Page 15 of 97: studies 141 to 150 of 963, newest first. Back to the mescaline overview
Chemischer Informationsdienst November 27, 1984 P. Iii Jacob, Alexander T. Shulgin
AbstractDargestellt und auf ZNS‐Wirkung untersucht werden die Verbindungen (V), (VII) und (VIII).
European Journal of Drug Metabolism and Pharmacokinetics October 1, 1984 N S Shah, O D Gulati
Levels of unchanged mescaline were examined in the plasma and brain of albino Swiss-Webster mice pretreated with various doses of either clozapine or molindone. In clozapine treated mice, the mescaline levels were statistically significantly higher at 2 and 3 h with 7.5 and 15.0 mg/kg and at 1, 2 and 3 h with 30 mg/kg. Molindone at 4.0 and 8.0 mg/kg produced no significant effect; at 16.0 and...
Pharmacology, Biochemistry, and Behavior August 1, 1984 David J. Mokler, Richard H. Rech 17 citations
The effects on a fixed ratio-40 (FR-40) operant behavior of intracerebroventricular (ICV) administration of the hallucinogens lysergic acid diethylamide (LSD), 2,5-dimethoxy-4-methylamphetamine (DOM), mescaline or the non-hallucinogenic LSD-analogue lisuride were compared with intraperitoneal (IP) administration. Infusion of LSD (8.5 to 34 micrograms) into the left lateral ventricle produced a...
Journal of Medicinal Chemistry July 1, 1984 Peyton Jacob, Alexander T. Shulgin 14 citations
All possible monothio analogues of the mono-, di-, and triethoxy homologues of mescaline have been synthesized and pharmacologically evaluated in man. Modifications at the ring position para to the ethylamine chain, either with a sulfur atom, a longer alkyl chain, or both, lead to compounds of high central nervous system activity. The 4-n-propoxy and 4-n-butoxy homologues and their...
European Journal of Pharmacology December 1, 1983 Michael E. Trulson, Terriann Crisp, Leslie J. Henderson 21 citations
The characteristic behavioral effects of mescaline in cats were nearly completely blocked by pretreatment with low doses of either a specific serotonin antagonist (methysergide) or a dopamine specific antagonist (haloperidol). These blocking effects were not due to non-specific actions, since methysergide did not block the behavioral effects of apomorphine, and haloperidol did not block the...
Chemischer Informationsdienst August 30, 1983 Michal W. Majchrzak, A. Kotelko, Roman Guryn et al.
AbstractDurch Alkylierung der Piperazine und Homopiperazine (II) bzw. (IV) mit Trimethoxyphenylethylchlorid (I) erhält man die sedativ wirksamen Mescalinderivate (III) und (V).
Journal of Pharmaceutical Sciences March 1, 1983 Michal W. Majchrzak, A Kotełko, Roman Guryn et al. 5 citations
Structural juxtaposition of the 3,4,5-trimethoxyphenyl group in the same molecule with a piperazine or homopiperazine ring has been realized in a series of mescaline analogues (I-IV) as part of an investigation into the pharmacological properties of the seven-membered perhydro-1,4-diazepines (homopiperazines). The analogous six-membered piperazines were synthesized and tested as reference...
The Japanese Journal of Pharmacology 1983 Tsuneyuki Yamamoto, Naoe Tazoe, Showa Ueki et al. 2 citations
The effect of zotepine, a new neuroleptic, on head-twitch induced by L-5-hydroxytryptophan (L-5HTP), mescaline and 2,5-dimethoxy-4-methylamphetamine (DOM) in mice and rats was compared with that of known neuroleptics and the serotonin receptor blocker cyproheptadine. Among the neuroleptics tested, zotepine and halo-peridol produced potent inhibitory effects on head-twitch induced by these three...
The Japanese Journal of Pharmacology 1983 Tsuneyuki Yamamoto, Naoe Tazoe, Showa Ueki et al. 9 citations
The effect of zotepine, a new neuroleptic, on head-twitch induced by L-5-hydroxytryptophan (L-5HTP), mescaline and 2,5-dimethoxy-4-methylamphetamine (DOM) in mice and rats was compared with that of known neuroleptics and the serotonin receptor blocker cyproheptadine. Among the neuroleptics tested, zotepine and haloperidol produced potent inhibitory effects on head-twitch induced by these three...
Drug Development Research 1983 C. J. E. Niemegeers, Françis C. Colpaert, J.e. Leysen et al. 58 citations
Abstract An intravenous dose of 20.0 mg/kg of mescaline induced a reproducible head‐twitch response in rats. Drugs with very different pharmacological activities were tested for potential inhibition of this response. Among these drugs were a large number of serotonin antagonists, including several members of the recently described selective S 2 antagonists of which ketanserin (a potent vascular...