Comprehensive Psychiatry
July 1, 2026
Nagara Takao, Naoya Oishi, Qi Dai et al.
Problematic Use of the Internet (PUI) has been associated with functional alterations in the default mode network (DMN), which contains critical hubs in the entire brain network. Previous studies have predicted that hub disruption leads to widespread network alterations; however, whether DMN functional connectivity mediates the relationship between PUI and global network topology remains...
Comprehensive Psychiatry
July 1, 2025
Luca Pellegrini, Naomi A Fineberg, Sorcha O'Connor et al.
17 citations
Obsessive-compulsive disorder (OCD) is a common and disabling condition. A large proportion of patients fail to respond to first-line treatment with serotonin reuptake inhibitors either selective serotonin reuptake inhibitors (SSRIs) or clomipramine. Preliminary evidence suggests psilocybin, a serotonin receptor agonist, might be efficacious. We conducted a pharmacological challenge study to...
Comprehensive Psychiatry
May 1, 2024
Chen Zhang, Xiaochen Zhang, Wenqing Li et al.
Mindfulness-based cognitive therapy (MBCT) has been documented to be effective in treating obsessive-compulsive disorder (OCD). However, the neurobiological basis of MBCT remains largely elusive, which makes it clinically challenging to predict which patients are more likely to respond poorly. Hence, identifying biomarkers for predicting treatment outcomes holds both scientific and clinical...
Comprehensive Psychiatry
August 18, 2022
Juan Francisco Rodríguez Testal, S. Fuentes-Márquez, Cristina Senín‐calderón et al.
5 citations
BACKGROUND: The concept of aberrant salience is related to the onset of psychosis. Its study is important for early identification and possible intervention in processes activating later positive symptoms. OBJECTIVES: This study validated the Spanish Aberrant Salience Inventory (ASI) for adult and clinical populations. METHODS: The sample consisted of 6178 participants, of whom 4523 were...
Comprehensive Psychiatry
March 24, 2022
Magdalena Wizła, Shane W. Kraus, Karol Lewczuk
Recently, there has been an increase in studies yielding evidence for psychedelics' anxiolytic and anti-depressive qualities. Preliminary evidence for treatment in substance addiction is also available. In our manuscript, we present a perspective on the possible effectiveness and mechanisms of action of psychedelics' introduction in the treatment of Compulsive Sexual Behavior Disorder (CSBD)...
Comprehensive Psychiatry
July 1, 2021
Josef J Bless, Kenneth Hugdahl, Bodil Kråkvik et al.
Few studies have investigated hallucinations that occur at the onset/offset of sleep (called hypnagogic/hypnopompic hallucinations; HHHs), despite the fact that their prevalence in the general population is reported to be higher than the prevalence of daytime hallucinations. We utilized data from an epidemiological study to explore the prevalence of HHHs in various modalities. We also...
Comprehensive Psychiatry
February 2, 2021
Florent Poupart, Manon Bouscail, Gésine Sturm et al.
12 citations
OBJECTIVES: Two of Europe's most influential psychopathologists at the start of the twentieth century (Eugen Bleuler and Karl Jaspers) pointed out the fact that patients rarely act according to their delusions. This study proposes an investigation of how this issue is addressed in psychopathological literature. METHODS: This article offers a critical review of psychopathological literature...
Comprehensive Psychiatry
November 1, 2016
Paulo César Ribeiro Barbosa, Rick J. Strassman, Dartiu Xavier Da Silveira et al.
104 citations
Hoasca (also called ayahuasca) is a N,N-dimethyltryptamine (DMT) - containing psychedelic brew originally used for magico-religious purposes by Amerindian populations of the Amazon Basin. Recently, Brazilian syncretic churches have helped spread the ritual use of hoasca to Western societies. The aim of this study was to evaluate substance use, and neuropsychological and psychological...
Comprehensive Psychiatry
February 1, 2016
Anna Comparelli, Valentina Corigliano, Antonella De Carolis et al.
Empirical and theoretical studies support the notion that anomalous self-experience (ASE) may constitute a phenotypic aspect of vulnerability to schizophrenia, but there are no studies examining the relationship of ASE with other clinical risk factors in a sample of ultra-high risk (UHR) subjects. The aim of the present study was to explore the relationship between ASE, prodromal symptoms,...
Comprehensive Psychiatry
April 20, 2006
Giovanni Martinotti, Sara Andreoli, Emanuela Giametta et al.
67 citations
ObjectiveA few personality traits are characteristic of pathologic gamblers (PGs), but it is not clear if and how their personality profile differs from that of non-pathologic gamblers (non-PGs).MethodsSixty-five non-clinical subjects, differentiated into non-PGs and PGs with the means of the South Oak Gambling Screen (SOGS) and Diagnostic and Statistical Manual of Mental Disorders-Fourth...