibitory control (IC), and whether the relationship is moderated by sex and mediated by resting cortical activity. c. Methods d. 283 young adults (149 women; 18–30 years old) completed the Five Facet Mindfulness Questionnaire and a flanker task involving congruent and incongruent trials to...
Abstract The acute effects of psychedelic medicines include shifts in perception and awareness that can often include mystical or spiritual elements. Research suggests that these experiences can also extend into more persisting changes in spirituality, yet this area is underexplored. This study examined the effects of psychedelic experiences on spiritual beliefs using a survey of N = 151 people...
Abstract BACKGROUND Lumbosacral radicular pain (LRP) is a highly disabling condition frequently accompanied by pain-related fear, reduced physical activity, and difficulty engaging in daily activities. Although mindfulness-based and movement-based interventions are recommended for chronic low back pain, few programs have been specifically designed for individuals with LRP or developed using...
Abstract Objectives To compare the efficacy, acceptability, and feasibility of traditional Buddhist mindfulness (TBM) versus secular mindfulness-based cognitive therapy (MBCT) for residual depressive symptoms, and to examine whether TBM is non-inferior to MBCT in improving depressive symptoms and psychological wellbeing. Methods In this pilot randomized controlled trial, Buddhist adults with...
Abstract While prior research links psychedelic use to improved psychological outcomes, less is known about whether psychedelic exposure relates to engagement with formal mental health care when treatment is recognized as needed. Using pooled data from the National Survey on Drug Use and Health (2008–2019), this study examines whether lifetime psychedelic use is associated with missed needed...
Abstract Repeated mild traumatic brain injury (RmTBI) can produce lasting cognitive, emotional, and social deficits (e.g., persistent post-concussion symptoms; PPCS). Despite the prevalence of RmTBI in sports, military, and domestic violence settings, effective treatments to alleviate the neurological consequences of RmTBI remain limited. Psilocybin, a serotonergic psychedelic, can enhance...
Abstract IMPORTANCE Microdosing psilocybin may be a novel treatment for major depressive disorder (MDD). OBJECTIVE Assessing the antidepressant effects and safety of repeated low doses of psilocybin in participants diagnosed with MDD. DESIGN This was a Phase II, randomized, double-blind, placebo-controlled clinical trial. SETTING The trial was conducted from July 2022 to December 2024 at two...
Research SquareFebruary 23, 2026Kaylia Pham, Morgan Penberthy, Olivia Boyd et al.
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Abstract Mindfulness-Based Resilience Training (MBRT) was designed to improve LEO mental health and performance, and to enhance resilience in the context of acute and chronic stressors inherent to policing. Prior research has demonstrated preliminary efficacy of MBRT in improving a variety of outcomes, including burnout and sleep disturbance. The primary goal of this study was to conduct a...
Abstract Aim of study: The antidepressant effect of ketamine may be at least partly due to its antioxidant activity. The aim of the study was to assess whether ketamine develops a protective effect on HT22 neuronal cells under conditions of oxidative stress (OS) induced by hydrogen peroxide (H 2 O 2 ). Material and methods The experiment was performed on an immortalized mouse hippocampal HT22...
Rapid-acting antidepressants like ketamine and serotonergic psychedelics show promise for treatment-resistant depression (TRD), but the molecular mechanisms that contribute to their therapeutic effects remain unclear. Induced pluripotent stem cells (iPSCs) offer a platform to model human cortical neurons and investigate drug effects in a human-relevant system. Here, iPSCs from individuals with...
Abstract Background: Post-traumatic stress disorder (PTSD) is a common mental health condition affecting approximately 3-6% of the U.S. adult population annually, and is characterized by intrusive symptoms, avoidance, negative cognitive and mood alterations, and hyperarousal following trauma exposure. Ketamine shows promise as a treatment for PTSD in preliminary trials, though real-world...
Abstract The number of mindfulness-based interventions (MBIs) has proliferated in the last decade, as accessible evidence-based practices, to improve children’s mental health in school settings. However, some studies suggest that MBIs do not offer distinct advantages over other mental health promotion interventions. These inconsistent findings may be explained, at least in part, by the lack of...
Temporal interference (TI) electrical stimulation is a novel neuromodulation method that can target deep brain structures to enhance the impact of behavioral techniques. We tested the feasibility of TI in targeting the ventral striatum (VS) in concert with an emotion regulation practice (breath-focused mindfulness meditation). As an assay of target engagement, we used electroencephalography...
Abstract Personality-based differences play a critical role in determining individual responsiveness to psychological interventions; however, traditional personality models often fail to explain variability in mindfulness-based outcomes. Recently, the Otrovert construct, proposed by Kaminski (2025), has emerged as a novel personality orientation emphasizing adaptive self-regulation and...
Abstract To reduce maladaptive behaviors, cognitive-behavioral and mindfulness-based interventions can be engaged during wakefulness. Such strategies may also be engaged during sleep, providing a unique and powerful pathway to positive behavioral change. Here we describe an initial scientific investigation of Dream Yoga, a type of contemplative practice that includes a set of prescribed tasks...
Abstract Large language models (LLMs) are increasingly consulted by individuals for support during psychedelic experiences ("trip sitting"), yet no framework exists to evaluate whether these models can accurately simulate or safely respond to altered states of consciousness. We aimed to determine if LLMs can be induced to generate narratives resembling human psychedelic experiences and to...
Abstract Objectives Ultra-trail runners face sustained psychological demands during pre-competition preparation, yet little is known about factors associated with mental health in this population. Guided by Monitor and Acceptance Theory (MAT) as a heuristic process framework, this study examined associations between mindfulness facets, sport anxiety, and psychological outcomes in ultra-trail...
Abstract While prior research suggests that healthcare context shapes the mental health correlates of psychedelic use, it remains unclear whether education can mitigate these disparities—particularly across racial and ethnic groups. This study examines whether educational attainment moderates the association between lifetime psychedelic use, health insurance context (public vs. private), and...
Abstract Aims: The investigation of psychedelics as potential therapies has expanded dramatically in the past decade, leading to their study in a wide range of conditions. Here, we characterize all ongoing clinical trials utilizing a psychedelic intervention with the goals of identifying trends in experimental design and application and discuss how findings from individual, ongoing clinical...
Nitrous oxide (N2O) produces perceptual alterations and changes in large-scale brain network organization, yet its effects on task-specific visual processing remain unclear. Given the prominence of visual alterations during psychedelic exposure, we investigated how subanesthetic N2O modulates functional connectivity during visual stimulation. Thirteen healthy adults completed a...