Efficacy and moderators of mindfulness-based cognitive therapy (MBCT) in 'Difficult to Treat' depression: protocol for a systematic review and individual participant data meta-analysis of randomised controlled trials.

Mindfulness-based cognitive therapy (MBCT) may help people with depression that is difficult to treat. This protocol describes a planned systematic review and individual participant data meta-analysis of randomised controlled trials to assess MBCT's efficacy and identify which patient characteristics predict better outcomes. The analysis will combine raw data from multiple trials to determine whether MBCT reduces depressive symptoms and relapse in this challenging population, and to explore moderators such as depression severity, number of previous episodes, and childhood adversity. The results should clarify for whom MBCT works best and inform clinical decision-making for treatment-resistant depression.

Study at a glance

Abstract

Efficacy and moderators of mindfulness-based cognitive therapy (MBCT) in 'Difficult to Treat' depression: protocol for a systematic review and individual participant data meta-analysis of randomised controlled trials.