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Willem Kuyken

70 papers in the library · 4,015 citations · publishing 2009-2026

Papers

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Adolescents and carers using mindfulness Therapy To END depression (ATTEND): study protocol for a parallel randomised controlled superiority trial of Mindfulness for Adolescents and Carers (MAC) for depression among young people aged 15 to 18 years old with an embedded economic evaluation

Trials October 23, 2026 Tamsin Ford, Rachel Childs, Rachel Hayes et al.

Abstract: Background: Mindfulness-based cognitive therapy (MBCT) is a group intervention recommended by NICE for adults who have experienced recurrent depression but is untested for adolescents. MBCT aims to teach people to recognise early indicators of depression, to avoid repetitive thinking patterns that make relapse more likely, and to respond to stressors in ways that protect mental...

Adolescents and carers using mindfulness Therapy To END depression (ATTEND): Study Protocol for a parallel randomized controlled superiority trial of Mindfulness for Adolescents and Carers (MAC) for depression among young people aged 15 to 18 years old with an embedded economic evaluation

Research Portal October 13, 2026 Tamsin Ford, Rachel Childs, Rachel Hayes et al.

Adolescents and carers using mindfulness Therapy To END depression (ATTEND): Study Protocol for a parallel randomized controlled superiority trial of Mindfulness for Adolescents and Carers (MAC) for depression among young people aged 15 to 18 years old in the UK with an embedded economic evaluation.

Ecological-collective-flourishing (e-co-flourishing): a framework to guide innovation and research.

Lancet Planetary Health July 1, 2026 Shannon Maloney, Joseph Moore, Katrin Wilhelm et al.

Converging ecological and social crises have exposed the limits of prevailing models of human progress, highlighting the need for more inclusive and interdisciplinary approaches to advancing wellbeing and flourishing across human and non-human life. In this Personal View, we propose an ecological-collective-flourishing (e-co-flourishing) approach, whereby one's own human flourishing is pursued...

Changes in hierarchical brain dynamics of rumination following mindfulness-based cognitive therapy for depression

medRxiv June 23, 2026 Paulina Clara Dagnino, Anne Maj van der Velden, Henricus G. Ruhé et al. preprint

Abstract Major depressive disorder (MDD) is a leading cause of disability worldwide with risk of onset and recurrence linked to depressive ruminative thought patterns. Mindfulness-based cognitive therapy (MBCT) is an evidence-based treatment for depression that targets the ability to recognise, decenter, and disengage from ruminative thought patterns. Elucidating how MBCT impacts hierarchical...

A Pilot Study of a Mindfulness-Based Cognitive Therapy for Internet Gaming Disorder Among College-Aged Students in South Korea

Mindfulness June 1, 2026 Anderson Yoon, Yehwi Park, Min Ah Kim et al.

Abstract Objectives Mindfulness-based cognitive therapy (MBCT) integrates cognitive therapy and mindfulness meditation to help individuals disengage from maladaptive thoughts and reactive behavioral patterns. By cultivating nonjudgmental present-moment awareness and decentering from thoughts and emotions, MBCT enhances the capacity to respond more skillfully, thereby reducing impulsivity and...

Dynamic Repertoire of Brain Networks in Mindfulness-Based Cognitive Therapy During Rumination: A Randomized Controlled Trial

Biological Psychiatry Global Open Science May 14, 2026 Anne Maj van der Velden, Jakub Vohryzek, Paulina Clara Dagnino et al.

BACKGROUND Depression is a prevalent and debilitating affective disorder characterised by the dominance and persistence of depressive rumination. Mindfulness-based cognitive therapy (MBCT) is an effective treatment for recurrent depression developed specifically to target rumination and recurrence risk by training metacognitive awareness and adaptive attention, emotion and self-regulation...

DOI: 10.1016/j.bpsgos.2026.100753 (opens in new tab) Mindfulness Randomized controlled trial Cognition Repertoire +3

Predicting Adolescent Response to School-Based Mindfulness

Apollo (University of Cambridge) February 24, 2026 Christian A. Webb, Boyu Ren, Verena Hinze et al.

