Default mode network mechanisms of repeated transcranial magnetic stimulation in heroin addiction.
Long Jin, Menghui Yuan, Wei Zhang, Lei Wang, Jiajie Chen, Fan Wang, Jia Zhu, Tao Liu, Yixin Wei, Yunbo Li, Wei Wang, Qiang Li, Longxiao Wei
Brain Imaging and Behavior February 2023 DOI: 10.1007/s11682-022-00741-7 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Self-controlled study Peer reviewed |
|---|---|
| Sample size | 30 |
| Population | Heroin-dependent individuals, with 30 demographically matched healthy controls |
| Intervention | Repetitive transcranial magnetic stimulation (rTMS) |
| Dose | 10-Hz rTMS |
| Duration | 7-session during a week |
| Topics | Addiction Default mode network |
| Keywords | Heroin |
| Key points | Craving and withdrawal symptom scores decreased significantly in heroin-dependent individuals after a week of 10-Hz rTMS. Coupling between the left inferior parietal lobe and the left middle frontal gyrus decreased, and this change was positively correlated with changes in drug-cue-induced cravings. The authors argue that rTMS may modulate default mode network and executive control network coupling, and that the left inferior parietal lobe-left middle frontal gyrus change may be mechanistically involved in reducing cue-induced craving. |
Abstract
Repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) has been shown to reduce cravings in heroin-dependent (HD) individuals, but the mechanisms underlying the anti-craving effects of rTMS are unknown. Abnormalities in the default mode network (DMN) are known to be consistent findings in HD individuals and are involved in cravings. We assessed the effect of rTMS on DMN activity and its relationship to the treatment response. Thirty HD individuals were included in this self-controlled study, and all HD participants received 10-Hz rTMS 7-session during a week. Data for cravings and withdrawal symptoms and resting-state functional magnetic resonance imaging data were collected before and after rTMS treatment. Thirty demographically matched healthy individuals who did not receive rTMS were included as controls. We focused on changes in coupling seeded from the medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and bilateral inferior parietal lobe (IPL), which are the core regions of the DMN. The craving and withdrawal symptom score of HD individuals decreased significantly after rTMS treatment. The left IPL-left middle frontal gyrus coupling and the left IPL-right inferior occipital gyrus coupling decreased significantly, and the changes in the left IPL-left middle frontal gyrus coupling were positively correlated with changes in drug-cue induced cravings. rTMS could modulate the coupling between the DMN and executive control network (ECN). Alterations of the left IPL-left middle frontal gyrus coupling may play an important mechanistic role in reducing drug cue-induced cravings.
Citations in the library
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