Effect of clozapine and molindone on plasma and brain levels of mescaline in mice.
N S Shah, O D Gulati
European Journal of Drug Metabolism and Pharmacokinetics October 1, 1984 DOI: 10.1007/bf03189681 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental animal study Peer reviewed |
|---|---|
| Population | Albino Swiss-Webster mice |
| Interventions | Mescaline Clozapine Molindone |
| Dose | clozapine 7.5, 15.0, and 30 mg/kg; molindone 4.0, 8.0, 16.0, and 48.0 mg/kg |
| Duration | Mescaline levels measured at 1, 2, and 3 h |
| Topics | Mescaline |
| Keywords | Brain Animals Mice Indoles Molindone Dibenzazepines Clozapine Time factors Female |
| Key findings | Clozapine pretreatment significantly increased plasma and brain levels of unchanged mescaline in mice at multiple time points and doses, while molindone increased mescaline levels only at the higher doses of 16.0 and 48.0 mg/kg. The authors state this indicates an adverse metabolic interaction between mescaline and drugs commonly used to treat mescaline-induced psychosis. |
Abstract
Levels of unchanged mescaline were examined in the plasma and brain of albino Swiss-Webster mice pretreated with various doses of either clozapine or molindone. In clozapine treated mice, the mescaline levels were statistically significantly higher at 2 and 3 h with 7.5 and 15.0 mg/kg and at 1, 2 and 3 h with 30 mg/kg. Molindone at 4.0 and 8.0 mg/kg produced no significant effect; at 16.0 and 48.0 mg/kg, the levels were significantly higher at 1 and 2 h. Elevated brain levels of mescaline by clozapine and molindone indicate an adverse metabolic interaction between a hallucinogen and drugs that are commonly used to treat mescaline-induced psychosis.
Comparable studies
Other preclinical and animal studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Brain mechanisms of hallucinogens and entactogens Humans and rats | 2001 | Review | |
| Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Zebrafish (Danio rerio) | 2012 | Experimental study | |
| Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Rats | 1976 | Experimental study | |
| Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups Rats (trained to discriminate saline from LSD tartrate) and rat cortical and... | 1996 | In vivo drug discrimination assay and in vitro radioligand binding assay |