The Japanese Journal of Pharmacology
October 1994
K Kitaichi, K Yamada, T Hasegawa et al.
In this study, we investigated whether risperidone, a serotonin-S2A (5-HT2A)/dopamine-D2 (D2)-receptor antagonist, inhibits phencyclidine (PCP)-induced stereotyped behaviors in comparison with haloperidol and ritanserin. Moreover, we also attempted to investigate the effects of these antipsychotics on the contents of dopamine, serotonin (5-HT) and their metabolites in rat striatum and frontal...
The Japanese Journal of Pharmacology
1992
Tsuneyuki Yamamoto, Masuo Ohno, Shin‐ichi Yatsugi et al.
7 citations
The effects of various nootropic candidates on mescaline-induced head-twitches were studied in mice. The number of head-twitches induced by mescaline (100 mg/kg, s.c.) was significantly reduced by idebenone (32 and 100 mg/kg, i.p.), minaprine (0.32-10 mg/kg, p.o.) and nebracetam (100 mg/kg, p.o.). Cholinesterase inhibitors such as tetrahydroaminoacridine (1 and 10 mg/kg, p.o.), NIK-247 (10 and...
The Japanese Journal of Pharmacology
1992
Tsuneyuki Yamamoto, Masuo Ohno, Shin‐ichi Yatsugi et al.
1 citation
The effects of various nootropic candidates on mescaline-induced head-twitches were studied in mice. The number of head-twitches induced by mescaline (100 mg/kg, s.c.) was significantly reduced by idebenone (32 and 100 mg/kg, i.p.), minaprine (0.32–10 mg/kg, p.o.) and nebracetam (100 mg/kg, p.o.). Cholinesterase inhibitors such as tetrahydroaminoacridine (1 and 10 mg/kg, p.o.), NIK-247 (10 and...
The Japanese Journal of Pharmacology
April 1, 1987
S Yoshida, T Kuga
Two kinds of electrical stimulation, low frequency stimulation (5 Hz, 1 msec, 5 pulses, every 20 sec) and high frequency stimulation (30 Hz, 0.1 msec, 20 pulses, every 20 sec), produced contractions in isolated guinea-pig vas deferens. These responses were blocked by alpha, beta-methylene-ATP, but not prazosin. Phentolamine potentiated the contractions produced by low frequency stimulation,...
The Japanese Journal of Pharmacology
1983
Tsuneyuki Yamamoto, Naoe Tazoe, Showa Ueki et al.
9 citations
The effect of zotepine, a new neuroleptic, on head-twitch induced by L-5-hydroxytryptophan (L-5HTP), mescaline and 2,5-dimethoxy-4-methylamphetamine (DOM) in mice and rats was compared with that of known neuroleptics and the serotonin receptor blocker cyproheptadine. Among the neuroleptics tested, zotepine and haloperidol produced potent inhibitory effects on head-twitch induced by these three...
The Japanese Journal of Pharmacology
1983
Tsuneyuki Yamamoto, Naoe Tazoe, Showa Ueki et al.
2 citations
The effect of zotepine, a new neuroleptic, on head-twitch induced by L-5-hydroxytryptophan (L-5HTP), mescaline and 2,5-dimethoxy-4-methylamphetamine (DOM) in mice and rats was compared with that of known neuroleptics and the serotonin receptor blocker cyproheptadine. Among the neuroleptics tested, zotepine and halo-peridol produced potent inhibitory effects on head-twitch induced by these three...
The Japanese Journal of Pharmacology
1971
B.d. Gupta, P.c. Dandiya, Mahima Gupta
78 citations
The Open Field Test situation is reported to produce autonomic nervous system reactivity determined emotional freezing and defecation (1, 2), cortical excitation determined rearing activity (3), and corpus striatum activity determined stereotyped ambulation (4, 5). Thus autonomic depressant drugs reduce emotional freezing (6), cortical excitant drugs augment rearing (7, 8), and hallucinatory...
The Japanese Journal of Pharmacology
1958
Hiroshi Takagi, Shigeru Yamamoto, Shuji Takaori et al.
11 citations
In 1943 in Switzerland, A. Hofmann (1) working on the synthesis of lysergic acid diethylamide (LSD-25), a common fragment of ergot alkaloids, noticed the peculiar sensation of vertigo and restlessness. Thenceforce it was reported by Stoll et al. (1, 2), Forrer et al. (3) and Rinkel et al. (4) that a small dose of LSD caused predominantly schizophrenic symptoms that were manifested in...