Zenodo (CERN European Organization for Nuclear Research)
July 20, 2026
Menggang Yu
The core physical attributes of the brain—the lifelong decline of white matter microstructural integrity, the selective cognitive impairment caused by sleep deprivation, and the high resting-state energy consumption of the default mode network—are currently dispersed across independent domains of neuroimaging, sleep science, and cognitive neuroscience. This paper proposes that these phenomena...
Zenodo (CERN European Organization for Nuclear Research)
July 19, 2026
Satya P. Dubey
Here is the Abstract from your uploaded paper, ready to copy and paste into the Zenodo Description field: AbstractThis paper presents Neuroscience of Natural Cognitive Order: Brain Optimisation (The CIA Theoretical Framework), a theoretical neuroscience framework proposing that the human central nervous system possesses an evolved, energy-efficient baseline operating regime termed Natural...
The Journal of Headache and Pain
July 17, 2026
Siyuan Xie, Chenghui Pi, Kang Jin et al.
BACKGROUND: Migraine is highly heterogeneous, and patients exhibit substantial variability in their responses to preventive treatment. The dose-escalation strategy of topiramate further complicates early evaluation of therapeutic efficacy. Identifying neurobiological markers that can predict treatment response is therefore essential for individualized therapy. In this study, we constructed...
PsyArXiv Preprints
July 16, 2026
This paper proposes a theoretical framework for interpreting immersive neurogastronomic experiences as a form of ambient cognitive modulation. The framework originates in the direct, informal observation of approximately 6,000 guests conducted by the first author over more than six years of operation at Sensorium — an eleven-seat neurogastronomic restaurant with a controlled multisensory...
Zenodo (CERN European Organization for Nuclear Research)
July 14, 2026
J Milton
Hypothesis preprint assigning Default Mode Network to D-apparatus under REBUS-compatible premises, with illustrative state-space B-scores, psychedelic literature context, Hypothesis 0, and rival frameworks (CSTC, ALBUS/SEBUS). Companions Papers 10 and 18. Deposit as structural consciousness reading only: never dosing, diagnosis, or treatment.
medRxiv
July 14, 2026
Kristian Stefanov, Joel T. Parkinson, Flavia Sunzini et al.
Abstract Nociplastic pain represents a major burden across immune-mediated inflammatory diseases (IMIDs). It is hypothesised, but not yet demonstrated, that peripheral inflammation promotes nociplastic pain by bottom-up sensitisation of the central nervous system (CNS). In rheumatoid arthritis (RA), a prototypic IMID, we used ultra–high field (7T) brain resting-state functional MRI to evaluate...
Zenodo (CERN European Organization for Nuclear Research)
July 14, 2026
Narayan Rout
This article proposes and develops an original interdisciplinary thesis: the Mahamrityunjaya Mantra of the Rigveda (7.59.12) is the Indian civilisation's systematic response to the specific psychological wound created by the evolution of the prefrontal cortex. The article develops this thesis through seven dimensions: the evolutionary emergence of the PFC (bipedalism, cooking, social...
Zenodo (CERN European Organization for Nuclear Research)
July 12, 2026
Yue Lu
Abstract— This paper introduces a novel neuroinformatics framework rooted in Status-Relational Entropy (SRE) dynamics to deconstruct the multi-tier gating mechanisms of the human brain from a cybernetics and digital signal processing (DSP) perspective. We model the brain as a distributed, multi-tier stepped dynamic defense system managing massive environmental data throughput. The primary gate...
bioRxiv (Cold Spring Harbor Laboratory)
July 10, 2026
Joseph Giorgio, Thomas Morin, Hsiang-Yu Chen et al.
Throughout the preclinical phase of Alzheimer's disease (AD) β-amyloid (Aβ) accumulates preferentially within the default mode network (DMN), yet the functional and behavioural consequences of this pathological burden remain poorly understood. Using task-based fMRI combined with Aβ, tau, and dopamine PET in cognitively normal older adults, we show that Aβ burden impairs learning independent of...
medRxiv
July 10, 2026
Lada Kohoutová, Jevita Potheegadoo, Léa F Duong Phan Thanh et al.
Background: Hallucinations, ranging from minor (MH) to structured, are a common non-motor symptom in Parkinson's disease (PD). Structured hallucinations have been associated with altered functional connectivity (FC) between dorsal/ventral attention (DAN, VAN) and default mode (DMN) networks. As structured hallucinations are linked to rapid cognitive decline and MH are often viewed as their...
Research Square
July 7, 2026
Default Mode Network Connectivity and Nocebo Responses in Migraine: A Functional MRI Study
Communications Biology
July 3, 2026
Fengkai He, Xiaojun Xu, Y Y Zhu et al.
Depression involves dysregulation across distributed cortico-limbic circuits, and ketamine is notable for its rapid antidepressant effects. Although depression and ketamine treatment have been linked to altered brain network topology, how within-frequency and cross-frequency coupling are jointly reorganized at the brain-wide level remains unclear. Here, we developed a frequency-varying...
bioRxiv (Cold Spring Harbor Laboratory)
July 3, 2026
Sébastien Czajko, Jelle Zorn, Oussama Abdoun et al.
Nonduality is a foundational but conceptually elusive notion across several contemplative traditions. Nondual traditions challenge the assumption that a subject-object structure characteristic of ordinary experience is an intrinsic feature of conscious awareness. However, little remains known about the neurocognitive mechanisms associated with such experiential state. Here, we investigated how...
Preprints.org
July 2, 2026
preprint
The Default Mode Network and Emotional Processing: A Narrative Review of Lesion and Neuroimaging Studies
Linguistic Frontiers
July 1, 2026
Luigi Lobaccaro
Abstract: The Default Mode Network (DMN) is reshaping cognitive neuroscience, offering fresh insights into high-level cognitive processes and the relationship between the humanities and the natural sciences. This article explores how neuroscientific research on the DMN can inform a neurosemiotic approach. It builds on Duarte’s recent proposal (2020; 2022) to associate the activities of this...
Alzheimer's Disease - Diagnostics, Pathogenesis, and Treatment [Working Title]
July 1, 2026
Denis Larrivee
While most theories regarding Alzheimer’s disease (AD) pathogenesis adopt a “neurocentric” perspective, increasing evidence suggests that nonneuronal cells may be a primary site of pathogenesis in early stage AD. Several years prior to the appearance of amyloid plaques and neurofibrillary tangles (NFTs), functional connectivity (FC) changes can be observed in the human cingulate cortex, a...
Comprehensive Psychiatry
July 1, 2026
Nagara Takao, Naoya Oishi, Qi Dai et al.
Problematic Use of the Internet (PUI) has been associated with functional alterations in the default mode network (DMN), which contains critical hubs in the entire brain network. Previous studies have predicted that hub disruption leads to widespread network alterations; however, whether DMN functional connectivity mediates the relationship between PUI and global network topology remains...
Neuroimage
July 1, 2026
Yan Zhang, Xiarong Li, Zhenlan Jin et al.
Persistent debate surrounds whether the frontal lobe supports the emergence or reporting of consciousness, raising the hypothesis that distinct frontal subregions may support these processes. We addressed this by combining electroencephalography (EEG) with eye-tracking in Report and No-Report paradigms. Eye-movement features distinguished conscious and unconscious trials in the no-report task....