Importance: Depression most commonly first emerges during adolescence, making early prevention critical. While school-based mindfulness training (SBMT) offers a scalable prevention approach with broad reach, evidence of its effectiveness is mixed, and there is a compelling case for a more personalized approach to prevention. Objective: To develop a data-driven algorithm from baseline...

Adolescents' trajectories of mental health in the MYRIAD trial.

JCPP Advances October 7, 2025 Carolina Guzman Holst, Simona Skripkauskaite, Jack L. Andrews et al.

This study explored adolescent's mental health trajectories over the course of a school-based mindfulness-based intervention trial (MYRIAD). It examined whether intervention condition (mindfulness vs. teaching-as-usual), individual-level and contextual-level factors were associated with different trajectories. This pre-registered study used data from 11- to 14-year-olds who participated in the...

DOI: 10.1002/jcv2.70046 (opens in new tab) Full text (opens in new tab) Depression Adolescence Mindfulness training School-based interventions +1

Participants' Perspective on the Competence of Mindfulness-Based Interventions Teaching: Development and Validation of the Mindfulness-Based Interventions-Participants' Assessment of Teaching (MBI:PAT) Questionnaire.

Mindfulness September 3, 2025 Jesus Montero-Marin, Eleanor-Rose Farley, Shannon Maloney et al.

Objectives: No participant-rated tool exists for assessing MBI teaching competence. This study aimed to develop and validate the MBI:PAT to address this limitation. The primary objective was to develop a new measure, the Mindfulness-based Interventions: Participants' Assessment of Teaching" (MBI:PAT), and to evaluate its psychometric properties across several studies using independent samples....

DOI: 10.1007/s12671-025-02668-8 (opens in new tab) Full text (opens in new tab) Questionnaire Mindfulness-based Teaching competence Mbi

The effect of mindfulness interventions on couple relationship satisfaction: A systematic review and meta-analysis.

Journal of Consulting and Clinical Psychology June 1, 2025 Andreas Voldstad, Ananda Zeas-Sigüenza, Anton Skolzkov et al. 2 citations

Mindfulness interventions (MIs) train nonjudgmental attention to present-moment experience and aim to improve mental health and well-being. The evidence for their effect on interpersonal relationships is promising but uncertain. This study examines the effect of MIs on couple relationship satisfaction (RS). Randomized controlled trials of MIs including RS were selected based on systematic...

Examining what works for whom and how in mindfulness-based cognitive therapy (MBCT) for recurrent depression: moderated-mediation analysis in the PREVENT trial.

The British Journal of Psychiatry April 1, 2025 Jesus Montero-Marin, Verena Hinze, Shannon Maloney et al. 4 citations

Personalised management of recurrent depression, considering individual patient characteristics, is crucial. This study evaluates the potentially different mediating role of mindfulness skills in managing recurrent depression using mindfulness-based cognitive therapy (MBCT) among people with varying depression severity. Data from the Prevention of Depressive Relapse or Recurrence (PREVENT)...

DOI: 10.1192/bjp.2024.178 (opens in new tab) Full text (opens in new tab) Recurrent depression Depression severity Mindfulness skills Mindfulness-based cognitive therapy +1

Dynamical repertoire of brain networks in mindfulness cognitive behavioural therapy during rumination: A randomized controlled trial

medRxiv February 7, 2025 Jakub Vohryzek, Anne Maj van der Velden, Willem Kuyken et al. 1 citation preprint

BACKGROUND: Depression is a prevalent and debilitating affective disorder characterised by the dominance and persistence of depressive rumination. Mindfulness-based cognitive therapy (MBCT) is an effective treatment for recurrent depression developed specifically to target rumination and recurrence risk by training metacognitive awareness and adaptive attention, emotion and self-regulation...

The Mindful Way From Information to Knowledge, to Wisdom, and to Life: Perspectives on Mindfulness (-Based Cognitive Therapy) for Higher Education.

Mindfulness 2025 Marc-Henri Deroche, Willem Kuyken, Teruhisa Uwatoko et al. 5 citations

This article explores the potential relevance of Mindfulness-Based Programs, particularly Mindfulness-Based Cognitive Therapy (MBCT), to support the mission of higher education by facilitating the journey from information to knowledge, and from knowledge to wisdom. It thus addresses the problems of distractibility and superficial engagement caused by information overload and aims to prepare...

