Psilocybin Efficacy and Mechanisms of Action in Major Depressive Disorder: a Review.
Current Psychiatry Reports October 1, 2022 Damien Prouzeau, Ismaël Conejero, Peter L Voyvodic et al. 32 citations
We aim to provide an overview of the current state of knowledge about the efficacy of psilocybin in the treatment of depression, as well as its mechanisms of action. Psilocybin has a large, rapid, and persistent clinical effect in the treatment of resistant or end-of-life depression. Tolerance is good, with mild side effects limited to a few hours after dosing. The studies conducted to date...