Molecular Psychiatry
May 29, 2026
Mickael Eskinazi, Rayan Nasserdine, Romane M Cusin et al.
Serotonergic psychedelics are increasingly investigated as treatments for affective disorders. Concerns persist regarding their potential to induce hypomania or mania, particularly in individuals with bipolar spectrum vulnerability. Whether these substances precipitate transient mood switches or contribute to persistent bipolar illness or diagnostic transition remains unclear. We conducted a...
Cygne Noir
May 27, 2026
Gautier Dassonneville
2 citations
Dans quel cadre culturel et théorique la fameuse expérimentation de mescaline par Jean-Paul Sartre s’est-elle déroulée ? En répondant à cette question, nous mettons au jour comment un modèle psychopathologique fonctionne à plein régime dans les « Notes sur la prise de mescaline » (2010 [1935]) et continue de nourrir la description eidétique de l’imagination chez Sartre, malgré la réduction...
RevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia
May 1, 2026
Mariana Silva‐Carvalho, Andreia Machado Brito-Da-Costa, Ricardo Dinis-Oliveira et al.
Psilocybin, psilocin, 5-MeO-DMT, LSD and mescaline are classical hallucinogens whose recreational use has increased over recent decades (Brito-da-Costa et al., 2021; Dinis-Oliveira et al., 2019; Holze et al., 2021; Jiang et al., 2013). However, data on their interactions with cytochrome P450 (CYP450) enzymes remain scarce, despite the potential for clinically relevant drug–drug interactions....
Natural Product Communications
April 20, 2026
Bruce K. Cassels
11 citations
Alkaloids of the Cactaceae have been studied for the last 120 years. The first half of that period provided the “classic” compounds, after which a large number of usually very similar analogs were isolated or determined with modern methods. Although some unusual synthetic approaches have been developed, their preparation is generally quite straightforward. Their biosynthesis has been studied...
Journal of Psychopharmacology
April 16, 2026
Jesse J. Norris
1 citation
Background: Little research investigates the role of rarely used drugs in criminal offending. Moreover, given research suggesting that psychedelics reduce criminal offending, more research is needed to further document connections between psychedelics and crime. Aim: This study examines the role of rarely used drugs in criminal behavior and extends previous research on psychedelics by...
Preprints.org
April 7, 2026
Luis Miguel Gallardo
preprint
Altered states of consciousness (ASC) represent a universal human capacity for accessing and transforming the subconscious mind, employed across cultures and millennia through diverse contemplative, somatic, pharmacological, ritual, and technological modalities. This comprehensive review synthesizes evidence from over 25 distinct disciplines spanning five clusters: (A) contemplative and...
Neuroscience
April 6, 2026
Fernando Minauro-Sanmiguel, Hector Vargas-Perez
Mitochondrial dysfunction is increasingly recognized as a central driver of Alzheimer's disease (AD), contributing to neuroinflammation, synaptic failure, and energy collapse.Emerging preclinical evidence suggests that classic hallucinogens, such as psilocybin, lysergic acid diethylamide (LSD), N,N-dimethyltryptamine (DMT), mescaline, may restore mitochondrial integrity by activating Serotonin...
Nature Medicine
April 1, 2026
Manesh Girn, Manoj K. Doss, Leor Roseman et al.
8 citations
Psychedelic drugs are re-emerging as promising scientific and clinical tools. However, despite a rapidly expanding literature on their therapeutic value, the neural mechanisms underlying psychedelic effects remain unclear. Resting-state functional magnetic resonance imaging studies of acute psychedelic effects, conducted independently by several research groups, have so far yielded fragmented...
Religion, Brain & Behavior
March 31, 2026
Kurt Stocker, Matthias Hartmann, Frederick S. Barrett et al.
Mystical dynamics—the notion that mystical oneness may unfold involving ego disintegration, renewal, and luminous light—has been discussed anecdotally by psychedelic researchers and therapists but has not yet been empirically examined in controlled settings. This study investigated the occurrence and dose-dependency of mystical dynamics in healthy participants after administration of...
Cambridge University Press eBooks
March 27, 2026
David Stephen Calonne
This chapter explores the many ways Mexico became central in Ginsberg’s poetic evolution. Inspired by the example of his mentor, William S. Burroughs, Ginsberg visited several archaeological sites in Mexico such as Palenque, which inspired one of his most successful early poems, “Siesta in Xbalba.” Ginsberg traveled widely throughout the country and continued the mystical quest which began with...