Journal of Pharmacy and Pharmacology
September 1, 2002
Christian Albers, Matthias Lehr, Justus Beike et al.
7 citations
Abstract Derivatives of psilocin with ω-functionalized alkyl spacers in position 1 of the indole ring were synthesized as haptens for use in a radioimmunoassay. Whereas the psilocin analogues with a 3-aminopropyl and a 4-aminobutyl moiety at the indole nitrogen decomposed during synthesis, the analogous 3-carboxypropyl psilocin derivative proved to be stable. This compound was coupled to bovine...
Journal of Pharmacy and Pharmacology
October 2001
Mary L. Forsling, John K. Fallon, A T Kicman et al.
The aim of this investigation was to examine the effect of 3,4-methylenedioxymethamphetamine (MDMA) administration on arginine vasopressin (AVP) release. (R,S)-MDMA (40 mg) was administered to eight normally hydrated healthy male volunteers (22-32 years) and blood samples were collected up to 24 h. Plasma was assayed for AVP and cortisol by radioimmunoassays, and for MDMA and the N-demethylated...
Journal of Pharmacy and Pharmacology
October 1, 1994
J L Fitzgerald, J J Reid
Abstract: The aim of this study was to investigate the actions of methylenedioxymethamphetamine (MDMA) in several isolated cardiovascular tissues. In spontaneously beating rat atria, concentration-dependent positive chronotropic responses to MDMA and amphetamine were blocked by the neuronaluptake inhibitor desipramine (1 μm) and the β-adrenoceptor antagonist propranolol (1 μm). In atria...
Journal of Pharmacy and Pharmacology
December 1, 1985
Michael E. Trulson, Terriann Crisp, Leslie J. Henderson
Pretreatment with ascorbic acid (500 mg kg-1 i.p.) antagonized the behavioural effects of lysergic acid diethylamide (LSD) and apomorphine, but not 5-methoxy-N,N-dimethyltryptamine, in cats. The data support the hypothesis that these behavioural effects in cats are due to drug action at both 5-HT and dopamine receptors, and that the action of LSD at dopamine receptors is modulated by ascorbic...
Journal of Pharmacy and Pharmacology
September 1, 1985
T Archer, B Tandberg, L Rényi et al.
8 citations
Repeated administration of drugs that increase tryptaminergic neurotransmission antagonized the increase in latency to onset and the duration of postdecapitation convulsions (PDCs) induced by an acute 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) injection; Zimelidine (2 X 5 mg kg-1), fluoxetine (2 X 5 mg kg-1), amiflamine (2 X 2.5 mg kg-1) and alpha-ethyltryptamine (2 X 2.5 mg kg-1) administered...
Journal of Pharmacy and Pharmacology
August 1985
D Lemaire, Peyton Jacob, Alexander T. Shulgin
Four members of a new class of psychotomimetic agents have been synthesized and evaluated in man. These compounds, which incorporate a beta-methoxy group onto a beta-phenethylamine sidechain, are the first reported psychotomimetics which are structural analogues of the neurotransmitter noradrenaline. These substances are more potent than the corresponding phenethylamines (lacking a beta-methoxy...
Journal of Pharmacy and Pharmacology
September 1, 1978
Mitsutaka Nakamura, Hideaki Fukushima
25 citations
Journal Article Effect of 5, 6-dihydroxytryptamine on the head twitches induced by 5-HTP, 5-HT, mescaline and fludiazepam in mice Get access Mitsutaka Nakamura, Mitsutaka Nakamura Research and Development Centre, Pharmaceuticals Division, Sumitomo Chemical Co. Ltd., 4-2-1, Takatusukasa, Takarazuka, Hyogo, 665, Japan Correspondence: Research and Development Centre, Pharmaceuticals Division,...
Journal of Pharmacy and Pharmacology
April 1, 1978
J D Sinden, D M Atrens
J D Sinden, D M Atrens; 5-Methoxy-NN-dimethyltryptamine: differential modulation of the rewarding and aversive components of lateral hypothalamic self-stimulati
Journal of Pharmacy and Pharmacology
September 1, 1977
Joanna Maj, W Palider, A. Rawłów
17 citations
Journal Article The influence of mescaline on the flexor reflex of the hind limb of the spinal rat Get access J Maj, J Maj Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland Correspondence: Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland Search for other works by this author on: Oxford Academic Google Scholar W Palider, W Palider Institute of...
