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Depression research published in 2010

36 studies whose primary subject is depression were published in 2010, up from 19 in 2009. Newest first. Back to the depression overview

Studies

Antidepressant Monotherapy versus Sequential Pharmacotherapy and Mindfulness-Based Cognitive Therapy, or Placebo, for Relapse Prophylaxis in Recurrent Depression

Archives of General Psychiatry December 1, 2010 Z. Segal, Peter Bieling, T. Young et al.

Context Mindfulness Based Cognitive Therapy (MBCT) is a group-based psychosocial intervention designed to enhance self-management of prodromal symptoms associated with depressive relapse. Objective To compare rates of relapse in remitted depressed patients receiving MBCT against maintenance antidepressant pharmacotherapy, the current standard of care Design Patients who met remission criteria...

Phenomenology of adolescent inhalant intoxication.

Experimental and Clinical Psychopharmacology December 1, 2010 Eric L Garland, Matthew O Howard

Although volatile substance inhalation is prevalent in many contexts and presents a serious threat to public health, this pernicious form of substance misuse remains poorly understood. The question of why people seek and misuse inhalants may be addressed by examining phenomenological accounts of inhalant intoxication, yet few investigations of inhalant intoxication experiences are reported in...

Distance delivery of mindfulness-based cognitive therapy for depression: project UPLIFT.

Epilepsy & Behavior November 2010 Nancy J Thompson, Elizabeth Reisinger Walker, Natasha Obolensky et al.

This study evaluated the efficacy of a newly developed, home-based depression intervention for people with epilepsy. Based on mindfulness-based cognitive therapy (MBCT), the eight-session, weekly intervention was designed for group delivery via the Internet or telephone. Forty participants were randomly assigned to intervention or waitlist. Depressive symptoms and other outcomes were measured...

Why depression feels bad

Advances in Consciousness Research October 28, 2010 Mark Solms, Jaak Panksepp

We believe that conscious mental phenomena (such as feelings) are not epiphenomenal to the workings of the brain. Feelings evolved for good biological reasons; they make specific, concrete contributions to brain functioning. Notwithstanding all the philosophical complexities, therefore, the non-conscious/conscious interactions that are the focus of this book are, in our view, causal...

Examination of the factor structure and concurrent validity of the Langer Mindfulness/Mindlessness Scale.

Assessment October 27, 2010 Emily A. P. Haigh, Michael Moore, Todd B. Kashdan et al.

Langer's theory of mindfulness proposes that a mindful person seeks out and produces novelty, is attentive to context, and is flexible in thought and behavior. In three independent studies, the factor structure of the Langer Mindfulness/Mindlessness Scale was examined. Confirmatory factor analysis failed to replicate the four-factor model and a subsequent exploratory factor analysis revealed...

Feasibility and preliminary outcomes of a school-based mindfulness intervention for urban youth.

Journal of abnormal child psychology October 1, 2010 Tamar Mendelson, Mark Greenberg, Jacinda K Dariotis et al.

Youth in underserved, urban communities are at risk for a range of negative outcomes related to stress, including social-emotional difficulties, behavior problems, and poor academic performance. Mindfulness-based approaches may improve adjustment among chronically stressed and disadvantaged youth by enhancing self-regulatory capacities. This paper reports findings from a pilot randomized...

Mindfulness-based treatments for co-occurring depression and substance use disorders: what can we learn from the brain?

Addiction October 2010 Judson A. Brewer, Sarah Bowen, Joseph T Smith et al.

Both depression and substance use disorders represent major global public health concerns and are often co-occurring. Although there are ongoing discoveries regarding the pathophysiology and treatment of each condition, common mechanisms and effective treatments for co-occurring depression and substance abuse remain elusive. Mindfulness training has been shown recently to benefit both...

Mindfulness-based ‘third wave’ cognitive and behavioural therapies versus treatment as usual for depression

Cochrane Database of Systematic Reviews September 8, 2010 R. Churchill, T. Moore, P. Davies et al.

This is the protocol for a review and there is no abstract. The objectives are as follows: To examine the effectiveness and acceptability of all third wave CBT approaches compared with treatment as usual/waiting list/attention placebo control conditions for acute depression. To examine the effectiveness and acceptability of different third wave CBT approaches (ACT, compassionate mind training,...

