Depression-like behavior is closely associated with neuroinflammation. Lipopolysaccharide (LPS) can activate N-methyl-d-aspartate receptors and induce cellular pyroptosis and neuroinflammation, thereby triggering depression-like behavior in animals. The ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) exerts significant antidepressant-like effects without the adverse effects associated with...
Mindfulness can play a critical role in promoting and protecting mental wellbeing among elite athletes. However, mechanisms of change are needed to provide theoretical insight when designing mindfulness-based programs in this population. The purpose of this study was to explore how mindfulness predicts mental wellbeing through the attitudes of gratitude (toward pleasant moments) and...
This research explores the potential of clothing as a medium for enhancing mindfulness experiences, focusing on the Mysa shirt, a product being developed by the newly founded start-up Touchwaves BV, which integrates haptic technology for breath guidance. Through a user-centered design (UCD) approach, the study focused on the Mysa shirt’s redesign and its use during mindfulness practices. From...
ABSTRACT Psychedelic drugs like lysergic acid diethylamide (LSD) and psilocybin have emerged as potentially transformative therapeutics for many neuropsychiatric diseases, including depression, anxiety, post-traumatic stress disorder, migraine, and cluster headaches. LSD and psilocybin exert their psychedelic effects via activation of the 5-hydroxytryptamine 2A receptor (HTR2A). Here we provide...
Background Randomised controlled trials (RCTs) of psilocybin have reported large antidepressant effects in adults with major depressive disorder and treatment-resistant depression (TRD). Given psilocybin's psychedelic effects, all published studies have included psychological support. These effects depend on serotonin 2A (5-HT2A) receptor activation, which can be blocked by 5-HT2A receptor...
Research SquareJune 30, 2023Bin Ling, Yun Zhu, Zelin Yan et al.
preprint
Background: ： The study was designed to investigate effects of single intravenous injection of esketamine on the incidence of postpartum depression (PPD) after labor analgesia and explore the potential mechanisms. Methods: ： A total of 120 women who underwent labor analgesia by epidural analgesia pump were enrolled and divided into two groups randomly. Esketamine at a dose of 0.2 mg/kg was...
Purpose: Investigating the changes of regional homogeneity (ReHo) values and both static and dynamic functional connectivity (FC) before and after Traditional Chinese Manual Therapy (Tuina) in patients with lumbar disk herniation (LDH) through resting-state functional magnetic resonance imaging (RS-fMRI). Based on this, we observe the effect of Tuina on the above abnormal changes. Methods:...
Background: To evaluate the effect of pre-administration of esketamine intraoperatively on the occurrence of postpartum depression after cesarean section under combined spinal-epidural anesthesia. Methods: A total of 120 women aged 24 to 36 years undergoing cesarean section by spinal-epidural anesthesia with American Society of Anesthesiologists physical status II were enrolled. According to...
Repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) has been shown to reduce cravings in heroin-dependent (HD) individuals, but the mechanisms underlying the anti-craving effects of rTMS are unknown. Abnormalities in the default mode network (DMN) are known to be consistent findings in HD individuals and are involved in cravings. We assessed...
This paper reviews the underlying evidence for various aspects of the convergence mechanism of mindfulness intervention in attention deficit hyperactivity disorder (ADHD). There may be compatibility among various ADHD remission models and the therapeutic mechanism of mindfulness intervention in ADHD may be mainly via the convergence mechanism. However, neuroimaging-based analysis of the...
Background Trauma experience increases the risk of suicidal ideation, but little is known about potentially psychological mechanisms underlying this relationship. This study aims to examine the relationship between coronavirus disease 2019 (COVID-19)-related traumatic event (CTE) exposure and suicidal ideation among hospital workers, and identify mediating roles of sleep disturbances in this...
Sage OpenApril 1, 2021Chu Wang, Jiayao Xu, Mufan Wang et al.7 citations
Nightmares influence the mental health of university students, but the prevalence of nightmare and nightmare disorder requires additional documentation. The data of detailed nightmare experience of nightmare disorder and related depressive mood in this population are also scarce. First, a total of 1,451 students in a comprehensive Chinese university were invited to report their nightmare...
Nightmares are prevalent in psychiatric disorders, and personality disorder features might be associated with nightmare experience, especially in nightmare disorder patients. The authors invited 219 healthy volunteers and 118 nightmare disorder patients to undergo tests of the Nightmare Experience Questionnaire (NEQ), the Parker Personality Measure (PERM), and the Plutchik-van Praag Depression...
HighlightsSusceptible mice showed depressive‐like behaviors upon chronic social defeat stress.Plasma corticosterone concentration might predict susceptibility to chronic stress.Abnormal glucocorticoid receptor expression was associated with susceptibility.Ketamine exerted antidepressant effect via normalizing HPA axis response. &NA; Chronic stress is an important factor for depression. Most...
Background: Highly hypnotizable individuals have impaired executive function, elevated motor impulsivity and increased emotional sensitivity, which are sometimes found in bipolar disorder patients. It is then reasonable to assume that certain aspects of hypnotic susceptibility differ with the types of bipolar disorder. Methods: The Stanford Hypnotic Susceptibility Scale: Form C (SHSS:C) test,...
Nightmares are typically extended, elaborate dream narratives, and usually occur during rapid eye movement period of sleep.Nightmare experience is accompanied by the disturbed affect culminating in arousal, which usually involves an individual's efforts to avoid threats to survival, security, or physical integrity, but often results in awakening with rapid orientation and alertness...
The purpose of the current study was to explore the cerebral areas involved in nightmare disorder. Fifteen nightmare disorder patients and 15 healthy volunteers were invited to undergo resting-state functional magnetic resonance imaging and to complete the Nightmare Experience Questionnaire. The nightmare disorder patients scored higher on the Physical Effect and Horrible Stimulation scales,...
September 30, 2014Wanzhen Chen, You Xu, Ming Zhu et al.
Background: Nightmare experience is associated with a broad spectrum of psychopathology, however, there lacks a structure-validated questionnaire to measure the effects of nightmare contents on the physical, psychological and behavioral aspects. Methods: Based on the clinical manifestation and previous documentation, we have designed a matrix of 95 items to measure the nightmare contents, plus...