Psychotherapy and Psychosomatics
June 12, 2026
Thorsten Barnhofer, Maria Niemi, Johannes Michalak et al.
1 citation
INTRODUCTION: Around a third of patients with major depressive disorder experience persistent symptoms despite usual treatments. Identifying scalable, psychological treatment options is critical to reduce the burden associated with difficult-to-treat depression (DTD). We examined the efficacy of mindfulness-based cognitive therapy (MBCT) compared with treatment as usual (TAU) and other active...
Psycho-oncology
September 1, 2025
Nasim Badaghi, Linda Kwakkenbos, Judith Prins et al.
Online mindfulness-based cognitive therapy (eMBCT) can reduce psychological distress in people with cancer, but adherence and scalability could be improved. Through co-creation, we developed two eMBCT formats: group-blended and individual-unguided. This trial compared the effects of the two eMBCT to care as usual (CAU) on psychological distress and other mental health outcomes in people with...
Inflammatory bowel diseases
July 14, 2025
Milou M Ter Avest, Marloes J. Huijbers, Carmen S Horjus et al.
6 citations
Many patients with inflammatory bowel disease (IBD) suffer from psychological distress, sleep disturbances, fatigue, and a reduced quality of life-even during remission. Mindfulness-Based Cognitive Therapy (MBCT) has been effective in other populations, and therefore it may also benefit IBD patients. The primary objective was to evaluate the effectiveness of MBCT plus treatment as usual (TAU)...
Journal of General Internal Medicine
May 19, 2025
Marieke Arts-De Jong, Dirk E. M. Geurts, Philip Spinhoven et al.
2 citations
The COVID-19 pandemic significantly impacted the mental health of frontline healthcare workers (HCWs), but solid evidence on psychological interventions for HCWs remains limited. Whether an adjusted therapist-assisted Mindfulness-based Stress Reduction group intervention (adjusted MBSR) is superior to a minimal self-guided mindfulness-based intervention (self-guided MBI) in improving mental...
Mindfulness
May 10, 2025
Charlotte Borgers, Johan C. Karremans, Anne E. M. Speckens
Abstract Objectives An important element of mindfulness-based interventions is daily at-home mindfulness practice. However, maintaining regular practice is a challenge for many participants. This study examined the influence of a dyadic support intervention—a “buddy intervention”—on adherence to mindfulness practice in terms of practice frequency and duration. Method In this quasi-experimental...
BMC Psychiatry
February 14, 2025
Maud Schepers, Paul Lagerweij, Dirk E. M. Geurts et al.
2 citations
Internalizing problems, such as worrying, anxiety and low mood, are increasingly common in youth and may constitute an early stage of mental illness development. There is thus an urgent need for effective measures to address mental health complaints as they develop and to prevent progression into more serious mental illness. Enhanced understanding of early-stage mental illness development,...
Journal of neurology
July 1, 2024
Ilse M Nauta, Maureen Van Dam, Dirk Bertens et al.
20 citations
Multiple sclerosis (MS) frequently gives rise to depressive and anxiety symptoms, but these are often undertreated. This study investigated the effect of mindfulness-based cognitive therapy (MBCT) and cognitive rehabilitation therapy (CRT) on psychological outcomes and quality of life (QoL), and whether they mediate treatment effects on MS-related cognitive problems. This randomized controlled...
Mindfulness
July 1, 2024
Jelle Lubbers, Philip Spinhoven, Mira B. Cladder-Micus et al.
Abstract Objectives Mindfulness-Based Cognitive Therapy (MBCT) reduces recurrence and current depressive symptoms in patients with major depressive disorder (MDD). To understand how and for whom MBCT works, a person-centered approach focusing on mindfulness profiles can be useful. Four mindfulness profiles, each associated differently with mental health outcomes, have previously been...
BMC Neurology
June 25, 2024
Anouk Van der Heide, Franziska Goltz, Nienke M De Vries et al.
