23 studies whose primary subject is depression were published in 2012, down from 31 in 2011. Newest first. Back to the depression overview
December 1, 2012 K. Adhikari
Th is study employed pretest- posttest experimental group design to study the impact of vipassana at Nepal Vipassana center(NVC) on an xiety and depression of students taking the course for the first time. Th irty one subjects (students) were studied. Vipassana is found to be effective to reduce the severity of depressive symptoms significantly (p=0.001). Vipassana could be the option for...
Psychology Research and Behavior Management November 23, 2012 Teresa M Edenfield, Sy Atezaz Saeed
In recent years, complementary and alternative medicine (CAM) treatments have increased in popularity. This is especially true for treatments that are related to exercise and mindfulness-based interventions (MBIs) in the treatment of both mental and physical illness. MBIs, such as Mindfulness-based Cognitive Therapy (MBCT) and Mindfulness-Based Stress Reduction (MBSR), which are derived from...
The Gerontologist October 15, 2012 Robin R Whitebird, MaryJo Kreitzer, A Lauren Crain et al.
Purpose: Caring for a family member with dementia is associated with chronic stress, which can have significant deleterious effects on caregivers. The purpose of the Balance Study was to compare a mindfulness-based stress reduction (MBSR) intervention to a community caregiver education and support (CCES) intervention for family caregivers of people with dementia. Design and methods: We randomly...
Science October 4, 2012 Ronald S. Duman, George K. Aghajanian 1,613 citations
Basic and clinical studies demonstrate that depression is associated with reduced size of brain regions that regulate mood and cognition, including the prefrontal cortex and the hippocampus, and decreased neuronal synapses in these areas. Antidepressants can block or reverse these neuronal deficits, although typical antidepressants have limited efficacy and delayed response times of weeks to...
PLoS One September 24, 2012 Milan Scheidegger, Martin Walter, Mick Lehmann et al. 282 citations
Increasing preclinical and clinical evidence underscores the strong and rapid antidepressant properties of the glutamate-modulating NMDA receptor antagonist ketamine. Targeting the glutamatergic system might thus provide a novel molecular strategy for antidepressant treatment. Since glutamate is the most abundant and major excitatory neurotransmitter in the brain, pathophysiological changes in...
Behavioural and Cognitive Psychotherapy September 14, 2012 Lyn Ellett
Background: Emerging evidence suggests that mindfulness can be beneficial for people with distressing psychosis. This study examined the hypothesis that for people with persecutory delusions in the absence of voices, mindfulness training would lead to reductions in conviction, distress, preoccupation and impact of paranoid beliefs, as well as anxiety and depression. Method: Two case studies are...
Bipolar Disorders September 14, 2012 David A. Luckenbaugh, Lobna Ibrahim, Nancy E. Brutsché et al. 69 citations
Luckenbaugh DA, Ibrahim L, Brutsche N, Franco‐Chaves J, Mathews D, Marquardt CA, Cassarly C, Zarate CA Jr. Family history of alcohol dependence and antidepressant response to an N ‐methyl‐ d ‐aspartate antagonist in bipolar depression. Bipolar Disord 2012: 14: 880–887. Published 2012. This article is a U.S. Government work and is in the public domain in the USA. Objectives: Both ketamine and...
Philosophical transactions of the Royal Society of London. Series B, Biological sciences July 23, 2012 Ronald S. Duman, Nanxin Li 361 citations
Molecular and cellular studies have demonstrated opposing actions of stress and antidepressant treatment on the expression of neurotrophic factors, particularly brain-derived neurotrophic factor, in limbic structures of the brain. These changes in neurotrophic factor expression and function result in structural alterations, including regulation of neurogenesis, dendrite length and spine density...
Psychotherapy and Psychosomatics July 20, 2012 Willoughby B. Britton, Patricia L. Haynes, Keith W Fridel et al.
Background: Many antidepressant medications (ADM) are associated with disruptions in sleep continuity that can compromise medication adherence and impede successful treatment. The present study investigated whether mindfulness meditation (MM) training could improve self-reported and objectively measured polysomnographic (PSG) sleep profiles in depressed individuals who had achieved at least...
Journal of Psychiatric Practice July 1, 2012 William R. Marchand 309 citations
Mindfulness has been described as a practice of learning to focus attention on moment-bymoment experience with an attitude of curiosity, openness, and acceptance. Mindfulness practices have become increasingly popular as complementary therapeutic strategies for a variety of medical and psychiatric conditions. This paper provides an overview of three mindfulness interventions that have...
