Increasing multiculturalism and globalization have increased the discrepancies between socially-shared norms and personal values. This study examined whether the association between Cultural Estrangement (CE) and resting-state functional connectivity (FC) of the default mode network (DMN) is moderated by self-esteem (SE). In total, 170 healthy Japanese adults (20–70 years) were recruited, 70 of...
Problematic Use of the Internet (PUI) has been associated with functional alterations in the default mode network (DMN), which contains critical hubs in the entire brain network. Previous studies have predicted that hub disruption leads to widespread network alterations; however, whether DMN functional connectivity mediates the relationship between PUI and global network topology remains...
Abstract Increasing multiculturalism and globalization have increased the discrepancies between sociallyshared norms and personal values. This study investigated whether Cultural Estrangement (CE) and self-esteem (SE) interact to influence functional connectivity (FC) in the default mode network (DMN). In total, 170 healthy Japanese adults (18–70 years) were recruited, 70 of whom completed the...
IntroductionAlthough a number of neuroimaging studies on problematic internet use (PIU) have been conducted, few studies on non-problematic internet use (non-PIU) are available; therefore, the influences of non-PIU on brain function are unclear. Resting-state functional connectivity (rsFC) could be an appropriate tool to investigate subclinical samples, such as non-PIU, to capture the...
Ketamine, a rapid-acting antidepressant, has undesirable psychotomimetic effects, including a dissociative effect. There is currently no effective strategy to suppress these side effects while preserving its antidepressant effect. Here, we investigated the effects of a D2/D3 receptor antagonist and partial agonists on the psychotomimetic and antidepressant effects of ketamine in mice and...
NeuronFebruary 1, 2024Ayako Kawatake-Kuno, Haiyan Li, Hiromichi Inaba et al.
Summary Despite the rapid and sustained antidepressant effects of ketamine and its metabolites, their underlying cellular and molecular mechanisms are not fully understood. Here, we demonstrate that the sustained antidepressant-like behavioral effects of (2S,6S)-hydroxynorketamine (HNK) in repeatedly stressed animal models involve neurobiological changes in the anterior paraventricular nucleus...