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Science Signaling

ISSN 1937-9145

2 papers in the library · 110 citations · publishing 2009-2022

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When the Endogenous Hallucinogenic Trace AmineN,N-Dimethyltryptamine Meets the Sigma-1 Receptor

Science Signaling March 10, 2009 Tsung‐ping Su, Teruo Hayashi, D. Bruce Vaupel 110 citations

N,N-dimethyltryptamine (DMT) is a hallucinogen found endogenously in human brain that is commonly recognized to target the 5-hydroxytryptamine 2A receptor or the trace amine-associated receptor to exert its psychedelic effect. DMT has been recently shown to bind sigma-1 receptors, which are ligand-regulated molecular chaperones whose function includes inhibiting various voltage-sensitive ion...

DOI: 10.1126/scisignal.261pe12 (opens in new tab) Hallucinogen Endogeny Pharmacology Receptor +1