Medicine
June 26, 2026
Ruixue Liu, Chunxiao Liu, Chunhui Li et al.
Dextromethorphan-bupropion, a novel oral N-methyl-D-aspartate receptor antagonist approved by the Food and Drug Administration in August 2022, launched in the United States in October 2022 for major depressive disorder. We aimed to detect and characterize the adverse events (AEs) of dextromethorphan-bupropion using the FDA adverse event reporting system from the 4th quarter of 2022 to the 4th...
Medicine
May 1, 2026
Hai-Lin Hu, Qi-Zhou Huang, Ping-Xia Xie
Esketamine, the S-enantiomer of ketamine, has emerged as a rapid-acting antidepressant with unique mechanisms. This narrative review synthesizes current evidence on its clinical applications, safety, and regulatory status based on peer-reviewed literature published between January 2000 and March 2024, searched in PubMed, Web of Science, and the Cochrane Library. Esketamine exerts its effects...
Medicine
April 3, 2026
Xiaoqian Liu, Hui Chen, Yuna Cheng et al.
Non-small cell lung cancer (NSCLC) patients undergoing surgery and adjuvant chemotherapy often experience debilitating physical and psychological symptoms, including cancer-related fatigue, anxiety, and depression. Mindfulness-based stress reduction (MBSR) has emerged as a complementary intervention to alleviate these burdens and enhance quality of life, but evidence in NSCLC populations...
Medicine
March 6, 2026
Hongfei Xiong, Yingxue Xu, Jiayi Liu et al.
This study demonstrates the efficacy of single-dose esketamine regimens, administered orally (ED95: 8.2125 mg/kg; 95% CI: 7.4250-8.4597 mg/kg) and intranasally (ED95: 2.1770 mg/kg; 95% CI: 2.0952-2.1958 mg/kg), in mitigating preoperative anxiety within a pediatric population. These findings highlight the safety and efficacy of esketamine for this patient group.
Medicine
November 21, 2025
Sanjana T Philip, Jayaram Thimmapuram, Kapil Thakur et al.
Chronic stress disrupts the neuroendocrine system, leading to imbalances in neurotransmitters and stress hormones such as oxytocin, β endorphins and cortisol, contributing to mood disorders and poor emotional regulation. Complementary and alternative practices like meditation have shown promising results in stress regulation and mood elevation. Heartfulness (HFN) meditation, rooted in yogic...
Medicine
July 4, 2025
İrem Ates, Esra Laloglu, Salih Kara et al.
2 citations
This study compared the effects of ketamine and dexmedetomidine (Dex) on inflammation and pain in liver resection surgery. Forty-five American Society of Anesthesiologists class III patients aged 18 to 65 scheduled for liver resection surgery were randomized into 3 equal groups. The ketamine group received an intravenous ketamine bolus (0.5 mg/kg) during anesthesia induction and continuous...
Medicine
May 30, 2025
Zuoju Zhang, Yanhong Dong, Yuxin Sun
2 citations
The prevention and management of cerebrovascular diseases, particularly cerebral infarction - the most prevalent type of cerebrovascular disease - pose significant challenges, severely affecting patients' physical and mental health. Mindfulness-based cognitive therapy (MBCT) has been shown to be effective in treating various mental and chronic conditions. However, there is limited evidence on...
Medicine
May 9, 2025
Lucas Bittar de Morais, Guilherme Requião Radel-Neto, Victor Alexandre Dos Santos Valsecchi et al.
5 citations
The objective of this article is to clinically compare the inducing drugs ketamine and etomidate during the orotracheal intubation procedure in critically ill patients, aiming to reduce early mortality and other important complications involved in this act. This study is compliant to the PRISMA guidelines for systematic review and meta-analysis. A sensitive search was conducted using the...
Medicine
May 2, 2025
Xiaobo Bi, Junchao Dai, Jin Li
8 citations
This study aimed to investigate the effects of a single intravenous injection of esketamine during general anesthesia on postoperative anxiety and depression in patients with thyroid cancer. In this randomized, double-blind, placebo-controlled, parallel-group trial, eighty female patients with thyroid cancer were scheduled to undergo surgery under general anesthesia. The patients were randomly...
Medicine
March 21, 2025
Lichun Xu, Aixuan Guan, Yuxin Huang
5 citations
To determine whether online mindfulness-based interventions (MBIs) help improve the physical and mental health of cancer patients, we conducted a systematic review and meta-analysis of relevant randomized controlled trials (RCTs). We searched PubMed, Web of Science, Scopus, Embase, Cochrane, Medline, and CINAHL databases for RCTs published up to April 31, 2023. Two reviewers selected and...
Medicine
February 28, 2025
Yannan Ouyang, Juan Li
8 citations
The efficacy of esketamine nasal spray for treatment-resistant depression remains controversial. This systematic review and meta-analysis was conducted to explore the influence of esketamine nasal spray on treatment efficacy for treatment-resistant depression. We conducted a comprehensive search across multiple databases, including PubMed, EMbase, Web of Science, EBSCO, and Cochrane library...
Medicine
November 1, 2024
Xiangqian Wan, Ming Li, Xiantao Li et al.
8 citations
The aim of this randomized, double-blind placebo-controlled clinical trial was to study the effects of subclinical doses of esketamine on postpartum depression and pain following elective cesarean sections. This randomized, double-blind placebo-controlled trial included 150 pregnant women undergoing elective cesarean sections. After umbilical cord clamping, participants received either...
