The effect of 5-methoxy-N:N-dimethyltryptamine on the conditioned avoidance response of trained rats was compared quantitatively, using a shuttle-box, with that of several substituted tryptamines and LSD-25. 5-Methoxy-N:N-dimethyltryptamine, at a dose level of 19 µm/kg, had a pronounced effect on the conditioned avoidance response, much more pronounced than that due to the known psychotomimetic...
The close intra-arterial injection of mescaline in adequate doses causes partial or complete paralysis in the dog neuromuscular preparation. Mescaline and curare tend to supplement one another with respect to their depressant actions on indirectly stimulated skeletal muscle. After complete blockade with mescaline, the muscle can readily be activated by direct stimulation. Following chronic...
Rats were injected intramuscularly with 5-HT or LSD and intravenously with 5-HT, LSD, BOL or equimolar concentrations of 5-HT + LSD or 5-HT + BOL. Appropriate saline controls were included. They were then exposed to a standard amount of Noble-Collip trauma. Animals receiving 5-HT i.m. showed a significant multiphasic mortality curve after trauma depending on dose of drug. With small doses,...
The influence of LSD-25 (i.v.) upon the optically evoked cortical potentials was studied in chronically prepared unanesthetized and noncurarized rabbits over a 23-hour period. With moderate doses of the drug (35 µg/animal) the potentials were enhanced for a period of over 6 hours. The time course of the amplitudes indicates a triphasic pattern. LSD-25 reduced the latency of the potentials by...