The Japanese Journal of Pharmacology
1971
B.d. Gupta, P.c. Dandiya, Mahima Gupta
78 citations
The Open Field Test situation is reported to produce autonomic nervous system reactivity determined emotional freezing and defecation (1, 2), cortical excitation determined rearing activity (3), and corpus striatum activity determined stereotyped ambulation (4, 5). Thus autonomic depressant drugs reduce emotional freezing (6), cortical excitant drugs augment rearing (7, 8), and hallucinatory...
Archives of General Psychiatry
1971
Solomon H. Snyder
30 citations
DOET (2,5-dimethoxy-4-ethylamphetamine) is a new psychotropic agent which chemically resembles mescaline and amphetamine. It is essentially the ethyl homologue of DOM (2,5-dimethoxy-4-methylamphetamine), a psychotomimetic drug widely used by hippie populations and designated "STP." DOET was administered to normal male subjects in doses ranging from 0.75 to 4 mg and contrasted with effects of a...
Proceedings of the National Academy of Sciences
September 1, 1970
Sungzong Kang, Jack Peter Green
64 citations
Stereochemical considerations and total valence electron calculations suggest congruities among the ostensibly dissimilar hallucinogenic compounds, D-lysergic acid diethylamide (LSD), indolcalkylamines, and methoxylated amphetamines. In LSD the aromatic benzene ring A and the N-6 nitrogen are essential for hallucinogenic activity; these sites may react with the receptor. The conformations of...
JAMA
September 9, 1968
Lionel Grossbard
23 citations
Acute leukemia occurred in a user of several hallucinogenic drugs (lysergic acid diethylamide [LSD], mescaline, marihuana, and amphetamines). The leukemic leukocytes of the patient contained a Ph1-like chromosome; lymphocytes transformed with phytohemagglutinin did not show chromosome breaks. A Ph1-like chromosome has only rarely been reported in either acute leukemia or in cultured lymphocytes...
American Journal of Psychiatry
September 1, 1968
Solomon H. Snyder, Louis A. Faillace, Herbert Weingartner
77 citations
DOM, a hallucinogen related to mescaline and amphetamine and designated "STP" by hippies, along with DOET, the ethyl homologue of DOM, were given in small doses to normal subjects in a double-blind study. Both drugs increased self-awareness and produced mild euphoria but no hallucinogenic or psychotomimetic effects. The two drugs "freed up" subjects' word associations without impairing memory...
Journal of Psychedelic Drugs
April 1, 1968
Janet Sherwood, Myron J. Stolaroff, Willis W. Harman
24 citations
Abstract The authors, by the simultaneous administration of massive doses of lysergic acid diethylamide (LSD) and mescaline, tried to produce a unique experience for the patient which is to be so profound and impressive that it changes the patient's own evaluation of his past life experiences and consequently may lead him to establish new values and a more realistic frame of reference than had...
Science
November 3, 1967
Solomon H. Snyder, Louis A. Faillace, Leo E. Hollister
146 citations
We have assessed the effects in normal control volunteers of 2,5-dimethoxy-4-methyl-amphetamine, the chemical present in the hallucinogenic drug STP, in two independent trials. In low doses, this compound produces a mild euphoria. Doses greater than 3 milligrams may cause pronounced hallucinogenic effects lasting about 8 hours and similar to those produced by hallucinogenic doses of lysergic...
Archives of General Psychiatry
September 1, 1966
Stephen Szára
33 citations
SIMPLE INDOLE derivatives like the alkylated tryptamines, N,N-dimethyltryptamine (DMT) and N,N-diethyltryptamine (DET), produce psychotogenic-like symptoms similar to lysergic acid diethyemide (LSD) and mescaline.1-4 One of the important metabolic pathways of DET has been shown to be by 6-hydroxylation.5The known metabolic pathways of DET are summarized in Fig 1. Other investigators have...
Journal of Asthma Research
1965
Harold A. Abramson, Anabela P. Rolo
21 citations
This paper is a continuation of our experiments with LSD-25 and similar compounds that have been carried out for the last thirteen years.1 It employs the same technique described previously2 to compare these drugs on non-psychotic test subjects under suitable conditions. The conditions of the experiment are most important because under certain circumstances the experimental milieu produces so...
JAMA
March 7, 1964
Jonathan Cole, Martin M. Katz
16 citations
FOR MANY YEARS several pharmacologically similar drugs—lysergic acid diethylamide (LSD-25), psilocybin, and mescaline, among others—have been of special scientific interest. In volunteer subjects, they have been known to produce a variety of intense and unusual psychic effects. These include bizarre visual phenomena, ranging from a heightening of the apparent brightness or beauty of colored...