5 citations
People with Parkinson's disease (PD) are very sensitive to the effects of stress. The prevalence of stress-related neuropsychiatric symptoms is high, and acute stress worsens motor symptoms. Animal studies suggest that chronic stress may accelerate disease progression, but evidence for this in humans is lacking. Mindfulness-based interventions (MBIs) train participants to focus on the present...
Frontiers in Education
April 9, 2024
Johanna H. Lensen, Sabine E. M. J. Stoltz, Marloes Kleinjan et al.
Educators frequently grapple with elevated levels of job-related stress, heightening the risk of mental health issues. Although Mindfulness-Based Stress Reduction (MBSR) has demonstrated effectiveness in reducing stress among the general populace, its implementation among educators, especially in non-United States settings, has received limited exploration. This pre-registered...
Mindfulness
February 1, 2024
Jelle Lubbers, Philip Spinhoven, Mira B. Cladder-Micus et al.
Abstract Objectives Mindfulness is a multifaceted concept which might be best captured by person-centered profiles rather than by variable-centered assessment of its subcomponents. Patients with different mindfulness profiles may vary in mental health status and might experience differential clinical outcomes of Mindfulness-Based Cognitive Therapy (MBCT). We therefore aimed to assess the...
Depression and Anxiety
2024
Jelle Lubbers, Dirk E. M. Geurts, Philip Spinhoven et al.
10 citations
Background: Mindfulness-based cognitive therapy (MBCT) is effective in reducing depressive symptoms in patients with major depressive disorder (MDD). Understanding for whom and how MBCT works may allow for improvements in treatment allocation and effectiveness. In this study, our aim was to investigate depressive rumination, content-independent perseverative thinking, mindfulness skills, and...
Psychological Medicine
October 1, 2023
Imke Hanssen, Marloes J. Huijbers, Eline Regeer et al.
7 citations
Mindfulness-based cognitive therapy (MBCT) seems a promising intervention for bipolar disorder (BD), but there is a lack of randomised controlled trials (RCT) investigating this. The purpose of this multicentre, evaluator blinded RCT was to investigate the added value of MBCT to treatment as usual (TAU) in BD up to 15 months follow-up (NCT03507647). A total of 144 participants with BD type I...
International Journal of Methods in Psychiatric Research
September 12, 2023
Ben Wijnen, Maud Jansen, Annelieke Van Velthoven et al.
2 citations
Aim of this study was to assess the cost-effectiveness and cost-utility of mindfulness-based cognitive therapy (MBCT) and treatment as usual (TAU) compared to TAU alone in adults with Bipolar disorder (BD). An economic evaluation with a time horizon of 15 months was conducted from a societal perspective. Outcomes were expressed in costs per quality adjusted life years (QALYs) and costs per...
Nature. Mental health
July 10, 2023
Julieta Galante, Claire Friedrich, Napaporn Aeamla-Or et al.
102 citations
Mindfulness-based programmes (MBPs) are widely used to prevent mental ill-health that is becoming the leading global cause of morbidity. Evidence suggests beneficial average effects but wide variability. We aimed to confirm the effect of MBPs on psychological distress, and to understand whether and how baseline distress, gender, age, education, and dispositional mindfulness modify the effect of...
Brain and Behavior
May 24, 2023
Hannah Ellerbroek, Imke Hanssen, Karen Lathouwers et al.
Mindfulness‐based interventions have a positive impact on pain, craving, and well‐being in both patients with chronic pain and those with opioid use disorder (OUD). Although data are limited, mindfulness‐based cognitive therapy (MBCT) might be a promising treatment for patients with chronic noncancer pain combined with OUD. The aim of this qualitative study was to explore the feasibility and...
Journal of Affective Disorders
May 1, 2023
Mira B. Cladder-Micus, J. Vrijsen, A. Fest et al.
BACKGROUND Mindfulness-based cognitive therapy (MBCT) is an evidence-based treatment for depression. The current study focused on the long-term effects of MBCT for chronically, treatment-resistant depressed patients during a 6-months follow-up period. Additionally, predictors of treatment outcomes were explored. METHOD The outcomes of MBCT on depressive symptoms, remission rates, quality of...