Medicine
September 6, 2024
Yaqing Chen, Hangye Gu, Wenwei Li et al.
5 citations
Mining and updating the post-marketing safety signals of esketamine nasal spray for better identification of adverse drug event (ADE) signals and medication monitoring during clinical use to ensure patient medication safety. Downloading data from the US Food and Drug Administration Adverse Event Reporting System from Q1 2019 to Q2 2023, the reporting odds ratio, proportional reporting ratio,...
Medicine
June 7, 2024
Fan Xu, Jiquan Zhang, Shaoju Xie et al.
13 citations
Mindfulness-Based Cancer Recovery (MBCR) program is a group course training for cancer patients that combines cancer knowledge and psychological knowledge, emphasizing focusing on the psychosomatic symptoms of cancer patients. Currently, the application value of Mindfulness-Based Cancer Recovery in improving psychosomatic health of cancer patients has been confirmed, however, its intervention...
Medicine
September 15, 2023
Junye Yu, Mingyue Han, Fengru Miao et al.
26 citations
Mindfulness-based stress reduction (MBSR) has been suggested as an effective mind-body approach for relieving stress in patients with chronic diseases. As of yet, there is no conclusive research on MBSR's role in reducing affective disorders among cancer patients. A systematic review and meta-analysis was conducted to determine whether MBSR has an impact on loneliness, anxiety, and depression...
Medicine
October 14, 2022
Minkyu Sung, Eugene Koh, Yunjeong Kang et al.
4 citations
Aging accelerates during midlife. Researches have shown the health benefits of mind-body intervention (MBI). However, whether MBI is involved with aging process has not been well understood. In this study, we approach to examine the relations of MBI with this process by investigating an aging marker of the peripheral blood, blood chemistry, and self-report questionnaires. A quasi-experimental...
Medicine
January 7, 2022
Yu Chen, Renying Wang, Jie Yu et al.
Abstract Background: Survivors of intensive care unit (ICU) transfer to the common ward are often accompanied by psychological distress, negative emotions, fatigue, and sleep disturbances that affect recovery. Mindfulness-based stress reduction (MBSR) has achieved reliable results in improving physical and mental health. However, no clinical study has been conducted to evaluate the effects of...
Medicine
July 23, 2021
A. Włodarczyk, Wiesław Jerzy Cubała, Maria Gałuszko‐węgielnik et al.
23 citations
Abstract There is evidence for ketamine use in treatment-resistant depression (TRD). Several safety and tolerability concerns arise regarding adverse drug reactions and specific subpopulations. This paper aims to investigate the relationship between dissociative and psychometric measures in course of intravenous ketamine treatment in TRD inpatients with major depressive disorder and bipolar...
Medicine
June 11, 2021
Jens Knud Larsen
In view of the renewed interest in psychedelics in psychiatry it is timely to analyze psychedelic treatment in historical cohorts. Recently the therapeutic efficacy of psychedelics has been linked to the so-called phenomenon of "connectedness." The aim of the present study was to explore whether long-lasting personality changes were observed in any of the 151 Danish psychiatric patients who...
Medicine
July 2, 2020
Brendan Le Daré, Thomas Gicquel, Alain Baert et al.
11 citations
Abstract Rationale: Lysergic acid diethylamide (LSD) is a highly potent psychedelic drug derived from ergot alkaloids. The available literature data derived from controlled studies or usage in a medical setting seem reassuring; however the literature contains very rare cases of fatal self-inflicted injuries associated with LSD exposure. The behavioral disorder that created the conditions...
Medicine
December 1, 2019
Antoine Berar, Jean-Sébastien Allain, Sophie Allard et al.
Abstract Rationale: 3-Methoxyphencyclidine (3-MeO-PCP) is a new psychoactive substance derived from phencyclidine. Although it can lead to severe intoxications, the main manifestations and optimal management have not been well characterized. Here, we report 2 cases of 3-MeO-PCP intoxication in the same patient, and summarize the manifestations of this intoxication reported in literature....
Medicine
May 1, 2019
Seung-ho Lee, S. Hwang, Do‐hyung Kang et al.
Background: Hypertension and type 2 diabetes are chronic diseases, which generally require lifetime care. Meditation and yoga can be complementary to pharmacological therapies according to the scientific evidences so far. Brain education-based meditation (BEM) is a technique, which has been known to change brain structure, psychology, and physiology of healthy adult participants. This...
Medicine
September 1, 2018
Fernanda S. Correia-Melo, Gustavo C. Leal, Michelle S. Carvalho et al.
61 citations
INTRODUCTION: The use of ketamine as an option in the treatment of depressive disorder is growing rapidly, supported by numerous clinical trials attesting its efficacy and safety. Esketamine, the S (+) enantiomer of ketamine, is the most widely used form in the anesthetic environment in some countries, and new studies have shown that it may also be effective in depression and with better...
Medicine
January 31, 2018
Evangelia Liakoni, Chris Yates, Alison M. Dines et al.
38 citations
The aim of the study was to compare self-reported and analytically confirmed substance use in cases of acute recreational drug toxicity.We performed a retrospective analysis of emergency department presentations of acute recreational drug toxicity over 2 years (October 2013 to September 2015) within the European Drug Emergencies Network Plus project.Among the 10,956 cases of acute recreational...