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Journal of Pharmacy and Pharmacology

ISSN 2042-7158

11 papers in the library · 197 citations · publishing 1957-2002

Papers

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Synthesis of a psilocin hapten and a protein-hapten conjugate

Journal of Pharmacy and Pharmacology September 1, 2002 Christian Albers, Matthias Lehr, Justus Beike et al. 7 citations

Abstract Derivatives of psilocin with ω-functionalized alkyl spacers in position 1 of the indole ring were synthesized as haptens for use in a radioimmunoassay. Whereas the psilocin analogues with a 3-aminopropyl and a 4-aminobutyl moiety at the indole nitrogen decomposed during synthesis, the analogous 3-carboxypropyl psilocin derivative proved to be stable. This compound was coupled to bovine...

Effect of 5, 6-dihydroxytryptamine on the head twitches induced by 5-HTP, 5-HT, mescaline and fludiazepam in mice

Journal of Pharmacy and Pharmacology September 1, 1978 Mitsutaka Nakamura, Hideaki Fukushima 25 citations

Journal Article Effect of 5, 6-dihydroxytryptamine on the head twitches induced by 5-HTP, 5-HT, mescaline and fludiazepam in mice Get access Mitsutaka Nakamura, Mitsutaka Nakamura Research and Development Centre, Pharmaceuticals Division, Sumitomo Chemical Co. Ltd., 4-2-1, Takatusukasa, Takarazuka, Hyogo, 665, Japan Correspondence: Research and Development Centre, Pharmaceuticals Division,...

The influence of mescaline on the flexor reflex of the hind limb of the spinal rat

Journal of Pharmacy and Pharmacology September 1, 1977 Joanna Maj, W Palider, A. Rawłów 17 citations

Journal Article The influence of mescaline on the flexor reflex of the hind limb of the spinal rat Get access J Maj, J Maj Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland Correspondence: Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland Search for other works by this author on: Oxford Academic Google Scholar W Palider, W Palider Institute of...

A crystallographic and theoretical study of the conformation of DOET and its significance for the hallucinogenic amphetamines

Journal of Pharmacy and Pharmacology 1975 Alan S. Horn, Michael L. Post, Olga Kennard et al. 4 citations

Abstract The crystal and molecular structure of 2,5-dimethoxy-4-ethyl-α-methyl-phenylethylamine (DOET) has been determined by X-ray crystallography and the conformation of the side chain has been examined theoretically by the use of a potential energy calculation. There is no indication in the solid state of any intra or inter-molecular hydrogen bonding. The isopropylamine side chain is...

Microcrystalloptic tests for lysergic acid diethylamide and other hallucinogens

Journal of Pharmacy and Pharmacology November 1, 1970 K. Genest, Lorna J. Lowry

Abstract Microcrystallopic tests for LSD, NN-diethyltryptamine, NN-dimethyltryptamine, bufotenine, psilocin, psilocybin and STP are described. The tests are recommended in conjunction with other analytical techniques if applied for the forensic identification of hallucingens.

Infrared identification of lysergide (LSD)

Journal of Pharmacy and Pharmacology November 1, 1969 R. J. Mesley, W H Evans 14 citations

Abstract Infrared spectra of LSD and its tartrate salts, and factors affecting their reproducibility, have been investigated. Spectra corresponding to amorphous and crystalline forms of LSD base, the neutral tartrate and two forms of the hydrogen tartrate were obtained. The neutral tartrate was found to undergo conversion to the hydrogen tartrate on long standing. Comparison with spectra of...

Examination of the hallucinogen 2,5-dimethoxy-4-methylamphetamine

Journal of Pharmacy and Pharmacology 1969 G F Phillips, R J Mesley

Abstract Physical characteristics are reported for a tablet form of a new hallucinogenic drug previously circulating in the USA under the name “STP”. High resolution mass, nmr, ultraviolet and infrared spectrometric evidence, which identify the extracted base as 2,5-dimethoxy-4-methylamphetamine, and its chromatographic behaviour, are compared with the experimental compound “DOM”. Polymorphic...

Blockade of 5-Hydroxytryptamine Antidiuresis in Rats by 2-Bromlysergic Acid Diethylamide Tartrate and 1-Methyl-Lysergic Acid Butanolamide

Journal of Pharmacy and Pharmacology September 1, 1963 A Chodera

Abstract The effects of two lysergic acid derivatives, 2-bromlysergic acid diethylamide ‘BOL 148’ and 1-methyl-lysergic acid butanolamide ‘UML 491’ on the antidiuresis induced by 5-hydroxytryptamine ‘5-HT’ has been studied in rats given a dose of 1 mg./kg. 5-HT subcutaneously. BOL 148, 5 mg./kg., and UML 491, 2·5 mg./kg., counteracted the induced antidiuresis. By contrast, the antidiuretic...

The Secondary Conditioned Response of Rats and the Effects of Some Psychopharmacological Agents

Journal of Pharmacy and Pharmacology September 1, 1959 G Maffii 58 citations

Abstract The secondary conditioned response has been studied in rats in an experimental avoidance situation. The activity of seventeen drugs has been tested upon the secondary conditioned response developed on a stable basis after an appropriate period of training. Chlorpromazine, promazine, reserpine and morphine block the secondary avoidance conditioned response as well as the usual avoidance...

A STEREOTYPED RESPONSE INDUCED BY MESCALINE IN MICE AS A MEANS OF INVESTIGATING THE PROPERTIES OF DRUGS ACTING ON THE CNS

Journal of Pharmacy and Pharmacology September 1, 1958 G Maffii, E Soncin 8 citations

Abstract The effects of mescaline on spontaneous activity of mice placed in special cages have been studied. The typical response (stereotyped response) has been recorded and assessed in terms of percentage of animals showing the effect. Among drugs affecting the response chloropromazine shows the highest specificity. Promazine, hexobarbitone and pentobarbitone also show a definite but minor...

Pharmacology of Lysergic Acid Diethylamide and Some of Its Related CompoundS

Journal of Pharmacy and Pharmacology September 1, 1957 E Rothlin 64 citations

Journal Article Pharmacology of Lysergic Acid Diethylamide and Some of Its Related CompoundS Get access E Rothlin E Rothlin Professor of the University of Basle, Sonnenweg 6, Basle Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 9, Issue 1, September 1957, Pages 569–587, https://doi.org/10.1111/j.2042-7158.1957.tb12312.x...