THE PRESERVATION OF SUBSTANCE P BY LYSERGIC ACID DIETHYLAMIDE
British Journal of Pharmacology and Chemotherapy September 1, 1957 DOI: 10.1111/j.1476-5381.1957.tb00149.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Guinea pig ileum and brain extract |
| Intervention | Lysergic acid diethylamide (LSD) |
| Topics | LSD Mescaline Psilocybin |
| Keywords | Strychnine Histamine Pharmacology Substance p Guinea pig Chlorpromazine Hallucinogen Morphine |
| Citations | 23 |
| Key findings | LSD potentiates the response to substance P and inhibits its destruction by brain extract, an effect antagonized by 2-bromo-LSD. |
Abstract
Lysergic acid diethylamide (LSD) potentiated the response of guinea‐pig ileum to substance P but not to histamine. It also inhibited the disappearance of substance P when incubated with guinea‐pig brain extract but not when incubated with chymotrypsin. Eserine, morphine, mescaline, chlorpromazine, ergometrine, strychnine and 2 bromo‐LSD did not have this effect. Oxytocin was not destroyed by brain extract. The inhibition of the destruction of substance P by LSD could be antagonized by 2 bromo‐LSD. This effect of LSD may have some relation to its pharmacological actions.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |