Mindfulness
October 1, 2022
Aleksandra E. Isham, Adriana Del Palacio-Gonzalez, Barbara Dritschel
Abstract Objectives Maladaptive emotional processing of autobiographical memories is a key feature of depression that may persist during depressive remission. The primary objective of the present study was to assess the effects of an online mindfulness-based stress reduction (MBSR) intervention on emotion regulation upon everyday autobiographical memory retrieval in individuals with remitted...
Neuropharmacology
October 1, 2022
Kai Zhang, Yitan Yao, Kenji Hashimoto
68 citations
Depression is a well-known serious mental illness, and the onset of treatment using traditional antidepressants is frequently delayed by several weeks. Moreover, numerous patients with depression fail to respond to therapy. One major breakthrough in antidepressant therapy is that subanesthetic ketamine doses can rapidly alleviate depressive symptoms within hours of administering a single dose,...
Psychological Medicine
October 1, 2022
Ashish K Sahib, Joana R Loureiro, Megha M Vasavada et al.
36 citations
Subanesthetic ketamine infusion therapy can produce fast-acting antidepressant effects in patients with major depression. How single and repeated ketamine treatment modulates the whole-brain functional connectome to affect clinical outcomes remains uncharacterized. Data-driven whole brain functional connectivity (FC) analysis was used to identify the functional connections modified by ketamine...
Current Psychiatry Reports
October 1, 2022
Damien Prouzeau, Ismaël Conejero, Peter L Voyvodic et al.
32 citations
We aim to provide an overview of the current state of knowledge about the efficacy of psilocybin in the treatment of depression, as well as its mechanisms of action. Psilocybin has a large, rapid, and persistent clinical effect in the treatment of resistant or end-of-life depression. Tolerance is good, with mild side effects limited to a few hours after dosing. The studies conducted to date...
Cureus
October 1, 2022
Dev B Goel, Sarju Zilate
24 citations
Psilocybin is a plant alkaloid that is derived from precursors of tryptamine and is present in many different types of mushrooms. It has been utilized by indigenous peoples of Central and South America for centuries in a ceremonial setting to promote spiritual experiences. Indigenous societies have long employed psilocybin and other 5-HT 2A agonist classic psychedelics in their rites. They were...
Behavioral Sciences
September 29, 2022
Jesse R Caswell, Aishwarya N Duggirala, Paul Verhaeghen
Background: We examined how a newly proposed facet of rumination, that is, the (in)ability to let go, might relate to other aspects of rumination and to psychological outcomes. Methods: In two independent samples (n = 423 and 329, resp.) of college students, we measured a broad set of rumination and rumination-related measures, letting go, anxiety and dysphoria; in the second sample, we also...
Healthcare
September 28, 2022
Nitchamon Pongpitpitak, Nahathai Wongpakaran, Tinakon Wongpakaran et al.
Thirty percent of Thai medical students experienced depression. Two of the crucial factors related to depression involved borderline personality disorder symptoms and adverse family experiences, while positive strengths were documented to prevent depression. This study aimed to investigate the role of perseverance and meditation on depression; Methods: Two hundred and forty-three medical...
Frontiers in Psychiatry
September 28, 2022
K. Hassan, W. Struthers, Aditya Sankarabhotla et al.
25 citations
Intravenous and intranasal ketamine have been shown to be effective therapeutic options in patients suffering from treatment-resistant depression (TRD). The use of sublingual (SL), rapid dissolve ketamine tablets (RDT) offers a novel approach for delivery for mental health indications. This study assessed the effectiveness and safety of self-administration of off-label, SL, rapid dissolve...
JAMA Psychiatry
September 28, 2022
Hugo Bottemanne, Orphée Morlaàs, Anne Claret et al.
59 citations
Key Points Question What are the effects of ketamine on belief updating in patients with treatment-resistant depression (TRD)? Findings This case-control study in patients with TRD showed that belief updating became more optimistically biased as soon as 4 hours after a first ketamine infusion. This early cognitive effect of ketamine was formalized by stronger asymmetrical reinforcement learning...
International Journal of Molecular Sciences
September 28, 2022
Dominika Psiuk, Emilia Magdalena Nowak, Natalia Dycha et al.
36 citations
This publication discusses two compounds belonging to the psychoactive substances group which are studied in the context of depression treatment—psilocybin and esketamine. The former is a naturally occurring psychedelic. The latter was invented in the laboratory exactly 60 years ago. Although the substances were controversial in the past, recent studies indicate the potential of those...
