Elliot D. Luby - The Consciousness Library

Study of a New Schizophrenomimetic Drug—Sernyl

Archives of Neurology And Psychiatry March 1, 1959 Elliot D. Luby 920 citations

Since 1921, researchers have induced temporary psychotic-like states in animals and humans using drugs such as bulbocapnine, mescaline, and LSD-25, aiming to test theories about schizophrenia. Some psychiatrists, like Ebaugh, argue these drug-induced pseudopsychoses differ so markedly from schizophrenia that their relevance to understanding the disorder is limited. Others, like Wikler, contend that for developing causal concepts of behavior, whether the model psychoses resemble schizophrenia is unimportant. The abstract presents this ongoing debate without resolving it.

DOI: 10.1001/archneurpsyc.1959.02340150095011 Lysergic acid diethylamide Mescaline Schizophrenia object-oriented programming Hallucinogen +8

Phencyclidine/schizophrenia: one view toward the past, the other to the future.

Schizophrenia Bulletin September 1, 2012 Edward F. Domino, Elliot D. Luby

Phencyclidine, originally developed as a general anesthetic, has also been used as a chemical model of schizophrenia and as a drug of abuse. Research on phencyclidine and its chemical derivatives, such as ketamine, has laid a foundation for understanding the neuropathology of schizophrenia, though this understanding is still in its early stages.

DOI: 10.1093/schbul/sbs011 Full text

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Study of a New Schizophrenomimetic Drug—Sernyl

Phencyclidine/schizophrenia: one view toward the past, the other to the future.