Group-Delivered Mindfulness-Based Cognitive Therapy to Reduce Psychological Distress and Improve Sleep in Patients With Inflammatory Bowel Diseases: A Multicenter Randomized Controlled Trial (MindIBD).
Milou M Ter Avest, Marloes J. Huijbers, Carmen S Horjus, Tessa E H Römkens, Ellen M Witteman, Willemijn A van Dop, Martin Dresler, A Rogier T Donders, Gerard Dijkstra, Loes H C Nissen, Anne E. M. Speckens
Inflammatory bowel diseases July 14, 2025 DOI: 10.1093/ibd/izaf116 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 142 |
| Population | IBD patients in remission, aged 16 and older, with at least mild psychological distress |
| Intervention | Mindfulness-Based Cognitive Therapy |
| Duration | 3-month intervention, follow-up at 6, 9, and 12 months after baseline |
| Topics | Meditation |
| Keywords | Mindfulness-based cognitive therapy Inflammatory bowel diseases Psychological distress Randomized controlled trial Mindfulness therapy Psychological intervention Stress reduction therapy Mental health therapy Ibd Chronic inflammatory conditions Gut health Digestive disorders Psychological well-being Emotional health Quality of life Sleep quality Distress alleviation Rct Clinical trial Medical research Evidence-based study |
| Citations | 6 |
| Registration | NCT04646785 |
| Key findings | MBCT plus treatment as usual reduced psychological distress and improved well-being compared to treatment as usual alone, with some effects on sleep and inflammation markers. |
Abstract
Many patients with inflammatory bowel disease (IBD) suffer from psychological distress, sleep disturbances, fatigue, and a reduced quality of life-even during remission. Mindfulness-Based Cognitive Therapy (MBCT) has been effective in other populations, and therefore it may also benefit IBD patients. The primary objective was to evaluate the effectiveness of MBCT plus treatment as usual (TAU) in reducing psychological distress compared to TAU alone. This multicenter randomized controlled trial study included IBD patients in remission, aged 16 and older, who experienced at least mild levels of psychological distress (Hospital Anxiety and Depression Scale ≥ 11). Assessments were conducted at baseline, post-intervention (3 months), and at 6, 9, and 12 months after baseline. This trial was registered at ClinicalTrials.gov: NCT04646785. A total of 142 participants were allocated to MBCT + TAU (n = 70) or TAU alone (n = 72). Group-delivered MBCT significantly reduced psychological distress (d = -0.61) and improved well-being (d = 0.40) post-intervention, with consolidation of the effects over time. Exploratory objective sleep metrics (ie, electroencephalography) showed a reduction in total sleep time (d = 0.67) after MBCT with an increase in the proportion of deep sleep (d = 0.70). While flare occurrence showed no difference, fecal calprotectin levels reduced in the MBCT + TAU group over the follow-up period (d = -0.49). Mindfulness-Based Cognitive Therapy can be considered a valuable addition to the limited effective psychosocial interventions set for IBD patients, as it reduces psychological distress and improves well-being. This study also shows the possible impact of MBCT on biological processes, such as sleep and inflammation.