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The Default Mode Network and Emotional Processing: A Narrative Review of Lesion and Neuroimaging Studies

Preprints.org July 2, 2026 preprint DOI: 10.20944/preprints202607.0140.v1 (opens in new tab)

Summary

AI-generated from the abstract

The default mode network (DMN) is a set of brain regions active during rest and self-referential thought, and its role in emotional processing is examined through a narrative review of lesion and neuroimaging studies. The review suggests that the DMN contributes to emotional regulation and the integration of emotional experiences with autobiographical memory. Lesion studies indicate that damage to DMN regions can impair emotional processing, while neuroimaging studies show altered DMN activity in mood disorders. The authors argue that the DMN's connectivity with other networks is crucial for adaptive emotional functioning.

Study at a glance

Characteristics Narrative review
Key finding The default mode network plays a key role in emotional processing, with lesion and neuroimaging evidence linking it to emotional regulation and mood disorders.

Abstract

The Default Mode Network and Emotional Processing: A Narrative Review of Lesion and Neuroimaging Studies

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