BMC Psychiatry
August 19, 2026
Adam O’Neill, Gillian Haddock, Kate Stalker et al.
Abstract Background Non-affective psychosis is associated with elevated risk of suicide, self-harm, and reduced life expectancy. Symptoms of dissociation are common in non-affective psychosis, and dissociative experiences are known to be linked to multiple markers of elevated clinical risk, including sleep disturbance and negative affect. The present review represents the first comprehensive...
BMC Psychiatry
August 5, 2026
Xiang Liu, Yuanzhi He, Lifeng Li et al.
Abstract Introduction Major depressive disorder (MDD) is characterized by dysfunction in higher-order cortical regions involved in emotional and cognitive processes; however, its neurobiological basis remains unclear. Pharmacological treatments, including esketamine and sertraline, produce rapid antidepressant effects. We investigated the local intrinsic neural dynamics underlying these...
BMC Psychiatry
June 4, 2026
Sachin Shah, Hamilton Morrin
This case describes a substance-induced manic episode with psychotic features in which interaction with an AI (artificial intelligence) chatbot appeared to corroborate and reinforce the patient's delusional thought content and to contradict medical advice. Excerpts from the patient's interactions with the AI chatbot provide novel clinical insight into this phenomenon, which to date has...
BMC Psychiatry
June 3, 2026
Ya-Jing Tang, Lei Yang, Wen-Hao Wang et al.
The subjective lived experience of schizophrenia among China's Z Generation (born 1995-2009) remains understudied. This population navigates a unique socio-cultural context, making their personal narratives crucial for developing effective, person-centered mental health interventions. We employed a descriptive phenomenological approach, conducting in-depth interviews with four Chinese...
BMC Psychiatry
April 26, 2026
Sergi López-rodríguez, Cinto Segalàs, Eva Real et al.
BACKGROUND: Patients with obsessive–compulsive disorder (OCD) and comorbid major depressive disorder (MDD) represent a severe subgroup with increased treatment resistance, greater functional impairment, and limited therapeutic options. Intranasal esketamine is a rapidly acting treatment for resistant depression, with emerging interest in potential anti-obsessional effects. However, prospective...
BMC Psychiatry
April 6, 2026
Michael Schlegelmilch, Amy C. Plint, Nicholas Barrowman et al.
BACKGROUND: Suicidal ideation (SI) is a common reason for emergency department (ED) visits by adolescents. While intravenous (IV) ketamine rapidly reduces SI in adults, its efficacy in adolescents remains unstudied. We assessed the feasibility of a trial of a single dose IV ketamine to reduce adolescent SI in the ED. METHODS: This double-blind, randomized, placebo-controlled pilot trial was...
BMC Psychiatry
March 17, 2026
Bernhard T Baune, Kevin Rosemann, Dimitri Hefter et al.
2 citations
Intranasal esketamine: real-world clinical practice in treatment-resistant depression and factors associated with treatment response.
BMC Psychiatry
February 2, 2026
Living with psychosis and cognitive impairment: a qualitative study.
BMC Psychiatry
January 16, 2026
Leonie Ascone, Candelaria Mahlke, Nour Tawil et al.
2 citations
In acute psychiatric inpatient settings, where perception is altered and emotional vulnerability is heightened, many facilities use coercive seclusion rooms for safety. This practice has been increasingly criticized for its psychological impact. While architectural guidelines emphasize human-centered and biophilic design to support well-being, empirical evidence on how design features in this...
BMC Psychiatry
January 4, 2026
Carl D. Marci, Kruti Joshi, Stevan Geoffrey Severtson et al.
2 citations
Abstract Background Treatment-resistant depression (TRD) is often characterized by inadequate response to ≥ 2 oral antidepressant treatments of adequate dose and duration during a major depressive episode (MDE). Esketamine nasal spray (ESK) was approved by the US Food and Drug Administration in 2019 for TRD in conjunction with an oral antidepressant under a Risk Evaluation and Mitigation...
BMC Psychiatry
November 26, 2025
Lyn Ellett, Laura Dannahy, Kate Bennett et al.
Schizophrenia is a severe mental illness with a significant disease, economic and social burden. Persecutory delusions (beliefs that one will be harmed or mistreated) are a common symptom of schizophrenia with associated high levels of depression. International clinical guidelines recommend individual cognitive behaviour therapy for schizophrenia, but there are currently no group psychological...
BMC Psychiatry
November 3, 2025
Ahmet Selim Başaran, Hande Gazey, Sena Çağlayan et al.
BACKGROUND: Politically charged public life supplies powerful symbols that can be recruited into delusional meaning-making. This study examined how political contexts shape the content and experiential structure of delusions in patients with psychotic disorders in Turkey. METHODS: We conducted a retrospective, archive-based qualitative study of inpatient psychiatric records from a tertiary...
BMC Psychiatry
July 1, 2025
E van Weert, H J De Vuyst, Katleen van der Gucht et al.
Oxytocin administration is increasingly considered a novel therapeutic support option for alleviating psychological distress in stress-related neuropsychiatric conditions, including anxiety disorders and depression. However, oxytocin as a stand-alone treatment may fail to consistently target the relevant central autonomic circuitry without a complementary supportive therapeutic context that...