Journal of Pharmacy and Pharmacology
March 1, 1975
Liisa Ahtee
Abstract: The effect of dextromethorphan on the uptake and metabolism of 5-hydroxytryptamine (5-HT) was studied in human blood platelets and in rat brain. In the concentration of 120 nM dextromethorphan inhibited the uptake of 5-HT (1 μM) into platelets by 50%. The corresponding concentrations of imipramine and methadone under similar conditions were 22 and 590 nM, respectively....
Journal of Pharmacy and Pharmacology
1975
Alan S. Horn, Michael L. Post, Olga Kennard et al.
4 citations
Abstract The crystal and molecular structure of 2,5-dimethoxy-4-ethyl-α-methyl-phenylethylamine (DOET) has been determined by X-ray crystallography and the conformation of the side chain has been examined theoretically by the use of a potential energy calculation. There is no indication in the solid state of any intra or inter-molecular hydrogen bonding. The isopropylamine side chain is...
Journal of Pharmacy and Pharmacology
October 1, 1973
John G Sinclair
Abstract: Severe toxic reactions may occur clinically when imipramine, pethidine or dextromethorphan is administered to a patient being treated with a monoamine oxidase inhibitor (MAOI). Previous reports indicate that imipramine or pethidine produces symptoms characterized by motor restlessness, tremor, extreme hyperpyrexia and death when administered to phenelzine-pretreated rabbits. The...
Journal of Pharmacy and Pharmacology
November 1, 1970
K. Genest, Lorna J. Lowry
Abstract Microcrystallopic tests for LSD, NN-diethyltryptamine, NN-dimethyltryptamine, bufotenine, psilocin, psilocybin and STP are described. The tests are recommended in conjunction with other analytical techniques if applied for the forensic identification of hallucingens.
Journal of Pharmacy and Pharmacology
November 1, 1969
R. J. Mesley, W H Evans
14 citations
Abstract Infrared spectra of LSD and its tartrate salts, and factors affecting their reproducibility, have been investigated. Spectra corresponding to amorphous and crystalline forms of LSD base, the neutral tartrate and two forms of the hydrogen tartrate were obtained. The neutral tartrate was found to undergo conversion to the hydrogen tartrate on long standing. Comparison with spectra of...
Journal of Pharmacy and Pharmacology
1969
G F Phillips, R J Mesley
Abstract Physical characteristics are reported for a tablet form of a new hallucinogenic drug previously circulating in the USA under the name “STP”. High resolution mass, nmr, ultraviolet and infrared spectrometric evidence, which identify the extracted base as 2,5-dimethoxy-4-methylamphetamine, and its chromatographic behaviour, are compared with the experimental compound “DOM”. Polymorphic...
Journal of Pharmacy and Pharmacology
September 1, 1963
A Chodera
Abstract The effects of two lysergic acid derivatives, 2-bromlysergic acid diethylamide ‘BOL 148’ and 1-methyl-lysergic acid butanolamide ‘UML 491’ on the antidiuresis induced by 5-hydroxytryptamine ‘5-HT’ has been studied in rats given a dose of 1 mg./kg. 5-HT subcutaneously. BOL 148, 5 mg./kg., and UML 491, 2·5 mg./kg., counteracted the induced antidiuresis. By contrast, the antidiuretic...
Journal of Pharmacy and Pharmacology
September 1, 1959
G Maffii
58 citations
Abstract The secondary conditioned response has been studied in rats in an experimental avoidance situation. The activity of seventeen drugs has been tested upon the secondary conditioned response developed on a stable basis after an appropriate period of training. Chlorpromazine, promazine, reserpine and morphine block the secondary avoidance conditioned response as well as the usual avoidance...
Journal of Pharmacy and Pharmacology
September 1, 1958
G Maffii, E Soncin
8 citations
Abstract The effects of mescaline on spontaneous activity of mice placed in special cages have been studied. The typical response (stereotyped response) has been recorded and assessed in terms of percentage of animals showing the effect. Among drugs affecting the response chloropromazine shows the highest specificity. Promazine, hexobarbitone and pentobarbitone also show a definite but minor...
Journal of Pharmacy and Pharmacology
September 1, 1957
E Rothlin
64 citations
Journal Article Pharmacology of Lysergic Acid Diethylamide and Some of Its Related CompoundS Get access E Rothlin E Rothlin Professor of the University of Basle, Sonnenweg 6, Basle Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 9, Issue 1, September 1957, Pages 569–587, https://doi.org/10.1111/j.2042-7158.1957.tb12312.x...