Stress with ketamine tackles depression

Leslie K. Ferrarelli

Study at a glance

Characteristics	Preclinical study Peer reviewed
Intervention	Ketamine
Topics	Depression Esketamine Ketamine
Key points	Corticosterone enables the antidepressant action of ketamine.

A stress hormone enables the antidepressant action of ketamine.

Other preclinical and animal studies on ketamine for depression, most cited first.

Study	Year	Design
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression Rats	2020	Preclinical study
A Single Subanesthetic Dose of Ketamine Relieves Depression-like Behaviors Induced by Neuropathic Pain in Rats Rats with spared nerve injury (neuropathic pain model), sham-operated rats, and control...	2011	Animal experimental study
Comparison of (R)-ketamine and lanicemine on depression-like phenotype and abnormal composition of gut microbiota in a social defeat stress model Susceptible mice after chronic social defeat stress	2017	Preclinical animal study
Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression Susceptible mice in the social defeat stress model	2016	Animal experimental study
Ketamine and its metabolite, (2R,6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression Wistar-Kyoto (WKY) rats and Wistar control rats	2020	Preclinical study