Psychopharmacological Studies of Lysergic Acid Diethylamide (LSD-25) Intoxication
A M A Archives of Neurology & Psychiatry December 1, 1957 DOI: 10.1001/archneurpsyc.1957.02330420113020 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | LSD |
| Keywords | Hallucinogen Pharmacology |
| Citations | 19 |
| Key findings | Conflicting reports on agents blocking LSD-25 effects arise from a failure to distinguish pharmacological antagonism from suppression. |
Abstract
One consequence of the recent interest in psychotomimetic drugs has been a search for pharmacological agents that will "block" drug-induced psychological disturbances and hallucinations. Fabing1reported that azacyclonol (Frenquel) in small doses prevented the occurrence of lysergic acid diethylamide (LSD-25) "psychoses" in man, although one of us (L. D. C.) was unable to verify this observation.2Other investigators have reported that LSD-25 intoxication is ameliorated by premedication with chlorpromazine,3,4serotonin,5and reserpine.4However, it has also been reported that serotonin6and reserpine3intensify LSD-25 effects. Hoch7found that premedication with amobarbital (Amytal) sodium and chlorpromazine did not prevent LSD-25 or mescaline intoxication but pointed out that such drugs produced suppressive effects when given at the height of the intoxication. Several reasons exist for this confusing state of affairs. There has been a failure to distinguish between true pharmacological antagonism (blocking) and suppression.
Comparable studies
Other narrative reviews on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Study of a New Schizophrenomimetic Drug—Sernyl | 1959 | Review | |
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| The Pharmacology of Lysergic Acid Diethylamide: A Review | 2008 | Review | |
| Serotonin research: contributions to understanding psychoses | 2008 | Review | |
| ADVERSE REACTIONS TO PSYCHEDELIC DRUGS. A REVIEW OF THE LITERATURE | 1984 | Review |
Citations in the library
Cited by 8
- The Pharmacology of Lysergic Acid Diethylamide: A Review CNS Neuroscience & Therapeutics November 11, 2008
- Chronic pain and psychedelics: a review and proposed mechanism of action Regional Anesthesia & Pain Medicine May 4, 2020
- The non-hallucinogen 2-bromo-lysergic acid diethylamide as preventative treatment for cluster headache: An open, non-randomized case series Cephalalgia March 26, 2010
- Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments Proceedings of the National Academy of Sciences November 27, 2023
- Serotonergic Psychedelics: Experimental Approaches for Assessing Mechanisms of Action Handbook of experimental pharmacology 2018
and 3 more in the library