Mindfulness
August 14, 2026
Milou M Ter Avest, Loes HC Nissen, Sabien JE Bosman et al.
Abstract Objectives The high psychological burden of inflammatory bowel diseases (IBD) underscores the need for effective and feasible psychological treatment options. This study aimed to explore the acceptability and feasibility of mindfulness-based cognitive therapy (MBCT) for adults with IBD. Method This mixed-methods study was embedded in a multicenter randomized controlled trial on the...
Inflammatory bowel diseases
July 14, 2025
Milou M Ter Avest, Marloes J. Huijbers, Carmen S Horjus et al.
6 citations
Many patients with inflammatory bowel disease (IBD) suffer from psychological distress, sleep disturbances, fatigue, and a reduced quality of life-even during remission. Mindfulness-Based Cognitive Therapy (MBCT) has been effective in other populations, and therefore it may also benefit IBD patients. The primary objective was to evaluate the effectiveness of MBCT plus treatment as usual (TAU)...
Psychological Medicine
October 1, 2023
Imke Hanssen, Marloes J. Huijbers, Eline Regeer et al.
7 citations
Mindfulness-based cognitive therapy (MBCT) seems a promising intervention for bipolar disorder (BD), but there is a lack of randomised controlled trials (RCT) investigating this. The purpose of this multicentre, evaluator blinded RCT was to investigate the added value of MBCT to treatment as usual (TAU) in BD up to 15 months follow-up (NCT03507647). A total of 144 participants with BD type I...
International Journal of Methods in Psychiatric Research
September 12, 2023
Ben Wijnen, Maud Jansen, Annelieke Van Velthoven et al.
2 citations
Aim of this study was to assess the cost-effectiveness and cost-utility of mindfulness-based cognitive therapy (MBCT) and treatment as usual (TAU) compared to TAU alone in adults with Bipolar disorder (BD). An economic evaluation with a time horizon of 15 months was conducted from a societal perspective. Outcomes were expressed in costs per quality adjusted life years (QALYs) and costs per...
PLoS One
2023
Marloes J. Huijbers, Carolien Wentink, Peter L B J Lucassen et al.
Discontinuing antidepressant medication (ADM) can be challenging for patients and clinicians. In the current study we investigated if Mindfulness-Based Cognitive Therapy (MBCT) added to supported protocolized discontinuation (SPD) is more effective than SPD alone to help patients discontinue ADM. This study describes a prospective, cluster-randomized controlled trial (completed). From 151...
Cognition & Emotion
December 22, 2021
Thalia D.M. Stalmeier, Jelle Lubbers, Mira B. Cladder-Micus et al.
ABSTRACT Negative self-referential processing has fruitfully been studied in unipolar depressed patients, but remarkably less in patients with bipolar disorder (BD). This exploratory study examines the relation between task-based self-referential processing and depressive symptoms in BD and their possible importance to the working mechanism of mindfulness-based cognitive therapy (MBCT) for BD....
PLoS One
December 2, 2021
Imke Hanssen, Vera Scheepbouwer, Marloes J. Huijbers et al.
12 citations
BackgroundMindfulness-Based Interventions (MBIs) are widely used in clinical and non-clinical populations, but little attention has been given to potential adverse effects (AEs).AimsThis study aimed to gain insight in the prevalence and course of AEs during Mindfulness-Based Cognitive Therapy (MBCT) for patients with bipolar disorder (BD).MethodThe current mixed-methods study was conducted as...
Depression and Anxiety
November 9, 2021
J. D. de Klerk-Sluis, Marloes J. Huijbers, S. Löcke et al.
Mindfulness‐based cognitive therapy (MBCT) is effective for relapse prevention in major depressive disorder (MDD). It reduces cognitive reactivity (CR) and rumination, and enhances self‐compassion and mindfulness. Although rumination and mindfulness after MBCT are associated with relapse, the association of CR, rumination, self‐compassion, and mindfulness with relapse before initiation of MBCT...
BMJ Open
November 12, 2020
Marloes J Huijbers, Carolien Wentink, Anne Speckens et al.
Objectives This study aimed to explore predictors and outcomes associated with different trajectories of discontinuing antidepressant medication (ADM), in recurrently depressed individuals after participation in mindfulness-based cognitive therapy (MBCT). Facilitators and barriers of discontinuation were explored qualitatively.Design Mixed-methods study combining quantitative and qualitative...
Mindfulness
October 1, 2020
Marleen J. Ter Avest, Corina U. Greven, Marloes J. Huijbers et al.
Abstract Objectives Gaining knowledge of dynamic processes of mechanisms underlying mindfulness-based cognitive therapy (MBCT) for recurrent depression could help to improve treatment efficacy. The current study examined the overall course and week-to-week associations of mindfulness and positive/negative affect during MBCT for recurrent depression. Methods Using data from the MOMENT study, 235...
Mindfulness
January 12, 2017
Marloes J. Huijbers, R. Crane, Willem Kuyken et al.
As mindfulness-based cognitive therapy (MBCT) becomes an increasingly mainstream approach for recurrent depression, there is a growing need for practitioners who are able to teach MBCT. The requirements for being competent as a mindfulness-based teacher include personal meditation practice and at least a year of additional professional training. This study is the first to investigate the...
JAMA Psychiatry
April 28, 2016
Willem Kuyken, Fiona C Warren, Rod S. Taylor et al.
815 citations
IMPORTANCE: Relapse prevention in recurrent depression is a significant public health problem, and antidepressants are the current first-line treatment approach. Identifying an equally efficacious nonpharmacological intervention would be an important development. OBJECTIVE: To conduct a meta-analysis on individual patient data to examine the efficacy of mindfulness-based cognitive therapy...
Thalia D.M. Stalmeier, Jelle Lubbers, Mira B. Cladder-Micus et al.
Abstract Background: Negative self-referential processing has fruitfully been studied in unipolar depressed patients, but remarkably less in patients with bipolar disorder (BD). This study examines the relation between task-based self-referential processing and depressive symptoms in BD and their possible importance to the working mechanism of mindfulness-based cognitive therapy (MBCT) for...