Intravenous injection of synthetic mescaline was used in a group of schizophrenic patients and on "normal" voluntary controls. The changes produced by mescaline in "normals" were described. In addition, the observations were made that mescaline is able to underscore in patients suffering from schizophrenia their schizophrenic symptoms or able to precipitate schizophrenic psychoses in persons...
Mescaline, cocaine, sodium amytal and benzedrine were given to 14 schizophrenic patients, and their influence upon personality functions and the electroencephalogram (EEG) was observed. Changes in the EEG were found only when definite psychological changes took place. The effects of the drugs could be classified into two types: 1) Those specific for a given drug. Psychologically these were...
This systematic review evaluates the relationship between classical psychedelic drugs (D-Lysergic acid N,N-diethylamide, psilocybin, ayahuasca/N-N-dimethyl-tryptamine, and mescaline) and the emergence of psychotic symptoms, aiming to synthesize evidence from contemporary studies (1984-2025) regarding the risk factors, prevalence, and clinical characteristics of psychosis related to psychedelic...
Surgical Neurology InternationalOctober 9, 2026Andrea Garcia-Bitar, Eduardo Jesus Castañeda, José Rafael Buenrostro-Rangel et al.
Background: Neurosurgical patients carry a high and frequently undertreated burden of psychological suffering, acute and chronic pain, and neurological deficits amenable to recovery. The resurgence of psychedelic research has produced relevant evidence in adjacent fields, but its applicability to neurosurgery has not been systematized. This review synthesizes that evidence across prevention,...
Pedro Ortiz Cabanillas (1933-2011), a Peruvian neurologist and professor at Universidad Nacional Mayor de San Marcos, spent five decades building an Sociobiological Informational Theory: a systematic account of the universe, life, and organized society built around a single, redefined concept -information- understood as a material structure exclusive to living systems. Two works anchor his...
The Plants That Remembered the Sky: Sacred Landscapes, Mythic Plants and the Human Imagination Description This work explores recurring symbolic relationships between sacred plants, cosmology, landscape, memory and transformation across multiple Indigenous traditions of the Americas. Drawing upon mythological narratives, ethnographic records, archaeological findings and comparative symbolism,...
medRxivSeptember 10, 2026Mori Krantz, Mark C. Haigney, Mary Ross Southworth et al.
preprint
Background: Several Schedule I substances have demonstrated potential benefits for refractory psychiatric conditions and addiction. Some have been legalized at the state level, while others like kratom (mitragynine) are available over-the-counter in some states and illegal in others. A recent presidential executive order directs certain federal agencies to accelerate development and facilitate...
Abstract Background Serotonin 2A receptor (5-HT2AR) agonists play a crucial role in multiple cognitive processes, namely executive functions, learning and memory. Owing partly to this, psychedelics such as lysergic acid diethylamide (LSD), psilocybin, dimethyltryptamine (DMT), mescaline and ayahuasca might be valuable adjuvants in improving memory deficits and language impairment. Thanks to...
Cette communication traite des représentations, discours et pratiques liés à l’absorption de plantes psychotropes, initialement employées dans les contextes shamaniques à travers le monde et désormais réappropriées dans le cadre d’une quête de soi dans les sociétés post-industrielles. Après un bref retour sur les circonstances socioculturelles et les raisons individuelles de ces investissements...
This thesis investigates the mescaline experience as a peculiar and radical form of phenomenological reduction. It begins by examining the constitution of the human lived world through Wittgenstein's concept of Weltbild and Merleau-Ponty's phenomenology of perception and embodiment. The argument distinguishes between a pre-predicative, perceptual “first world” and a linguistically and...