Preprints.org
September 9, 2026
Qi Cui, Zheng Meng Sun
preprint
The rapid scaling of large language models (LLMs) and sparse mixture-of-experts (MoE) architectures reframes a foundational question about intelligence: must intelligent systems rely on large-scale, serial, and explicit computation, or does natural intelligence employ a faster, lower-level response mechanism than neuronal networks and explicit cognition? We introduce the Physical Fast Network...
Preprints.org
September 3, 2026
Izak Tait, Ziqi Wang, Joshua Bensemann
preprint
This paper explores the classification of artificial consciousness through the lens of the Building Blocks Theory, an attributional functionalist framework. Previous research indicates that while current transformer-based Large Language Models (LLMs) satisfy seven of the nine functional prerequisites for phenomenal consciousness, they fundamentally lack recurrent computing and processing, as...
Preprints.org
August 31, 2026
preprint
Are There Different Routes to a Delusion? A Mechanistic Framework for Convergent Psychosis
Preprints.org
August 21, 2026
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A Recursive-Heaviside Model of Consciousness: The Survival Objective, Thought as Differentiation, the Self-Generative Dummy Source, and the Finite-Order Wall of Deception
Preprints.org
August 20, 2026
preprint
Self-Transcendence as a Therapeutic Model: Rethinking Emotional Regulation and Mental Health Care
Preprints.org
August 7, 2026
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Mindfulness Between Tradition and Innovation: From Buddhist Psychology to Evidence-Based Intervention
Preprints.org
July 29, 2026
Tonatiu Campos-García
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This essay proposes the elegant simulation as a reframing of the philosophical simulation debate. Its aim is not to provide evidence that reality is or is not a simulation, but to ask what kind of architecture would make a simulated reality plausible as a lived world. Contemporary discussions of simulation often focus on whether our world could be generated by advanced external agents. I argue...
Preprints.org
July 23, 2026
preprint
The Origin and Nature of Consciousness: From the Genetic Code to Subjective Experience
Preprints.org
July 20, 2026
Michael Timothy Bennett
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Is an ant colony conscious? What about a culture, an AI, or a planet? A conscious moment feels unified in time and space, yet signals take time to travel. Many theories bind an experience's parts within a window of duration θ, but leave other questions about time and space unanswered. Here I give a mathematical tool for answering some of those questions, narrowing down what is conscious under...
Preprints.org
July 3, 2026
Okwuchukwu Adachukwu Heavenah, Ugochukwu Samuel Aguwa, Ukoha Ukoha
preprint
Biochemical and Histopathological Evaluations of the Kidney and Liver in Ketamine-Induced Schizophrenic Model in Wistar Rats
Preprints.org
July 2, 2026
preprint
The Hard Problem of consciousness remains unsolved, as most current models lack explicit causal mechanisms. This paper proposes a novel theoretical framework in which consciousness is conceptualized as a nonlocal field influenced by brain energy dynamics. By introducing the construct of neurentelechy, a measure of energy dissipation associated with conscious content, the model formalizes how...
Preprints.org
July 2, 2026
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The Default Mode Network and Emotional Processing: A Narrative Review of Lesion and Neuroimaging Studies
Preprints.org
June 30, 2026
Dirk Revenstorf, Joost (j.b.c.) Mertens, Martin Schipplick
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The therapeutic use of ketamine and other psychoactive substances in psychiatry is attracting growing research interest, particularly in treatment-resistant depression and related conditions refractory to conventional care. Ketamine exerts direct pharmacological antidepressant effects through NMDA receptor antagonism and downstream neuroplastic mechanisms; its combination with structured...
Preprints.org
June 26, 2026
Luís Eduardo Magro de Queiroz
preprint
This article proposes a biophysical theory of consciousness based on a formal equivalence between mass, energy, and informational organization derived from the coupling energy between the brain and a nonlocal phenomenological field, the q-field. Consciousness is conceived as a form of functional matter, whose phenomenological mass results from the difference between the total metabolic energy...
Preprints.org
June 25, 2026
Hudson Augusto Rodrigues Bonomo
preprint
A Large Language Model fabricated a reference to Ferenczi: plausible title, believable date, convincing page number, all false. Starting from this scene, this essay traces a genealogy from the Cartesian evil demon to the LLM as a technical realisation of the closed-cognition fantasy, and interrogates a presupposition shared, in different ways, by Putnam's brain-in-a-vat thought experiment,...
