This is a review of an important but controversial subject, written by one of the important figures involved in the controversy. It was not possible to get a review in depth by someone who was not also involved in the controversy. With this in mind, this review was accepted for publication because it was written by an authority actively engaged in the problem and because it was thought...
In the course of studying the clinical effects of LSD-25 various workers have commented upon its possible use as an aid to psychiatric diagnosis. Stoll (1947) and Becker (1949) considered it to be of limited value in this respect. Condrau (1949) pointed out that it tended to exaggerate catatonic and hebephrenic features in schizophrenics and to produce a caricature of the personality in normal...
Journal Article Effect of the Administration of Lysergic Acid Diethylamide (LSD) on the Colloid Vesicles of the Pars Intermedia of the Toad Pituitary Get access FERMÍN C. ITURRIZA, FERMÍN C. ITURRIZA 1Cátedra de Embriología y Biología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata La Plata, Argentina Search for other works by this author on: Oxford Academic Google Scholar...
This study describes the short-term effects of administering LSD to normals as measured by pre and one-week-post-LSD tests of anxiety, attitudes, and performance. The hypothesis tested was that LSD would produce a rapid lowering of defenses resulting in (1) lower anxiety, (2) attitudinal changes, particularly in the form of decreased dogmatism and projection of aggression, and (3) increases in...
Two micrograms per kilogram of LSD‐25 was administered intravenously to five normal human subjects. The concentration of drug in plasma was determined serially over the subsequent 8 hours. LSD‐25 was found to be present in human plasma in relatively large quantities during the period of peak effect. The half‐life of LSD‐25 in human plasma was calculated to be 175 minutes.
A. Hofmann first noted that extraordinary psychic symptoms were induced by LSD-25 (D-lysergic acid diethylamide). Subsequently, W. A. Stoll25and G. Condrau5discussed these symptoms from a phenomenological point of view. Since then numerous studies have been made including those by J. Delay,7M. Rinkel,21W. Frederking,8,9S. Salvatore,22and H. Isbell and associates.12In spite of these...
Since 1959, 68 alcoholics have been treated with LSD. Twenty-six patients reported sobriety in the follow-up period. The nature of the experience appeared to bear an independent relationship to abstinence.
*Associate Attending, Division of Anesthesiology, Cook County Hospital and Hektoen Institute for Medical Research; Assistant Professor of Medicine and Psychiatry, Chicago Medical School, Chicago, Illinois. †Chairman, Division of Anesthesiology, Cook County Hospital and Hektoen Institute for Medical Research; Associate Professor of Surgery (Anesthesiology), Northwestern University, School of...
There has been, thus far, virtually no exploration of anempiricalbasis of the patterning of subjective reactions to lysergic acid diethylamide (LSD-25). Previous studies have been limited to general descriptions of the drug's effects, and the rare attempts to group the various specific effects have been based on a priori clinical concepts1(reviewed elsewhere). Furthermore, the relationships...
Preliminary results of a study of psychedelic therapy are reported. Patients receive LSD and mescaline in a supportive setting following intensive preparation. Subjective questionnaire data from 113 patients reveal a high frequency of claimed benefit, low frequency of negative reaction, and a high relation between claimed benefit and reported “greater awareness of ultimate reality” through the...