Complications Associated with Lysergic Acid Diethylamide (LSD-25)
JAMA July 14, 1962 DOI: 10.1001/jama.1962.03050280091013b (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Survey and literature review Peer reviewed |
|---|---|
| Intervention | LSD-25 |
| Topics | LSD |
| Keywords | Pharmacology |
| Citations | 65 |
| Key findings | A 1960 survey and literature search found very few toxic or psychological complications from LSD-25 use. |
Abstract
TWO DECADES AGO Hofmann ' accidentally discovered the hallucinogenic activity of d-lysergic acid diethylamide (LSD-25). Its ability to induce a model psychosis makes it an excellent laboratory device for the study of psychotic-like phenomena. LSD-25 has also been employed as an adjunct to psychotherapy because recall of repressed memories is enhanced and ego defensiveness to conflict laden material is reduced. Interest in this indole increased when it was found to be a serotonin antagonist that altered cerebral synaptic transmission. Almost 1,000 articles have reported on every aspect of its chemical, biological, and psychological activity. A substance capable of evoking such profound psychic symptoms as delusions, hallucinations, depersonalization, and euphoria or depression could be expected to have serious side effects. For this reason a survey of investigations using LSD-25 was carried out in 1960. The results of this inquiry and of a literature search revealed very few toxic or psychologic complications.
Comparable studies
Other cross-sectional and survey studies on LSD, most cited first.
Citations in the library
Cited by 31
- Human hallucinogen research: guidelines for safety. Journal of Psychopharmacology July 1, 2008
- The paradoxical psychological effects of lysergic acid diethylamide (LSD) Psychological Medicine February 5, 2016
- Ayahuasca, dimethyltryptamine, and psychosis: a systematic review of human studies Therapeutic Advances in Psychopharmacology February 23, 2017
- The current state of research on ayahuasca: A systematic review of human studies assessing psychiatric symptoms, neuropsychological functioning, and neuroimaging Journal of Psychopharmacology June 11, 2016
- User perceptions of the benefits and harms of hallucinogenic drug use: A web-based questionnaire study Journal of Substance Use July 30, 2010
and 26 more in the library