Preprints.org
June 23, 2026
Arosh S. Perera Molligoda Arachchige, Afanasy Svet, Maria Svet
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Understanding consciousness remains one of the most significant challenges in neuroscience, philosophy, and cognitive science. Despite substantial advances in neuroimaging, electrophysiology, and computational modeling, a comprehensive account of the neural basis of conscious experience has yet to emerge. This review examines several leading contemporary theories of consciousness, including the...
Preprints.org
June 22, 2026
Andrzej Günther, Barbara Bednarczyk-Cwynar
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Amanita muscaria is one of the most recognizable toxic mushrooms, yet its chemical and toxicological variability remains insufficiently understood. Its principal neuroactive isoxazole compounds, ibotenic acid and muscimol, differ substantially in pharmacological profile: ibotenic acid is associated mainly with glutamatergic excitatory activity, whereas muscimol is a potent GABAergic compound....
Preprints.org
June 17, 2026
Daniel Holguin
preprint
Four clinical literatures — psychedelic-assisted therapy, accelerated transcranial magnetic stimulation, closed-loop deep brain stimulation, and reconsolidation-based trauma therapy — produce durable change from brief, often single, interventions in conditions the current standard of care has not solved. The convergence is not procedural. Each modality transiently induces a high-plasticity...
Preprints.org
June 10, 2026
Marcelo Kuna
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This essay discusses feminist ideas in connection to the occulture present in opera, musical theatre, and film, focusing on femme fatales, tricksters and ‘wicked women’ in a transcultural approach to religion, (Western) esotericism, and the performing arts. A culturally critic debate is facilitated here via the spiritual-scientific embodiment of Afro-Brazilian traditions, as seen through the...
Preprints.org
June 9, 2026
Karthik Murugadoss, A.J. Venkatakrishnan, Venky Soundararajan
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Semaglutide and tirzepatide are typically evaluated through dose escalation, yet many patients in routine care do not reach a recommended maintenance dose due to tolerability, access, cost, supply or individualized goals. Here we used sustained 0.25 mg-only semaglutide and sustained 2.5 mg-only tirzepatide exposures as real-world proxies for “microdosing” and analyzed de-identified electronic...
Preprints.org
May 5, 2026
Houssaïnatou Bah, Aboubacar Sidiki Magassouba, Mahamoud Sama Cherif et al.
preprint
Sleep paralysis (SP) is characterized by a temporary inability to move or speak while awake. Although SP is prevalent among students, it remains understudied in sub-Saharan Africa. Medical students may be particularly vulnerable. In 2025, a survey was conducted among 320 medical science students at three universities in Conakry, Guinea, using a semi-structured electronic questionnaire. Data...
Preprints.org
April 29, 2026
Stefano Marini, Domenico de Berardis
preprint
Psychedelic drugs are serotonergic hallucinogens that can be divided into two types: naturally occurring (psilocybin, psilocin, and N,N-dimethyltryptamine) and synthetic (LSD, MDMA, 2,5-dimethoxy-4-iodoamphetamine, and ketamine). Psychedelics generally work on 5-hydroxytryptamine receptors and might be useful in cognitive enhancement, brain connectivity, neuroplasticity, and neuronal...
Preprints.org
April 27, 2026
Luis Miguel Gallardo
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Ancient contemplative traditions offer sophisticated technologies for cultivating stable states of consciousness underlying sustainable well-being. This integrative review synthesizes empirical and theoretical literature on Patañjali’s Sanyam—the integrated practice of Dharana (concentration), Dhyana (meditative absorption), and Samadhi (non-dual awareness)—and its Zen parallel, Joriki...
Preprints.org
April 21, 2026
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This paper proposes Functional Consciousness (FC) as a measurable architectural property: the observable capacity of a system to access and reason about internal representations of its own states. We introduce a computationally tractable metric on FC that operationalizes core tenets of major consciousness theories through self-models and their associated reasoning power, measured through...
Preprints.org
April 20, 2026
Octavian Victor Brinzei
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In the past year, the medical regulation of psilocybin-assisted therapy has expanded across additional international jurisdictions, requiring an update to the original medico-legal synthesis. Newly established or clarified regulatory pathways in New Zealand, Germany, Switzerland, the Czech Republic, and at the United States federal level reflect continued evolution in therapeutic governance....