Bufotenine (5-hydroxy-N,N-dimethyltryptamine) has been reported to be behaviorally inactive or only very weakly active in man and animals; this may be a consequence of its low partition coefficient and resultant inability to penetrate the blood--brain barrier. The acetyl, propionyl, butyryl, isobutyryl, and pivalyl esters of bufotenine were prepared for future pharmacological evaluation....
The effect of 5-methoxy-N:N-dimethyltryptamine on the conditioned avoidance response of trained rats was compared quantitatively, using a shuttle-box, with that of several substituted tryptamines and LSD-25. 5-Methoxy-N:N-dimethyltryptamine, at a dose level of 19 µm/kg, had a pronounced effect on the conditioned avoidance response, much more pronounced than that due to the known psychotomimetic...