A saline pond in a region in Antarctia where other lakes and ponds are frozen remains unfrozen at the prevailing low temperatures. The ecology of the pond is unique. A distinctive aerobic microbial population, though restricted to this natural habitat, adapts to growth in artificial culture. The growth habit of these organisms, as seen in nature and in laboratory culture, indicates a possible...
TWO DECADES AGO Hofmann ' accidentally discovered the hallucinogenic activity of d-lysergic acid diethylamide (LSD-25). Its ability to induce a model psychosis makes it an excellent laboratory device for the study of psychotic-like phenomena. LSD-25 has also been employed as an adjunct to psychotherapy because recall of repressed memories is enhanced and ego defensiveness to conflict laden...
The effect of 5-methoxy-N:N-dimethyltryptamine on the conditioned avoidance response of trained rats was compared quantitatively, using a shuttle-box, with that of several substituted tryptamines and LSD-25. 5-Methoxy-N:N-dimethyltryptamine, at a dose level of 19 µm/kg, had a pronounced effect on the conditioned avoidance response, much more pronounced than that due to the known psychotomimetic...
In a previous report7the administration of phencyclidine hydrochloride, a chemical compound with anesthetic and sedative properties, was shown to produce profound disturbances in reaction time, motor learning, and weight discrimination. These findings were obtained with normal subjects who had been given subanesthetic doses of the drug. The degree and pattern of drug-produced deficits closely...
Introduction Clinical and observational studies of the effects of lysergic acid diethylamide (LSD25) have aroused much interest in recent years because of the unusual nature of the alterations in functioning that have been observed. Many have seen a possible relationship between these alterations and the disturbances seen in schizophrenic syndromes or, more generally, under conditions of...
In the March 1961 issue of Psychologia Dr. Wilson Van Dusen presented LSD as a new means of arriving at satori, the Zen experience of sudden enlightenment. He said that the use of LSD is a faster method than years of meditation and suggested that the drug "could perhaps be used in a monastery in conjunction with conventional Zen practices to facilitate the student's development. ... " (1). From...
In a Swiss laboratory in 1943 an accidental discovery was made by a Swiss chemist.Dr. Hofmann, which was to bring a new approach to psychotherapy.This treatment which the author calls analytical and integrative therapy is based essentially on the trigger effects of the substance discovered which was named d-Iysergic acid diethylamide, or in short LSD-25.It is very difficult to describe the...
Schizophrenic patients given LSD-25 show an increase of psychopathological phenomena and a regression to the prime stage of their psychosis, the manifestations of which seem to be more directly related to the life history of the patients. ∗ It has also been observed that some “normal” experimental subjects show various paranoid symptoms with the same drug, but whether these are in any way...
LSD-25 in doses of 130 to 1300 µg/kg induced a small and significant rise in levels of rat brain serotonin within 10 to 120 minutes following administration. A single dose was as effective as several daily doses. In reserpine treated animals, LSD-25 induced a 2-fold elevation in brain serotonin, and effects were found 96 hours following a single dose of LSD-25. A dose-effect interaction of...