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Chemischer Informationsdienst August 21, 1979 A. M. Kadry, Y. A. Ibrahim, K. M. Ghoneim et al.
AbstractAusgehend von der Trihydroxybenzoesäure (I) wird auf dem im Formelschema angegebenen Weg das Mescalinderivat (IX) hergestellt.
Journal of Pharmaceutical Sciences July 1, 1979 Richard A Glennon, Lemont B. Kier, Alexander T. Shulgin 29 citations
The hallucinogenic (psychotomimetic) potency of 10 mescaline analogs was examined by molecular connectivity analysis. Potencies could be described by a two-term relating equation, which explained 94% of the variance in activity, on the basis of structural variation, 2,5-Dimethoxy substitution as well as the nature of the 4-position substituent played an important role in determining...
Pharmacology, Biochemistry, and Behavior February 1, 1979 Mark A. Geyer, Gary J. Rose, Lyle R. Petersen 7 citations
To test the possible involvement of serotonin-containing cells of the midbrain in mediating the effects of mescaline on startle responding, electrolytic lesions were made in either the dorsal or median raphe nucleus in rats. Decreases in either striatal or hippocampal tryptophan hydroxylase activity confirmed the effectiveness of the lesions. One week later, startle was measured in response to...
Psychopharmacology 1979 Claudio Castellano 8 citations
The effects of mescaline and amphetamine were investigated in BALB/cJ (BALB) and C57BL/6J (C57) mice using the five-choice Yerkes--Thompson Bryant--Bovet-Nitti apparatus for patterns discrimination. Two sets of experiments were carried out. In the first set, pretrial administration of mescaline (5, 10, and 20 mg/kg) was followed by performance improvements in the C57 mice, while performances of...
Journal of Psychedelic Drugs 1979 Alexander T. Shulgin 20 citations
(1979). Chemistry of Phenethylamines Related to Mescaline. Journal of Psychedelic Drugs: Vol. 11, Innovative Approached to Drug Abuse Treatment, pp. 41-52.
Journal of Pharmacology and Experimental Therapeutics December 1, 1978 Mark A. Geyer, Lyle R. Petersen, Gary J. Rose et al. 69 citations
Tactile startle responding by male Sprague-Dawley rats given 60 presentations of air-puff stimuli (37.5 psi) was measured after the intraperitoneal administration of graded doses of hallucinogens and other psychoactive drugs. Among the drugs tested were the indoleamine-derived compounds, lysergic acid diethylamide (LSD), N,N-dimethyltryptamine and psilocin, and the phenylethylamine-derived...
Journal of Pharmacy and Pharmacology September 1, 1978 Mitsutaka Nakamura, Hideaki Fukushima 25 citations
Journal Article Effect of 5, 6-dihydroxytryptamine on the head twitches induced by 5-HTP, 5-HT, mescaline and fludiazepam in mice Get access Mitsutaka Nakamura, Mitsutaka Nakamura Research and Development Centre, Pharmaceuticals Division, Sumitomo Chemical Co. Ltd., 4-2-1, Takatusukasa, Takarazuka, Hyogo, 665, Japan Correspondence: Research and Development Centre, Pharmaceuticals Division,...
Pharmacology, Biochemistry, and Behavior May 1, 1978 Robert J. Sbordone, Joseph A. Wingard, Mark L. Elliott et al. 12 citations
Several measures of aggressive behavior were investigated in three ages (40-50, 90-110, and 180-200 days old) and in three strains (Sprague-Dawley, Wistar, and Long-Evans) of rats before and following the administration of mescaline hydrochloride in a shock-elicited aggression situation. The measures included the number of fights, duration of fighting, latency of fighting, number of bites...
Science March 31, 1978 Jan G. Bruhn, J.‐e. Lindgren, Bo Holmstedt et al. 23 citations
Mescaline, anhalonine, lophophorine, pellotine, and anhalonidine have been identified in alkaloid extracts of a prehistoric specimen of Lophophora from a burial cave in west central Coahuila, Mexico. The specimen is associated with radiocarbon dates of A.D. 810 to 1070 and is one of the oldest materials ever submitted to alkaloid analysis.
European Journal of Pharmacology November 15, 1977 Om D. Gulati, Nandkumar S. Shah
The amine releasing action of mescaline was investigated in rat isolated hypothalamus labeled with 3H-metaraminol. Mescaline had no effect on the uptake of 3H-metaraminol but produced its release in a concentration-related manner. 4 x 10(-4) M mescaline, which produced submaximal effects was used for subsequent experiments. 3 x 10(-5) M cocaine had no effect on the 3H-metaraminol releasing...