Mindfulness-Based Cognitive Therapy for Depression, Taking It Further (MBCT-D-TiF): An Assessment of an Intervention Development Study.

Global Advances in Integrative Medicine and Health 2025 Chelsea J Siwik, Jessica M. Harrison, Willem Kuyken et al.

Mindfulness-Based Cognitive Therapy (MBCT) reduces depression relapse, yet graduates have expressed a need for structured guidance post-program to maintain mindfulness practice and sustain benefits. To address this, we created MBCT for Depression-Taking it Further (MBCT-D-TiF). To refine and pilot test feasibility and acceptability of MBCT-D-TiF. We collected qualitative focus group data to...

Pathways to mental well-being for graduates of mindfulness-based cognitive therapy (MBCT) and mindfulness-based stress reduction (MBSR): A mediation analysis of an RCT.

Psychotherapy Research November 1, 2024 Shannon Maloney, Jesus Montero-Marin, Willem Kuyken 17 citations

To explore mediated effects of Mindfulness-Based Cognitive Therapy-"Taking it Further" (MBCT-TiF) on mental well-being through changes in mindfulness, self-compassion, and decentering. A secondary analysis of an RCT using simple mediation, with 164 graduates of MBCT and mindfulness-based stress reduction (MBSR), was implemented whereby MBCT-TiF (vs ongoing mindfulness practice; OMP) was the...

DOI: 10.1080/10503307.2023.2269299 (opens in new tab) Full text (opens in new tab) Mbct-tif Indirect effect Mediation Mental health +2

Does mindfulness-based cognitive therapy with tapering support reduce risk of relapse/recurrence in major depressive disorder by enhancing positive affect? A secondary analysis of the PREVENT trial.

Journal of Consulting and Clinical Psychology September 1, 2024 Barnaby D. Dunn, Laura Warbrick, Rachel Hayes et al. 10 citations

Mindfulness-based cognitive therapy (MBCT) is a viable alternative to maintenance antidepressant medication (M-ADM) to reduce risk of relapse/recurrence (RR) in recurrent depression, but its mechanism of action is not yet fully articulated. This secondary analysis of the PREVENT trial examined if MBCT with support to taper medication (MBCT-TS) reduces risk of RR in part by enhancing positive...

Target mechanisms of mindfulness-based programmes and practices: a scoping review.

BMJ mental health August 24, 2024 Shannon Maloney, Merle Kock, Yasmijn Slaghekke et al. 16 citations

Mindfulness-based programmes (MBPs) and practices have demonstrated effects in mental health and well-being, yet questions regarding the target mechanisms that drive change across the population remain unresolved. Five databases were searched for randomised controlled trials that evaluate the indirect effects (IEs) of an MBP or mindfulness practice in relation to mental health and well-being...

Mindfulness-Based Cognitive Therapy-Taking it Further (MBCT-TiF) compared to Ongoing Mindfulness Practice (OMP) in the promotion of well-being and mental health: A randomised controlled trial with graduates of MBCT and MBSR.

Behaviour Research and Therapy February 1, 2024 Shannon Maloney, Jesus Montero-Marin, Willem Kuyken

To evaluate the effectiveness and acceptability of Mindfulness-Based Cognitive Therapy-Taking it Further (MBCT-TiF), as an adapted programme for graduates of MBCT and Mindfulness-Based Stress Reduction (MBSR). MBCT-TiF sits within a global mental health approach, which aims to help shift a wider distribution of the population towards mental well-being and away from mental ill health using a...

A Validation Study of the Mindfulness-Based Interventions Teaching Assessment Criteria for Assessing Mindfulness-Based Intervention Teacher Skill: Inter-Rater Reliability and Predictive Validity.

Global Advances in Integrative Medicine and Health 2024 Frederick M Hecht, Rebecca S. Crane, Patricia J Moran et al. 2 citations

Prior data suggests the Mindfulness-Based Interventions: (MBI) Teaching Assessment Criteria (MBI:TAC) has good inter-rater reliability, but many raters knew teacher experience level. We sought to further evaluate the MBI-TAC's inter-rater reliability and obtain preliminary data on predictive validity. We videorecorded 21 MBSR teachers from academic and community settings. We trained 19...

