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Chemischer Informationsdienst April 20, 1982 P. Iii Jacob, Alexander T. Shulgin
AbstractMonothioanaloga von Mescalin (I) und Isomescalin (II) werden dargestellt.
Journal of Natural Products March 1, 1982 Sunibhond Pummangura, Jerry L. Mclaughlin, R. C. Schifferdecker 10 citations
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCactus Alkaloids. LI. Lack of Mescaline Translocation in Grafted TrichocereusS. Pummangura, J. L. McLaughlin, and R. C. SchifferdeckerCite this: J. Nat. Prod. 1982, 45, 2, 224–225Publication Date (Print):March 1, 1982Publication History Published online1 July 2004Published inissue 1 March...
European Journal of Drug Metabolism and Pharmacokinetics 1982 C. Van Peteghem, A. Heyndrickx, W. Van Zele 3 citations
By means of a highly specific and sensitive mass fragmentographic method mescaline was measured in rabbit plasma samples, taken at various points after an i.v. injection. The pharmacokinetic behaviour conformed to the two-compartment open model. Half-life times of alpha and beta phases, velocity constants and steady-state distribution volumes of four subjects are reported.
Journal of Medicinal Chemistry November 1, 1981 Peyton Jacob, Alexander T. Shulgin 20 citations
Two monothio analogues of mescaline and three monothio analogues of 2,3,4-trimethoxyphenethylamine (isomescaline) have been synthesized and characterized. Only the two mescaline analogues (3-and 4-thiomescaline) were found to be psychotomimetics in man, being 6 and 12 times more potent than mescaline, respectively. All five compounds can serve as substrates for bovine plasma monoamine oxidase...
European Journal of Pharmacology November 1, 1981 Heidrun Fink, Wolfgang Oelssner 44 citations
Microinjections of LSD (0.05 microgram), mescaline (0.5 microgram) and serotonin (10 microgram) into the medial raphe nucleus of rats resulted in a strong potentiation of apomorphine (1 mg/kg i.p.)-induced hypermotility. The potentiating effect of LSD or serotonin was suppressed by simultaneous injections of methysergide (0.05 microgram) or cyproheptadine (0.05 microgram) into the medial raphe...
Teratology June 1, 1981 Kenneth S. Hirsch, Hans Fritz 19 citations
Abstract Mescaline was administered orally at doses of 16 and 32 mg/kg on the seventh through tenth days of gestation to pregnant cream‐strain hamsters. This treatment resulted in a dose‐dependent effect on reproductive success and skeletal ossification. The effect of mescaline on reproductive success included an increased number of resorptions resulting in a decreased litter size. The 32 mg/kg...
Science May 29, 1981 Bella T. Altura, Burton M. Altura 81 citations
Phencyclidine (PCP), lysergic acid diethylamide (LSD), and mescaline produced potent contractile responses on isolated basilar and middle cerebral arteries, where, in terms of potency, LSD > mescaline > PCP. All three drugs produced cerebrovasospasm in a concentration range which parallels that needed for their psychotomimetic and intoxicating actions. Specific receptors for PCP, which subserve...
Pharmacology, Biochemistry, and Behavior October 1, 1980 Randall L. Commissaris, K.E. Moore, Richard H. Rech 8 citations
Food-deprived male rats were trained to press a lever on a fixed ratio-40 (FR-40) operant schedule for food reinforcement. Administration of mescaline (4.0--10.0 mg/kg) immediately before the start of the operant session resulted in a cessation of responding for some portion of the 40-min period ("hallucinatory pause"). The duration of this pause was found to be dose-dependent. Although...
Psychopharmacology December 1, 1979 Robert J. Sbordone, Joseph A. Wingard, David A. Gorelick et al. 16 citations
Pairs of male Sprague-Dawley rats were administered mescaline, lysergic acid diethylamide (LSD), psilocin, N,N-dimethyltryptamine (DMT), 3,4-dimethoxyphenylethylamine (DMPEA), or 5-hydroxydopamine (5-OHDA) IP prior to being placed in a shock-elicited aggression situation. When foot shock was delivered, controls struck each other with their forepaws, but never engaged in either biting or...
Psychopharmacology September 1, 1979 Lothar Demisch, Manfred Neubauer 8 citations
Prolactin (PRL) and Growth Hormone (GH) secretions were studied in human serum after the oral administration of 5 mg/kg mescaline (3,4,5-trimethoxy-beta-phenylethylamine) or 2,3,4-trimethoxy-beta-phenylethylamine (2,3,4-TMPEA) respectively. Mescaline stimulated the secretion of PRL more than four-fold above base-line levels. Peak concentrations were found 90--120 min after drug intake. Five...