Behavioral effects of intracerebroventricular administration of LSD, DOM, mescaline or lisuride
Pharmacology Biochemistry and Behavior August 1, 1984 David J. Mokler, Richard H. Rech 17 citations
Lysergic acid diethylamide (LSD), 2,5-dimethoxy-4-methylamphetamine (DOM), mescaline, and the non-hallucinogenic LSD analogue lisuride were administered directly into the brain's lateral ventricle (intracerebroventricular, ICV) or injected into the abdomen (intraperitoneal, IP) of rats, and their effects on a fixed-ratio 40 operant behavior were compared. ICV administration of LSD, DOM, and mescaline disrupted behavior more potently than IP administration, with mescaline showing a 30-fold greater potency via ICV (ED50 74 micrograms) than IP (ED50 2251 micrograms). Lisuride showed no difference in potency between routes (ED50 4 micrograms both), suggesting its non-hallucinogenic effects are mediated differently.