The effect of universal school-based mindfulness on anhedonia and emotional distress and its underlying mechanisms: A cluster randomised controlled trial via experience sampling in secondary schools

Behaviour Research and Therapy September 19, 2023 Liesbeth Bogaert, Katleen van der Gucht, Peter Kuppens et al. 30 citations

This cluster randomised controlled trial examined the effectiveness of universal school-based mindfulness training (MT; vs. passive control) to lower anhedonia and emotional distress among mid-adolescents (15–18 years). It further examined three potential mechanisms: dampening of positive emotions, non-acceptance/suppression of negative emotions, and perceived social pressure not to...

Do Adolescents Like School-Based Mindfulness Training? Predictors of Mindfulness Practice and Responsiveness in the MYRIAD Trial

Journal of the American Academy of Child and Adolescent Psychiatry May 1, 2023 Jesus Montero-Marin, Verena Hinze, Catherine Crane et al.

Objective We explored what predicts secondary school students’ mindfulness practice and responsiveness to universal school-based mindfulness training (SBMT), and how students experience SBMT. Method A mixed-methods design was used. Participants were 4,232 students (11-13 years of age), in 43 UK secondary schools, who received universal SBMT (ie, “.b” program), within the MYRIAD trial...

Mindfulness Training Changes Brain Dynamics During Depressive Rumination: A Randomized Controlled Trial.

Biological Psychiatry February 1, 2023 Anne Maj van der Velden, Jacqueline Scholl, Else-Marie Elmholdt et al.

Depression is a leading cause of disability worldwide and its prevalence is on the rise. One of the most debilitating aspects of depression is the dominance and persistence of depressive rumination, a state of mind that is linked to onset and recurrence of depression. Mindfulness meditation trains adaptive attention regulation and present-moment embodied awareness, skills that may be...

The State- and Trait-Level Effects and Candidate Mechanisms of Four Mindfulness-Based Cognitive Therapy (MBCT) Practices: Two Exploratory Studies.

Mindfulness 2023 Shannon Maloney, Christina Surawy, Maryanne Martin et al. 9 citations

The primary aim was to explore state- and trait-level effects and candidate mechanisms of four Mindfulness-Based Cognitive Therapy (MBCT) practices. One hundred sixty adults self-selected from the general population were randomized to one of four mindfulness practices: body scan, mindful movement, breath and body, and befriending. Study 1 explored state-level self-compassion, mindfulness,...

DOI: 10.1007/s12671-023-02193-6 (opens in new tab) Full text (opens in new tab) Mbct Mechanisms Mindfulness practice Mindfulness-based cognitive therapy

Preventing Depression Relapse: A Qualitative Study on the Need for Additional Structured Support Following Mindfulness-Based Cognitive Therapy.

Global Advances in Integrative Medicine and Health 2023 Chelsea J Siwik, Shelley R Adler, Patricia J Moran et al. 7 citations

Mindfulness-based cognitive therapy (MBCT) is an effective group intervention for reducing rates of depression relapse. However, about one-third of graduates experience relapse within 1 year of completing the course. The current study aimed to explore the need and strategies for additional support following the MBCT course. We conducted 4 focus groups via videoconferencing, two with MBCT...

DOI: 10.1177/27536130221144247 (opens in new tab) Full text (opens in new tab) Depression relapse Maintenance program Mindfulness-based cognitive therapy

The Reliability of Rating via Audio-Recording Using the Mindfulness-Based Interventions: Teaching Assessment Criteria.

Global Advances in Integrative Medicine and Health 2023 Erin Floyd, Shelley R Adler, Rebecca S. Crane et al.

The Mindfulness-Based Interventions: Teaching Assessment Criteria (MBI:TAC) is an important tool for assessing teacher skill and aspects of the fidelity of mindfulness-based interventions, but prior research on and implementation of the MBI:TAC has used video recordings, which can be difficult to obtain, share for assessments, and which increase privacy concerns for participants. Audio-only...