Neuroscience and Biobehavioral Reviews
March 1, 2026
Andrew Laurin, Hugo Bottemanne, Samuel Bulteau et al.
2 citations
Current models of post-traumatic stress disorder (PTSD) predominantly focus on emotional dysregulation, avoidance behaviors, and intrusive symptoms, with limited attention to disturbances in bodily self-consciousness. These frameworks do not fully account for how trauma may disrupt the integration of interoceptive and exteroceptive signals underlying the sense of embodied self. Building on...
JAMA Psychiatry
September 28, 2022
Hugo Bottemanne, Orphée Morlaàs, Anne Claret et al.
59 citations
Key Points Question What are the effects of ketamine on belief updating in patients with treatment-resistant depression (TRD)? Findings This case-control study in patients with TRD showed that belief updating became more optimistically biased as soon as 4 hours after a first ketamine infusion. This early cognitive effect of ketamine was formalized by stronger asymmetrical reinforcement learning...
L'Encephale
August 1, 2022
Hugo Bottemanne, Y Longuet, Christophe Gauld
The question of how the mind works is at the heart of cognitive science. It aims to understand and explain the complex processes underlying perception, decision-making and learning, three fundamental areas of cognition. Bayesian Brain Theory, a computational approach derived from the principles of Predictive Processing (PP), offers a mechanistic and mathematical formulation of these cognitive...
L'Encephale
June 1, 2022
Hugo Bottemanne, A Baldacci, C Muller et al.
7 citations
Ketamine, a non-competitive NMDA receptor antagonist, is used as a fast-acting antidepressant therapy in depressive disorders. This treatment provokes dissociative effects associating derealization and depersonalization, and a synaptogenic signaling cascade promoting brain plasticity. Despite several preliminary studies suggesting the usefulness of its combination with psychotherapy,...
Frontiers in Psychiatry
2022
Christophe Gauld, Kristopher Nielsen, Manon Job et al.
13 citations
Reliance on sole reductionism, whether explanatory, methodological or ontological, is difficult to support in clinical psychiatry. Rather, psychiatry is challenged by a plurality of approaches. There exist multiple legitimate ways of understanding human functionality and disorder, i.e., different systems of representation, different tools, different methodologies and objectives. Pluralistic...
L'Encephale
December 1, 2021
Hugo Bottemanne, A Chevance, L Joly
Philosophy of Mind is currently one of the most prolific fields of research in philosophy and has witnessed a progressive hybridization with cognitive science. It focuses on fundamental questions to neuroscience and psychiatry, such as the nature of mental states and cognitive processes, or the relationships between mental states and the world. Anticipating the accumulation of experimental data...
L Encéphale
November 12, 2020
Hugo Bottemanne, Anne Claret, Philippe Fossati
10 citations
The hypothesis of monoaminergic deficiency has long dominated the conceptual framework for the development of new antidepressant strategies, but the limits of conventional antidepressant treatments targeting monoaminergic signaling have motivated the search for new antidepressant pathways. The success of ketamine in the management of depressive disorders has provoked a renewed interest in...
Hugo Bottemanne, Orphée Morlaàs, Anne Claret et al.
4 citations
preprint
Treatment resistant depression (TRD) is a tremendous health problem that has encouraged novel treatment strategies involving sub-anesthetic ketamine infusions. While ketamine induces rapid and sustained clinical improvement, its cognitive effects are less well known. Here we tested if ketamine alters the negative expectancies about the future that are insensitive to disconfirming information,...