Comparison of phencyclidine hydrochloride (Sernyl) with other drugs. Simulation of schizophrenic performance with phencyclidine hydrochloride (Sernyl), lysergic acid diethylamide (LSD-25), and amobarbital (Amytal) sodium; II. Symbolic and sequential thinking.
B. Cohen, G. Rosenbaum, E. Luby, J. Gottlieb
Archives of General Psychiatry May 1, 1962 DOI: 10.1001/archpsyc.1962.01710230063007 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Normal subjects and chronic schizophrenic patients |
| Interventions | Phencyclidine hydrochloride Lysergic acid diethylamide (LSD-25) Amobarbital sodium |
| Dose | subanesthetic doses |
| Topics | LSD |
| Citations | 131 |
| Key findings | Phencyclidine hydrochloride produced deficits in normal subjects that closely resembled those in chronic schizophrenic patients, suggesting a common underlying cause. |
Abstract
In a previous report7the administration of phencyclidine hydrochloride, a chemical compound with anesthetic and sedative properties, was shown to produce profound disturbances in reaction time, motor learning, and weight discrimination. These findings were obtained with normal subjects who had been given subanesthetic doses of the drug. The degree and pattern of drug-produced deficits closely approximated those found in a group of chronic schizophrenic patients given the same battery of tests without drugs. These psychotomimetic effects could not be attributed solely to the drug's hallucinogenic or to its sedative properties, since other drugs with each of these properties (lysergic acid diethylamide [LSD-25] and amobarbital sodium) produced neither the degree nor the pattern of deficits demonstrated under phencyclidine hydrochloride. It was tentatively concluded that the deficits seen in normal subjects under phencyclidine hydrochloride and in chronic schizophrenia might be attributable to a common underlying
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 18
- Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans Archives of General Psychiatry March 1, 1994
- Recent advances in the phencyclidine model of schizophrenia American Journal of Psychiatry October 1, 1991
- Psychedelic Effects of Ketamine in Healthy Volunteers Anesthesiology 1998
- NMDA receptor regulation of memory and behavior in humans Hippocampus October 1, 2001
- Clinical pharmacology of phencyclidine toxicity American Journal of Psychiatry November 1, 1977
and 13 more in the library