Do dispositional rumination and/or mindfulness moderate the relationship between life hassles and psychological dysfunction in adolescents?

The Australian and New Zealand journal of psychiatry September 1, 2010 Anthony D G Marks, Donna J Sobanski, Donald W Hine

Objective: This study examined the moderating effects of dispositional rumination and mindfulness on the relationship between recent life hassles and adolescent mental health (operationalized as symptoms of depression, anxiety and stress). Method: Data collected from a sample of 317 Australian high school students comprised an inventory of recent life hassles, measures of dispositional...

Rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression: comparing ketamine and propofol anesthesia.

The Journal of ECT September 2010 Nagahisa Okamoto, Tetsuji Nakai, Kota Sakamoto et al.

Reports of the superiority of the antidepressant effect of ketamine during the conduct of electroconvulsive therapy (ECT) have been limited. We conducted an open-label trial of ketamine to determine whether ketamine as the anesthetic during ECT would provide a greater antidepressant effect than the antidepressant effect obtained with propofol. Between April 2006 and April 2007, 31 inpatients...

Mindfulness‐based cognitive therapy: an efficacious community‐based group intervention for depression and anxiety in a sample of cancer patients

The Medical Journal of Australia September 1, 2010 Greg Sharplin, Simeon B W Jones, Barbara Hancock et al. 48 citations

OBJECTIVE: To assess the impact of an 8-week structured mindfulness-based cognitive therapy (MBCT) program on individuals experiencing distress as a consequence of cancer. DESIGN, SETTING AND PARTICIPANTS: Prospective study of 16 participants with a history of cancer and five carers of people with cancer recruited from August 2008 to February 2009 through calls to the Cancer Council South...

Glutamatergic Modulators: The Future of Treating Mood Disorders?

Harvard Review of Psychiatry August 1, 2010 Carlos A. Zarate, Rodrigo Machado‐Vieira, Ioline D. Henter et al. 226 citations

Mood disorders such as bipolar disorder and major depressive disorder are common, chronic, and recurrent conditions affecting millions of individuals worldwide. Existing antidepressants and mood stabilizers used to treat these disorders are insufficient for many. Patients continue to have low remission rates, delayed onset of action, residual subsyndromal symptoms, and relapses. New therapeutic...

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression

Archives of General Psychiatry August 1, 2010 Nancy Diazgranados, Lobna Ibrahim, Nancy E. Brutsché et al. 969 citations

CONTEXT: Existing therapies for bipolar depression have a considerable lag of onset of action. Pharmacological strategies that produce rapid antidepressant effects-for instance, within a few hours or days-would have an enormous impact on patient care and public health. OBJECTIVE: To determine whether an N-methyl-D-aspartate-receptor antagonist produces rapid antidepressant effects in subjects...

Rapid Resolution of Suicidal Ideation After a Single Infusion of anN-Methyl-D-Aspartate Antagonist in Patients With Treatment-Resistant Major Depressive Disorder

The Journal of Clinical Psychiatry July 13, 2010 Nancy Diazgranados, Lobna Ibrahim, Nancy E. Brutsché et al. 563 citations

OBJECTIVE: Suicidal ideation is a medical emergency, especially when severe. Little research has been done on pharmacologic interventions that could address this problem. Ketamine, an N-methyl-D-asparate antagonist, has been reported to have antidepressant effects within hours. We examined the effects of a single dose of ketamine on suicidal ideation in subjects with treatment-resistant major...

Polysomnographic and subjective profiles of sleep continuity before and after mindfulness-based cognitive therapy in partially remitted depression.

Psychosomatic Medicine July 2010 Willoughby B. Britton, Patricia L. Haynes, Keith W Fridel et al.

To examine whether mindfulness meditation (MM) was associated with changes in objectively measured polysomnographic (PSG) sleep profiles and to relate changes in PSG sleep to subjectively reported changes in sleep and depression within the context of a randomized controlled trial. Previous studies have indicated that mindfulness and other forms of meditation training are associated with...