Neuroimage
July 1, 2026
Yan Zhang, Xiarong Li, Zhenlan Jin et al.
Persistent debate surrounds whether the frontal lobe supports the emergence or reporting of consciousness, raising the hypothesis that distinct frontal subregions may support these processes. We addressed this by combining electroencephalography (EEG) with eye-tracking in Report and No-Report paradigms. Eye-movement features distinguished conscious and unconscious trials in the no-report task....
Sensors (Basel, Switzerland)
July 1, 2026
Chuan-Wen Luo, Yang You, Xiao-Fan Huang et al.
As the pace of modern life continues to accelerate, the pressure participants face is growing, and mental health issues are becoming increasingly prominent. Against this backdrop, meditation, as a proven method for stress relief and relaxation, has garnered widespread attention. However, many people face challenges during meditation, such as difficulty entering a meditative state quickly or...
International Journal of Surgery
September 23, 2025
Zhi-Yu Geng, Yan Zhang, Hui Bi et al.
1 citation
Intraoperative low-dose esketamine failed to further improve the QoR-40 score after gynecologic malignancy laparotomy when used as part of a multimodal analgesic regimen. Further research is needed to explore the optimal dosage and indications of esketamine in this patient population.
Scientific Reports
November 6, 2024
Yan Zhang, Chu-Ke Wei, Ping Wang et al.
12 citations
Prenatal stress exerts long-term impact on neurodevelopment in the offspring, with consequences such as increasing the offspring's risk of depression in adolescence and early adulthood. S-ketamine can produce rapid and robust antidepressant effects, but it is not clear yet whether and how S-ketamine alleviates depression in prenatally stressed offspring. The current study incestigated the...
Psychiatry Research
2024
Wei Liu, Jing Yuan, Yun Wu et al.
19 citations
To examine the dose-response effect of mindfulness-based cognitive therapy (MBCT) for college students with major depressive disorder (MDD), a randomized control trial with MBCT and a wait-list (WL) group was performed. All participants were invited to self-administer a set of questionnaires at baseline, mid-intervention (4th week), and post-intervention (8th week) by the 9-item Patient Health...
Nature
October 18, 2023
Shuangshuang Ma, Min Chen, Yihao Jiang et al.
202 citations
The discrepancy between the short half-life of ketamine and its long-lasting effects is due to ketamine being trapped in NMDA receptors, and its release depends on neural activity in the lateral habenula. Ketamine, an N -methyl- d -aspartate receptor (NMDAR) antagonist^ 1 , has revolutionized the treatment of depression because of its potent, rapid and sustained antidepressant effects^ 2 – 4 ....
Psychiatry Research
August 1, 2023
Jin Liu, Xiaotian Zhao, Xiyu Wei et al.
Nitrous oxide (N2O) has demonstrated an antidepressant effect for treatment-resistant depression (TRD), but no studies investigated the effects of N2O on different cognition domains. This study aimed to test whether N2O would display pro-cognitive effects. We conducted a double-blinded, placebo-controlled, randomized controlled trial, 44 patients with TRD were randomized to N2O group (one-hour...
Acta Psychologica
March 17, 2023
Mingchao Dong, Yingwu Li, Yan Zhang
Youth depression is often associated with impairments in cognitive function, especially in executive function. This study examines the effect of an 8-session-long mindfulness training that can improve executive function in youth with depression. Sixty youths (age range 15-27 years) with depression were selected as participants and were randomized into a mindfulness training group (MTG) and a...
Psychiatry Research
2023
Xuexiao Shao, Danfeng Yan, Wenwen Kong et al.
Nitrous oxide has rapid antidepressant effects in patients with treatment-resistant depression (TRD), but its underlying mechanisms of therapeutic actions are not well understood. Moreover, most of the current studies lack objective biological indicators to evaluate the changes of nitrous oxide-induced brain function for TRD. Therefore, this study assessed the effect of nitrous oxide on brain...
Psychiatry Research
November 1, 2022
Danfeng Yan, Bangshan Liu, Xiyu Wei et al.
Nitrous oxide (N2O), an N-methyl-D-aspartate glutamate receptor antagonist, has demonstrated a rapid-onset antidepressant effect for treatment-resistant depression (TRD) preliminarily in the United States. This study aimed to test the efficacy and safety of N2O for TRD patients in China. In this double-blinded, placebo-controlled trial, 44 patients with TRD were randomized to receive a one-hour...
Frontiers in Pharmacology
2022
Chongguang Chen, Peng Huang, Kathryn Bland et al.
Selective kappa opioid receptor (KOR) agonists are promising antipruritic agents and analgesics. However, clinical development of KOR agonists has been limited by side effects, including psychotomimetic effects, dysphoria, and sedation, except for nalfurafine, and recently. CR845 (difelikefalin). Activation of KOR elicits G protein- and β-arrestin-mediated signaling. KOR-induced analgesic and...
The International Journal of Neuropsychopharmacology
November 1, 2011
Giacomo Salvadore, Jan Willem van der Veen, Yan Zhang et al.
105 citations
Amino-acid neurotransmitter system dysfunction plays a major role in the pathophysiology of major depressive disorder (MDD). We used proton magnetic resonance spectroscopy (¹H-MRS) to investigate whether prefrontal levels of amino-acid neurotransmitters predict antidepressant response to a single intravenous infusion of the N-methyl-D-aspartate (NMDA) antagonist ketamine in MDD patients....