Journal of Clinical Psychopharmacology June 20, 2012 Lobna Ibrahim, Nancy Diazgranados, Libby Jolkovsky et al. 219 citations
Converging lines of evidence suggest that the glutamatergic system may play an increasingly important role in the development of novel therapeutics for major depressive disorder (MDD), particularly agents associated with rapid antidepressant effects. Diverse glutamatergic modulators targeting N-methyl-D-aspartate receptors have shown efficacy in MDD, but their associated psychotomimetic effects...
Social Cognitive and Affective Neuroscience June 19, 2012 Natalie A Paul, Steven J Stanton, Jeffrey M Greeson et al.
Mindfulness-based interventions are effective for reducing depressive symptoms. However, the psychological and neural mechanisms are unclear. This study examined which facets of trait mindfulness offer protection against negative bias and rumination, which are key risk factors for depression. Nineteen male volunteers completed a 2-day functional magnetic resonance imaging study. One day...
The International Journal of Neuropsychopharmacology June 7, 2012 Wallace C. Duncan, Simone Sarasso, Fabio Ferrarelli et al. 253 citations
The N-methyl-d-aspartate (NMDA) receptor antagonist ketamine has rapid antidepressant effects in treatment-resistant major depressive disorder (MDD). In rats, ketamine selectively increased electroencephalogram (EEG) slow wave activity (SWA) during non-rapid eye movement (REM) sleep and altered central brain-derived neurotrophic factor (BDNF) expression. Taken together, these findings suggest...
Journal of Contemporary Psychotherapy June 1, 2012 Lloyd Lalande, Matthew Bambling, Robert A. King et al.
Breathwork is an increasingly popular experiential approach to psychotherapy based on the use of a specific breathing technique, however, claims of positive mental health outcomes rely on anecdotal clinical evidence. To ascertain the likely efficacy of breathwork this review clarifies the approach and its theoretical assumptions and examines relevant empirical research relating to breathing...
Behaviour Research and Therapy May 30, 2012 Johanna Thünker, Reinhard Pietrowsky
Nightmares are a common and serious problem in psychotherapeutic practice, although they are seldom considered as independent mental disorders. There are some promising approaches to the treatment of nightmares, notably Imagery Rehearsal Therapy, a cognitive-restructuring treatment. The core of this approach is the modification of the nightmare script and repeated imagination of the new script....
The Journal of Alternative and Complementary Medicine April 23, 2012 Anand Dhruva, Christine Miaskowski, Donald Abrams et al.
Background: Many debilitating symptoms arise from cancer and its treatment that are often unrelieved by established methods. Pranayama, a series of yogic breathing techniques, may improve cancer-related symptoms and quality of life, but it has not been studied for this purpose. Objectives: A pilot study was performed to evaluate feasibility and to test the effects of pranayama on...
Behavioural and Cognitive Psychotherapy March 1, 2012 Vijaya Manicavasagar, Tania Perich, Gordon Parker
Background: An appreciation of cognitive predictors of change in treatment outcome may help to better understand differential treatment outcomes. The aim of this study was to examine how rumination and mindfulness impact on treatment outcome in two group-based interventions for non-melancholic depression: Cognitive Behaviour Therapy (CBT) and Mindfulness-Based Cognitive Therapy (MBCT). Method:...
British Journal of Clinical Pharmacology February 1, 2012 Xiaochen Zhao, Swarajya Lakshmi Vattem Venkata, Ruin Moaddel et al. 136 citations
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • (R,S)‐ketamine is a phencyclidine derivative that was initially developed as an anaesthetic agent and which is currently being studied in the treatment of pain and depression. After administration, the drug is extensively N‐demethylated to (R,S)‐norketamine. The pharmacokinetics of ketamine and norketamine have been extensively studied in volunteers...
Advances in Consciousness Research January 25, 2012 Johannes Michalak, Jan M. Burg, Thomas Heidenreich
During the past decade, Mindfulness-Based Cognitive Therapy (MBCT) aiming at relapse prevention in depression has been developed and empirically tested. All exercises taught during MBCT are based on the development of a heightened awareness of one’s body. The important role of the body is also stressed in a recently emerging interdisciplinary field of research termed ‘embodiment’. This research...
Psychology 2012 Lynn E. O’Connor, Jack W. Berry, David J. Stiver et al. 14 citations
Depression appears to be somewhat epidemic in the modern world. In prior empirical studies we found depression significantly associated with empathy-based guilt, empathic distress, and an overly active or misattributing moral system. In this study, we compared 98 Buddhists, who were primarily Tibetan meditation practitioners to 438 non-Buddhist, non-practicing community adults on a measure of...