Dopamine Compensates for Amyloid-Induced Default Mode Network Dysfunction to Support Learning
bioRxiv (Cold Spring Harbor Laboratory) July 10, 2026 Joseph Giorgio, Thomas Morin, Hsiang-Yu Chen et al.
Throughout the preclinical phase of Alzheimer's disease (AD) β-amyloid (Aβ) accumulates preferentially within the default mode network (DMN), yet the functional and behavioural consequences of this pathological burden remain poorly understood. Using task-based fMRI combined with Aβ, tau, and dopamine PET in cognitively normal older adults, we show that Aβ burden impairs learning independent of...