BMC Psychiatry
June 4, 2025
Yuekun Wu, Yue Ban, Guoliang Pan et al.
6 citations
Psychiatric healthcare workers experience prolonged exposure to psychological trauma and negative emotions, which ultimately predisposes them to mental health issues. The effectiveness of online mindfulness-based stress reduction training on depression and anxiety symptoms among psychiatric healthcare workers (HCWs) and the possible mechanisms that benefit these outcomes remain unclear. This...
BMC Psychiatry
May 20, 2025
Qi Sun, Kaiyuan Jing, Xiaoxiao Xu et al.
Despite extensive research on mindfulness, there is a dearth of studies exploring its impact on post-traumatic stress disorder (PTSD) through the intermediaries of psychological resilience and perceived stress. In response to a violent campus event, this article investigates the association between mindfulness levels among college students and the presence of PTSD using a sequential mediation...
BMC Psychiatry
May 12, 2025
Zouqing Lin, Xiaoyan Xu, Kai Zhang et al.
3 citations
To analyze the symptoms, courses, and severities of depressive disorder, as well as the morphological changes in the spleens and related immune mechanisms, we recruited patients with first-episode or recurrent major depressive disorder (MDD) (patient group) and healthy controls (normal group) matched in age and gender. We measured their plasma MICB (pg/ml), ULBP1 (ng/ml), and splenic volume...
BMC Psychiatry
April 1, 2025
Danielle Moskow Diamond, Joshua Curtiss, Joseph K. Carpenter et al.
4 citations
Many individuals who engage in mindfulness experience decreased anxiety. Yet some individuals, particularly those with panic disorder (PD) or elevated anxiety sensitivity (AS), note heightened anxiety when observing particular sensations. The Five Facet Mindfulness Questionnaire (FFMQ) is one of the most widely utilized mindfulness questionnaires. However, its Observe facet has shown...
BMC Psychiatry
February 28, 2025
John Perna, Justin Trop, Roman Palitsky et al.
15 citations
This case highlights the tensions between legal and underground psychedelic use within psychedelic therapy training programs, psychiatry and neo-shamanism, and the use of psychiatric interventions (i.e., ECT) and energy medicine to address prolonged adverse effects from psychedelics. Clinicians should be aware of these potential conflicts between psychiatric conceptualizations of PAEs and...
BMC Psychiatry
February 14, 2025
Maud Schepers, Paul Lagerweij, Dirk E. M. Geurts et al.
2 citations
Internalizing problems, such as worrying, anxiety and low mood, are increasingly common in youth and may constitute an early stage of mental illness development. There is thus an urgent need for effective measures to address mental health complaints as they develop and to prevent progression into more serious mental illness. Enhanced understanding of early-stage mental illness development,...
BMC Psychiatry
January 7, 2025
Katelyn Halpape, Raelle Pashovitz, Annabelle Wanson et al.
4 citations
Ketamine is a promising therapy for treatment-resistant depression due to its rapid onset, although benefits are often transitory, with patients needing maintenance therapy to prevent relapse. Most data supporting ketamine for treatment-resistant depression refers to the intravenous route of administration, leaving alternative routes lacking in data, especially as maintenance regimens....
BMC Psychiatry
October 28, 2024
Sumaya Jobnah, Youssef Latifeh, Dina Al Kabani et al.
2 citations
Chronic treatment-resistant depression (TRD) poses a major challenge for clinicians. Ketamine has shown a rapid but short-lived antidepressant effect in several studies involving TRD patients with different demographic and clinical profiles. Our study aimed to assess the antidepressant effect of serial infusion sessions of ketamine in patients with chronic TRD and evaluate the severity of...
BMC Psychiatry
October 14, 2024
Sisi Zheng, Francis Xiatian Zhang, Hubert P H Shum et al.
5 citations
Depersonalization-Derealization Disorder (DPD), a prevalent psychiatric disorder, fundamentally disrupts self-consciousness and could significantly impact the quality of life of those affected. While existing research has provided foundational insights for this disorder, the limited exploration of brain dynamics in DPD hinders a deeper understanding of its mechanisms. It restricts the...
BMC Psychiatry
September 27, 2024
Onrumpha Chuenchom, Thanarat Suansanae, Lumsum Lukanapichonchut et al.
Abstract Background Current treatment of cannabis-induced psychosis (CIP) focus on the presenting symptoms of individual patient. Therefore, the objective of this study was to investigate the efficacy of pharmacological treatment for CIP in a retrospective manner. Methods A retrospective chart review study was conducted at the Princess Mother National Institute on Drug Abuse Treatment...
BMC Psychiatry
August 9, 2024
Psychometric properties of the Arabic version of the Nightmares Distress Questionnaire (NDQ-AV) in a community sample of adolescents.
BMC Psychiatry
July 18, 2024
Keerati Pattanaseri, Juthawadee Lortrakul, Kankamol Jaisin et al.
11 citations
Studies have confirmed the rapid antidepressant action of ketamine in depressive episodes. Nevertheless, a standardized procedure for the delivery of ketamine infusion in individuals suffering from treatment-resistant depression, particularly in terms of infusion frequency and total dosage, remains undetermined. In addition, an efficacious ketamine regimen for persistent pain management...