BJPsych Open
March 9, 2023
Dirk E. M. Geurts, Felix R. Compen, Marleen H.C.T. van Beek et al.
Background Meta-analyses show efficacy of mindfulness-based cognitive therapy (MBCT) in terms of relapse prevention and depressive symptom reduction in patients with major depressive disorder (MDD). However, most studies have been conducted in controlled research settings. Aims We aimed to investigate the effectiveness of MBCT in patients with MDD presenting in real-world clinical practice....
PLoS One
2023
Marloes J. Huijbers, Carolien Wentink, Peter L B J Lucassen et al.
Discontinuing antidepressant medication (ADM) can be challenging for patients and clinicians. In the current study we investigated if Mindfulness-Based Cognitive Therapy (MBCT) added to supported protocolized discontinuation (SPD) is more effective than SPD alone to help patients discontinue ADM. This study describes a prospective, cluster-randomized controlled trial (completed). From 151...
Cognition & Emotion
December 22, 2021
Thalia D.M. Stalmeier, Jelle Lubbers, Mira B. Cladder-Micus et al.
ABSTRACT Negative self-referential processing has fruitfully been studied in unipolar depressed patients, but remarkably less in patients with bipolar disorder (BD). This exploratory study examines the relation between task-based self-referential processing and depressive symptoms in BD and their possible importance to the working mechanism of mindfulness-based cognitive therapy (MBCT) for BD....
PLoS One
December 2, 2021
Imke Hanssen, Vera Scheepbouwer, Marloes J. Huijbers et al.
12 citations
BackgroundMindfulness-Based Interventions (MBIs) are widely used in clinical and non-clinical populations, but little attention has been given to potential adverse effects (AEs).AimsThis study aimed to gain insight in the prevalence and course of AEs during Mindfulness-Based Cognitive Therapy (MBCT) for patients with bipolar disorder (BD).MethodThe current mixed-methods study was conducted as...
Depression and Anxiety
November 9, 2021
J. D. de Klerk-Sluis, Marloes J. Huijbers, S. Löcke et al.
Mindfulness‐based cognitive therapy (MBCT) is effective for relapse prevention in major depressive disorder (MDD). It reduces cognitive reactivity (CR) and rumination, and enhances self‐compassion and mindfulness. Although rumination and mindfulness after MBCT are associated with relapse, the association of CR, rumination, self‐compassion, and mindfulness with relapse before initiation of MBCT...
BMJ Open
November 12, 2020
Marloes J Huijbers, Carolien Wentink, Anne Speckens et al.
Objectives This study aimed to explore predictors and outcomes associated with different trajectories of discontinuing antidepressant medication (ADM), in recurrently depressed individuals after participation in mindfulness-based cognitive therapy (MBCT). Facilitators and barriers of discontinuation were explored qualitatively.Design Mixed-methods study combining quantitative and qualitative...
Mindfulness
October 1, 2020
Marleen J. Ter Avest, Corina U. Greven, Marloes J. Huijbers et al.
Abstract Objectives Gaining knowledge of dynamic processes of mechanisms underlying mindfulness-based cognitive therapy (MBCT) for recurrent depression could help to improve treatment efficacy. The current study examined the overall course and week-to-week associations of mindfulness and positive/negative affect during MBCT for recurrent depression. Methods Using data from the MOMENT study, 235...
Journal of Attention Disorders
January 6, 2020
Dirk E. M. Geurts, Melanie P. J. Schellekens, L. Janssen et al.
Objective: Mindfulness-based cognitive therapy (MBCT) has been demonstrated to be effective in adults with ADHD. The aim of the current study was to examine its possible working mechanisms. Method: In the context of an randomized controlled trial (RCT), MBCT + TAU (treatment as usual) (n = 43) versus TAU (n = 51), we used mediation analyses to examine whether reduction of clinician-rated ADHD...