Cognitive, Affective, & Behavioral Neuroscience
September 27, 2022
Peter F Hitchcock, Willoughby B. Britton, Kahini Mehta et al.
Cognitive theories of depression, and mindfulness theories of well-being, converge on the notion that self-judgment plays a critical role in mental health. However, these theories have rarely been tested via tasks and computational modeling analyses that can disentangle the information processes operative in self-judgments. We applied a drift-diffusion computational model to the...
Science Signaling
September 27, 2022
Leslie K. Ferrarelli
A stress hormone enables the antidepressant action of ketamine.
Zenodo (CERN European Organization for Nuclear Research)
September 26, 2022
Vidya N -, Laveena D’Mello
preprint
Purpose: There are several effective stress management approaches. They often involve habits that increase physical health, such as eating and exercise, but they may also include measures that improve cognitive and emotional performance. A number of healthcare and epidemiology experts have lately shown an interest in the stress-reduction method based on relaxation exercises. This article will...
Indian Journal of Behavioural Sciences
September 26, 2022
Akanksha Varshney, Shravan Kumar, Ved Prakash Gupta et al.
1 citation
In treatment-resistant unipolar and bipolar depression, there is increasing evidence to support the fast, although the short-lived antidepressant effect of ketamine, a non-competitive glutamate N-methyl-D-aspartate receptor antagonist. Ketamine has been shown to cause transient mood elevation or euphoria, dissociative symptoms and psychotomimetic effects when administered in unipolar or bipolar...
International Journal of Environmental Research and Public Health
September 24, 2022
Alessandra N Bazzano, Yaoyao Sun, Vaughne Chavez-Gray et al.
Mental health conditions in childhood and adolescence are increasing in the U.S. population and require early intervention, as highlighted by a recent Surgeon General’s Advisory on Protecting Youth Mental Health. These health issues, which have been exacerbated by the COVID-19 pandemic, impair functioning, and may lead to longer term reductions in quality of life. Young adolescents are likely...
Frontiers in Psychiatry
September 23, 2022
Sepideh Hariri, Ramana V. Vishnubhotla, Preeti U. Reed et al.
Introduction Anxiety and depression have increased dramatically 2–3-fold with the COVID-19 pandemic. There is an urgent need for safe, cost-effective, and scalable approaches to alleviate this parallel mental health pandemic. Meditation has previously been shown to reduce stress, anxiety, and depression symptoms. Furthermore, online delivery of mind-body interventions will be impactful in...
Frontiers in Psychiatry
September 21, 2022
Laurent Elkrief, Olivier Payette, Jean-Nicolas Foucault et al.
15 citations
About a third of patients suffering from major depression develop treatment-resistant depression (TRD). Although repetitive transcranial magnetic stimulation (rTMS) and intravenous ketamine have proven effective for the management of TRD, many patients remain refractory to treatment. We present the case of a patient suffering from bipolar TRD. The patient was referred to us after failure to...
Research Square
September 20, 2022
Jakub Vohryzek, Joana Cabral, Louis-David Lord et al.
10 citations
preprint
Abstract Psilocybin therapy for depression has started to show promise, yet the underlying causal mechanisms are not currently known. Here we leveraged the differential outcome in responders and non-responders to psilocybin (10mg and 25mg, 7 days apart) therapy for depression - to gain new insights into regions and networks implicated in the restoration of healthy brain dynamics. We used...
Psychology, Health & Medicine
September 19, 2022
Mardiana Mansor, Mei-Chan Chong, Lei-Chui Ping et al.
ABSTRACT This scoping review describes the research-based mindfulness intervention on anxiety, distress, and depression. The search strategy retrieved articles published in English from 2014 to 2019 and were retrieved across Scopus, Web of Science, Science Direct, CINAHL, and Google Scholar. The PRISMA-Scr checklist is a tool to evaluate the quality of the articles. The selection criteria...
Neuropharmacology
September 15, 2022
S Ross, M Agrawal, Roland R. Griffiths et al.
69 citations
Psychiatric and existential distress commonly occur in advanced cancer and other serious, life-threatening or end-of-life medical illnesses and are associated with poor medical and psychiatric outcomes. Currently available treatment modalities in this patient population, including medication and psychotherapy, are limited in effectiveness, especially regarding existential distress. The lack of...