Lysergic acid diethylamide (LSD-25) produces a wide range of alterations in psychological functioning, including disturbances in ego functions, drive manifestations, and other psychopathology. These changes affect autonomic functioning, motor functioning, mood, conation, cognition, and sensorium, as well as thought, speech, affect, perception, and behavior. The alterations have been compared to disturbances seen in schizophrenic syndromes and conditions of altered consciousness such as sleep deprivation, hypnosis, and sensory isolation, sparking detailed exploration of the drug's effects.
Subjective reactions to LSD-25 can be grouped into distinct dimensions based on empirical data, rather than relying solely on clinical concepts. Previous research offered only general descriptions or a priori groupings, and neglected how personality relates to specific reactions. This report presents empirical evidence differentiating major dimensions of the LSD-25 reaction, addressing these gaps by analyzing clusters of reactions, building on earlier work by Salvatore and Hyde and the authors' own prior study.