Elise Fellows

2 papers in the library · 88 citations · publishing 2023

Papers

Sort Most recent Most cited

Psilocybin for treatment-resistant depression without psychedelic effects: study protocol for a 4-week, double-blind, proof-of-concept randomised controlled trial

BJPsych Open July 1, 2023 Muhammad Ishrat Husain, Nicole Ledwos, Elise Fellows et al. 41 citations

Background Randomised controlled trials (RCTs) of psilocybin have reported large antidepressant effects in adults with major depressive disorder and treatment-resistant depression (TRD). Given psilocybin's psychedelic effects, all published studies have included psychological support. These effects depend on serotonin 2A (5-HT2A) receptor activation, which can be blocked by 5-HT2A receptor...

DOI: 10.1192/bjo.2023.535 Full text Treatment-resistant depression Psilocybin Tolerability Risperidone +6

Serotonergic psychedelics for depression: What do we know about neurobiological mechanisms of action?

Frontiers in Psychiatry February 10, 2023 Muhammad Ishrat Husain, Nicole Ledwos, Elise Fellows et al. 47 citations

Introduction Current treatment options for major depressive disorder (MDD) have limited efficacy and are associated with adverse effects. Recent studies investigating the antidepressant effect of serotonergic psychedelics—also known as classic psychedelics—have promising preliminary results with large effect sizes. In this context, we conducted a review of the putative neurobiological...

DOI: 10.3389/fpsyt.2022.1076459 LSD Ayahuasca Psilocybin Psychedelics hallucinogens +6