Molecular PsychiatrySeptember 19, 2026Dijia Wang, Junnan Xu, Zhaoran Wang et al.
Hallucinations are a core feature of several psychiatric disorders, but the circuit mechanisms that separate perception from behavioral output remain poorly defined. Here, we combined an auditory discrimination task with AI-based pose analysis to quantify S-ketamine-induced false auditory threat responses and behavioral disorganization in mice. Control assays, including sucrose preference, loss...
NeuropharmacologySeptember 18, 2026Yuanlong Li, Xiangyun Dai, Junmei Hu et al.
Ketamine abuse is associated with persistent cognitive deficits and neurotoxicity, though the underlying mechanisms remain incompletely understood. While mitochondrial dysfunction and ferroptosis have been separately implicated, their causal relationship and the key molecular link in ketamine-induced hippocampal damage are unclear. Using a mouse model of ketamine-induced cognitive impairment...
BMC PsychologyJuly 23, 2025Pei Liu, Buddahavamsa Yang Li, Juan Liu et al.1 citation
Psychosocial interventions for adolescents with nonsuicidal self-injury (NSSI) still needs investigation. This study aims to explore the feasibility and preliminary efficacy of twelve weeks of loving-kindness meditation (mettā) and mindfulness of breathing (ānāpānasati) for adolescents with NSSI and their parents. This was a prospective, quasi-experimental, mixed-method pilot study with no...
The available therapeutic options for post-stroke depression patients are limited. Although SSRIs are the most commonly prescribed antidepressants, their slow onset of action and the higher risk of adverse effects or contraindications have led to an urgent need to develop fast-acting and highly specific antidepressants tailored to the needs of PSD patients. Therefore, ketamine has drawn...
Aims/Background To explore the effect of the preoperative administration of esketamine on stress indices in paediatric patients undergoing bronchoalveolar lavage (BAL) under general anaesthesia. Methods A retrospective cohort study was conducted to collect clinical data from children undergoing BAL under general anaesthesia in Tianjin Hospital of Tianjin University between February 2021 and...
PsychophysiologyJune 1, 2025Yanfen Zhen, Pei Liu, Lin Jiang et al.2 citations
Nonsuicidal self-injury (NSSI) is a recurring behavior most prevalent among adolescents in which one intentionally harms one's tissues and organs without the intent of death, which has a complex pathophysiology and lacks established interventions. As NSSI has been linked to deficits in cognitive control, mindfulness training that enhances this process may be beneficial. In this study, using...
This study evaluated changes in the white matter of the brain and psychological health variables, resulting from a neuroscience-based mindfulness intervention, the Training for Awareness, Resilience, and Action (TARA), in a population of healthy adolescents. A total of 100 healthy adolescents (57 female, age ranges 14-18 years) were randomized into the 12-week TARA intervention or a...
With the increase in the incidence of malignant tumors year by year, the number of patients is also increasing. While drug treatment for cancer patients, we have to pay attention to the psychological problems that may occur during this period. In recent years, “mindfulness” has gradually entered the clinical nursing practice of malignant tumor patients as a self-regulation method. This article...
Background Trauma experience increases the risk of suicidal ideation, but little is known about potentially psychological mechanisms underlying this relationship. This study aims to examine the relationship between coronavirus disease 2019 (COVID-19)-related traumatic event (CTE) exposure and suicidal ideation among hospital workers, and identify mediating roles of sleep disturbances in this...
The increasing prevalence of sleep disorders among university students should be taken seriously. Group counseling involving a mindfulness-based strategy may help prevent students from developing insomnia and subsequent mental health disorders. This study aimed to evaluate the ameliorating effects of a mindfulness-based group intervention on sleep problems and emotional symptoms in university...