Pharmacology, Biochemistry, and Behavior
November 1987
David J. Mokler, K W Stoudt, L C Sherman et al.
2,5-Dimethoxy-4-methylamphetamine (DOM) was infused into discrete brain regions of rats trained to press a bar for food reinforcement on a fixed ratio-40 (FR-40). Sites were chosen as major areas of the brain 5-hydroxytryptamine (5-HT) system: the dorsal and median raphe nuclei, dorsal hippocampus, lateral habenular nuclei and the prefrontal cortex. Following training in a fixed ratio-40...
Pharmacology, Biochemistry, and Behavior
May 1985
David J. Mokler, K W Stoudt, Richard H. Rech
Indolealkylamine and phenethylamine hallucinogens disrupted responding maintained under a fixed-ratio 40 (FR-40) schedule of reinforcement. LSD, DMT, mescaline and DOM produced dose-dependent decreases in number of reinforcers and increases in 10-sec periods of non-responding (pause-intervals). The 5HT agonist quipazine, as well as the LSD congener lisuride, altered response patterns in a...
Pharmacology, Biochemistry, and Behavior
September 1984
David J. Mokler, Randall L. Commissaris, J W Henck et al.
Administration of the indolealkylamine hallucinogen d-lysergic acid diethylamide (LSD), the phenethylamine hallucinogen 2,5-dimethoxy-4-methylamphetamine (DOM) and the putative 5-hydroxytryptamine (5-HT) agonist quipazine all produced a dose-dependent decrease in fixed ratio (FR-40) response rates and a concomitant increase in the number of 10-second pause intervals. Although naloxone (4.0...
Pharmacology, Biochemistry, and Behavior
August 1, 1984
David J. Mokler, Richard H. Rech
17 citations
The effects on a fixed ratio-40 (FR-40) operant behavior of intracerebroventricular (ICV) administration of the hallucinogens lysergic acid diethylamide (LSD), 2,5-dimethoxy-4-methylamphetamine (DOM), mescaline or the non-hallucinogenic LSD-analogue lisuride were compared with intraperitoneal (IP) administration. Infusion of LSD (8.5 to 34 micrograms) into the left lateral ventricle produced a...
Psychopharmacology
March 1, 1982
Randall L. Commissaris, Richard H. Rech
The effects of diazepam quipazine, lysergic acid diethylamide (LSD), and 2,5-dimethoxy-4-methylamphetamine (DOM) were examined on a conditioned suppression paradigm. Food-deprived rats were trained to drink a liquid diet from a tube. Subsequently, intermittent 7-s tones were presented during the daily 10-min sessions, the tube being electrified during the last 5 s of each tone. The subject...
Neuroscience & Biobehavioral Reviews
1982
Richard H. Rech, Randall L. Commissaris
Indole and phenethylamine-type hallucinogenic drugs were studied in an FR-40 operant behavioral procedure programmed to quantify "pausing,"-a behavioral disruption somewhat specific to hallucinatory drug effects. LSD, DOM, DMT and mescaline showed a potency ratio to produce pausing that is well correlated with the hallucinatory potencies of these agents in man. Furthermore, combinations of the...
Pharmacology, Biochemistry, and Behavior
October 1981
Randall L. Commissaris, Richard H. Rech
The present study examined the disruptive effects of the phenethylamine hallucinogen 2,5-dimethoxy-4-methylamphetamine (DOM) and the putative 5-hydroxytryptamine (5-HT) agonist quipazine on fixed ratio-40 (FR-40) operant responding alone or after pretreatment with putative 5-HT antagonist metergoline. Food-deprived male rats were trained to bar press on a FR-40 schedule for food reinforcements;...
Pharmacology, Biochemistry, and Behavior
June 1981
Randall L. Commissaris, David J. Mokler, William H. Lyness et al.
The hypothesis that 5-hydroxytryptamine (5-HT) neurons and/or receptors are involved in the mechanism of action of hallucinogens is supported by the fact that intraventricular administration of the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) selectively destroys central 5-HT neurons in the brain and potentiates the behavioral effects of lysergic acid diethylamide (LSD),...
Pharmacology, Biochemistry, and Behavior
May 1, 1981
Randall L. Commissaris, William H. Lyness, Richard H. Rech
29 citations
The purpose of the present study was to determine the role of central 5-hydroxytryptamine (5-HT) neuronal systems in the effects of d-lysergic acid diethylamide (LSD), 2,5-methoxy-4-methylamphetamine (DOM), pentobarbital (PB) and methaqualone (MQ) on punished responding in rats. Water-deprived rats were trained to drink from a tube that was electrified at intervals (variable interval 21 sec;...
Pharmacology, Biochemistry, and Behavior
May 1981
Randall L. Commissaris, William H. Lyness, K E Moore et al.
The present study was designed to examine the role of 5-hydroxytryptamine (5-HT) neurons in the behavioral effects of d-lysergic acid diethylamide (LSD), an indolealkylamine hallucinogen, 2.5-dimethoxy-4-methylamphetamine (DOM) and mescaline, phenethylamine hallucinogens, and phenobarbital, a non-hallucinogen. Male rats, maintained at 70-80% of their free-feeding weights, were trained to press...
Pharmacology, Biochemistry, and Behavior
November 1980
Randall L. Commissaris, William H. Lyness, J J Cordon et al.
The purpose of the present study was to determine the role of central catecholaminergic neuronal systems in the effects of LSD, DOM and d-amphetamine on fixed ratio (FR) operant responding in rats. Food-deprived male rats were trained to press a bar for food reinforcement on a FR-40 schedule. Control responding on this schedule is characterized by a rapid, constant rate of responding...
Pharmacology, Biochemistry, and Behavior
October 1, 1980
Randall L. Commissaris, K.E. Moore, Richard H. Rech
8 citations
Food-deprived male rats were trained to press a lever on a fixed ratio-40 (FR-40) operant schedule for food reinforcement. Administration of mescaline (4.0--10.0 mg/kg) immediately before the start of the operant session resulted in a cessation of responding for some portion of the 40-min period ("hallucinatory pause"). The duration of this pause was found to be dose-dependent. Although...
Pharmacology, Biochemistry, and Behavior
October 1980
Randall L. Commissaris, William H. Lyness, K E Moore et al.
Seven food deprived male rats were trained to press a bar on a fixed ratio-40 (FR-40) schedule of food reinforcement. Administration of 0.5 mg/kg 2,5-dimethoxy-4-methyl amphetamine (DOM) immediately before the start of the session resulted in cessation of responding for some portion of the 40-min test session. Three successive days of p-chlorophenylalanine (PCPA) administration (100 mg/kg) 30...