Archives of General Psychiatry
March 1, 1960
Arthur L. Chandler
77 citations
Our use of drug-facilitated psychotherapy has been to aid repressed material to become conscious and to increase insight. Any method or tool which facilitates these processes has the possibility of being a valuable psychotherapeutic tool. Certain drugs on which we have done research, such as mescaline, ALD-52, ibogaine, psilocybin, Ditran (N-ethyl-3-piperidyl cyclopentylphenyl glycolate HC1),...
Archives of General Psychiatry
November 1, 1959
H. Aronson
32 citations
Introduction Various reports1,14have shown that the subjective sense of time can be considerably altered through changes in the external circumstances under which the judgment is made. Somewhat less is known of the influence of the subject’s physical state on his ability to estimate time. This lack may be at least partially due to the fact that most conditions, such as fever or delirium, which...
Journal of Pharmacy and Pharmacology
September 1, 1959
G Maffii
58 citations
Abstract The secondary conditioned response has been studied in rats in an experimental avoidance situation. The activity of seventeen drugs has been tested upon the secondary conditioned response developed on a stable basis after an appropriate period of training. Chlorpromazine, promazine, reserpine and morphine block the secondary avoidance conditioned response as well as the usual avoidance...
Archives of Neurology And Psychiatry
March 1, 1959
Elliot D. Luby
920 citations
Introduction The production of model psychoses has been employed as a technique for testing hypotheses relevant to the causes, correlates, and treatment of schizophrenia since 1921, when De Jong demonstrated experimental catatonia by giving bulbocapnine to animals.5This method of study has received considerable impetus with the discovery of the hallucinogenic properties of lysergic acid...
Journal of Mental Science
October 1, 1958
Frances R. Ames
184 citations
This paper describes an inquiry into the effects of giving oral doses of the narcotic drug variously known as hashish, marihuana and, in South Africa, dagga. The drug is a preparation from the plant Cannabis sativa whose narcotic effect has been known for centuries. The writer's interest in it was inspired by the work in recent years on the mental disturbances produced by the active principles...
Experimental Biology and Medicine
1958
E. B. Sigg, G. Caprio, J. A. Schneider
78 citations
(1) Reserpine antagonizes the analgesia in mice induced by morphine, meperidine and codeine. (2) Five-hydroxytryptophane, 5-hydroxytryptamine, tryptamine, amphetamine, mescaline and epinephrine prolong and enhance morphine analgesia whereas iproniazid and choline-p-tolyl-ether fail to do so. (3) Possible mechanisms involved in the synergistic action of amines and the antagonistic action of...
British Journal of Pharmacology and Chemotherapy
September 1, 1957
William A. Krivoy
23 citations
Lysergic acid diethylamide (LSD) potentiated the response of guinea‐pig ileum to substance P but not to histamine. It also inhibited the disappearance of substance P when incubated with guinea‐pig brain extract but not when incubated with chymotrypsin. Eserine, morphine, mescaline, chlorpromazine, ergometrine, strychnine and 2 bromo‐LSD did not have this effect. Oxytocin was not destroyed by...
American Journal of Psychiatry
April 1, 1957
Harry H. Pennes, Paul H. Hoch
89 citations
Harmine, Win-2299, and Nalline in single dosage produce many new mental effects in schizophrenics grossly similar to those elicited by mescaline and LSD. Many of the same effects are reported in normals after harmine and Nalline (other workers). unlike mescaline and LSD at usual dosage levels, the present psychotomimetics regularly produce drowsiness and sleep along with the aberrant mental...
A M A Archives of Neurology & Psychiatry
June 1, 1956
Nicholas A. Bercel
35 citations
INTRODUCTION Experimental psychosis has a long history. It might have started with the administration of Cannabis indica boiling in wine to the ancient Hun warriors, resulting in mental obfuscation, as they were prepared for surgery because of wounds sustained in battle. Scientific experimental psychiatry began toward the end of the last century, in the Kraepelinian era—when the organic theory...
Archives of Neurology And Psychiatry
1956
Edward V. Evarts
52 citations
INTRODUCTION Bufotenine (5 -hydroxy -3 -[2- dimethyl-aminoethyl]-indole) is the N-dimethyl derivative of the vasoconstrictor substance serotonin (5-hydroxytryptamine). It was first synthesized by Wieland in 1934. Raymond-Hamet found that intravenous injection of bufotenine caused transient elevation of blood pressure and apnea, followed by tachypnea, in anesthetized dogs.* To date, however,...